| Reaction Details |
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 | Report a problem with these data |
| Target | Lanosterol synthase |
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| Ligand | BDBM50456342 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1755336 (CHEMBL4190096) |
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| IC50 | 230±n/a nM |
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| Citation |  Tani, O; Akutsu, Y; Ito, S; Suzuki, T; Tateishi, Y; Yamaguchi, T; Niimi, T; Namatame, I; Chiba, Y; Sakashita, H; Kubota, T; Yanagi, T; Mizukami, S; Hirayama, K; Furukawa, K; Yamasaki, K NMR Biochemical Assay for Oxidosqualene Cyclase: Evaluation of Inhibitor Activities on Trypanosoma cruzi and Human Enzymes. J Med Chem61:5047-5053 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lanosterol synthase |
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| Name: | Lanosterol synthase |
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| Synonyms: | 2,3-epoxysqualene--lanosterol cyclase | LSS | LSS_HUMAN | OSC | Oxidosqualene--lanosterol cyclase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 83309.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_11231 |
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| Residue: | 732 |
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| Sequence: | MTEGTCLRRRGGPYKTEPATDLGRWRLNCERGRQTWTYLQDERAGREQTGLEAYALGLDT
KNYFKDLPKAHTAFEGALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLP
AGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGVGPDDPDLVRARNIL
HKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPM
SYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALL
NLYEHHHSAHLRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWYVDGPASTAFQE
HVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFAIQALLEAGGHHRPEFSSCLQKAHEFLRL
SQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEKCPHVTEHIPR
ERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQA
LKYFHKRFPEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMG
QTYRDGTACAEVSRACDFLLSRQMADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLM
AVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWALGRFS
QLYPERALAGHP
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| BDBM50456342 |
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| n/a |
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| Name | BDBM50456342 |
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| Synonyms: | CHEMBL4210513 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H30Cl3N3O2S |
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| Mol. Mass. | 494.906 |
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| SMILES | Cl.Cl.CN(C)Cc1ccc(cc1)N1CCC(CC1)N(C)S(=O)(=O)c1ccc(Cl)cc1 |
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| Structure | 
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