| Reaction Details |
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 | Report a problem with these data |
| Target | Acid ceramidase |
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| Ligand | BDBM319789 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1758531 (CHEMBL4193539) |
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| IC50 | 270±n/a nM |
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| Citation |  Li, Y; Chen, Q; Yang, L; Li, Y; Zhang, Y; Qiu, Y; Ren, J; Lu, C Identification of highly potent N-acylethanolamine acid amidase (NAAA) inhibitors: Optimization of the terminal phenyl moiety of oxazolidone derivatives. Eur J Med Chem139:214-221 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acid ceramidase |
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| Name: | Acid ceramidase |
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| Synonyms: | AC | ACDase | ASAH1_RAT | Acid CDase | Acid ceramidase | Acid ceramidase (AC) | Acylsphingosine deacylase | Asah1 | N-acylsphingosine amidohydrolase |
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| Type: | Enzyme |
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| Mol. Mass.: | 44450.22 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | Q6P7S1 |
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| Residue: | 394 |
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| Sequence: | MLGRSLLTWVLAAAVTCAQAQQVPPWTEDCRKSTYPPSGPTYRGPVPWYTINLDLPPYKR
WHELLAHKAPVLRTLVNSISNLVNAFVPSGKIMQMVDEKLPGLIGSIPGPFGEEMRGIAD
VTGIPLGEIISFNIFYELFTMCTSIITEDGKGHLLHGRNMDFGIFLGWNINNNTWVVTEE
LKPLTVNLDFQRNNKTVFKATSFAGYVGMLTGFKPGLLSLTLNERFSLNGGYLGILEWMF
GKKNAQWVGFITRSVLENSTSYEEAKNILTKTKITAPAYFILGGNQSGEGCVITRERKES
LDVYELDPKHGRWYVVQTNYDRWKNTLFLDDRRTPAKKCLNHTTQKNLSFATIYDVLSTK
PVLNKLTVFTTLIDVTKDQFESHLRDCPDPCIGW
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| BDBM319789 |
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| n/a |
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| Name | BDBM319789 |
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| Synonyms: | US10174015, Compound 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H19NO3 |
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| Mol. Mass. | 261.3163 |
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| SMILES | O=C(CCCCCc1ccccc1)N1CCOC1=O |
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| Structure | 
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