| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily A member 1 |
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| Ligand | BDBM50279106 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1758559 (CHEMBL4193567) |
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| IC50 | 250±n/a nM |
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| Citation |  Zidar, N; ?ula, A; Toma?i?, T; Rogers, M; Kirby, RW; Tytgat, J; Peigneur, S; Kikelj, D; Ila?, J; Ma?i?, LP Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels. Eur J Med Chem139:232-241 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium voltage-gated channel subfamily A member 1 |
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| Name: | Potassium voltage-gated channel subfamily A member 1 |
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| Synonyms: | KCNA1 | KCNA1_HUMAN | Potassium (voltage dependent) | Potassium voltage-gated channel subfamily A member 1 | Voltage-gated potassium channel | Voltage-gated potassium channel subfamily A member 1/beta-1 | Voltage-gated potassium channel subunit Kv1.1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 56451.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Potassium (voltage dependent) 0 0::Q09470 |
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| Residue: | 495 |
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| Sequence: | MTVMSGENVDEASAAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPN
TLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFY
ELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILIS
IVIFCLETLPELKDDKDFTGTVHRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRF
FACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVF
RIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIP
DAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETE
GEEQAQLLHVSSPNLASDSDLSRRSSSTMSKSEYMEIEEDMNNSIAHYRQVNIRTANCTT
ANQNCVNKSKLLTDV
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| BDBM50279106 |
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| n/a |
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| Name | BDBM50279106 |
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| Synonyms: | 4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one | 5-(4-phenoxybutoxy)psoralen | CHEMBL444449 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18O5 |
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| Mol. Mass. | 350.3646 |
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| SMILES | O=c1ccc2c(OCCCCOc3ccccc3)c3ccoc3cc2o1 |
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| Structure | 
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