| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine-specific demethylase 3A |
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| Ligand | BDBM293660 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1758843 (CHEMBL4193851) |
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| IC50 | >4000±n/a nM |
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| Citation |  Chen, YK; Bonaldi, T; Cuomo, A; Del Rosario, JR; Hosfield, DJ; Kanouni, T; Kao, SC; Lai, C; Lobo, NA; Matuszkiewicz, J; McGeehan, A; O'Connell, SM; Shi, L; Stafford, JA; Stansfield, RK; Veal, JM; Weiss, MS; Yuen, NY; Wallace, MB Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models. ACS Med Chem Lett8:869-874 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine-specific demethylase 3A |
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| Name: | Lysine-specific demethylase 3A |
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| Synonyms: | JHDM2A | JMJD1 | JMJD1A | JmjC domain-containing histone demethylation protein 2A | Jumonji domain-containing protein 1A | KDM3A | KDM3A_HUMAN | KIAA0742 | Lysine-specific demethylase 3A (KDM3A) | TSGA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 147368.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y4C1 |
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| Residue: | 1321 |
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| Sequence: | MVLTLGESWPVLVGRRFLSLSAADGSDGSHDSWDVERVAEWPWLSGTIRAVSHTDVTKKD
LKVCVEFDGESWRKRRWIEVYSLLRRAFLVEHNLVLAERKSPEISERIVQWPAITYKPLL
DKAGLGSITSVRFLGDQQRVFLSKDLLKPIQDVNSLRLSLTDNQIVSKEFQALIVKHLDE
SHLLKGDKNLVGSEVKIYSLDPSTQWFSATVINGNPASKTLQVNCEEIPALKIVDPSLIH
VEVVHDNLVTCGNSARIGAVKRKSSENNGTLVSKQAKSCSEASPSMCPVQSVPTTVFKEI
LLGCTAATPPSKDPRQQSTPQAANSPPNLGAKIPQGCHKQSLPEEISSCLNTKSEALRTK
PDVCKAGLLSKSSQIGTGDLKILTEPKGSCTQPKTNTDQENRLESVPQALTGLPKECLPT
KASSKAELEIANPPELQKHLEHAPSPSDVSNAPEVKAGVNSDSPNNCSGKKVEPSALACR
SQNLKESSVKVDNESCCSRSNNKIQNAPSRKSVLTDPAKLKKLQQSGEAFVQDDSCVNIV
AQLPKCRECRLDSLRKDKEQQKDSPVFCRFFHFRRLQFNKHGVLRVEGFLTPNKYDNEAI
GLWLPLTKNVVGIDLDTAKYILANIGDHFCQMVISEKEAMSTIEPHRQVAWKRAVKGVRE
MCDVCDTTIFNLHWVCPRCGFGVCVDCYRMKRKNCQQGAAYKTFSWLKCVKSQIHEPENL
MPTQIIPGKALYDVGDIVHSVRAKWGIKANCPCSNRQFKLFSKPASKEDLKQTSLAGEKP
TLGAVLQQNPSVLEPAAVGGEAASKPAGSMKPACPASTSPLNWLADLTSGNVNKENKEKQ
PTMPILKNEIKCLPPLPPLSKSSTVLHTFNSTILTPVSNNNSGFLRNLLNSSTGKTENGL
KNTPKILDDIFASLVQNKTTSDLSKRPQGLTIKPSILGFDTPHYWLCDNRLLCLQDPNNK
SNWNVFRECWKQGQPVMVSGVHHKLNSELWKPESFRKEFGEQEVDLVNCRTNEIITGATV
GDFWDGFEDVPNRLKNEKEPMVLKLKDWPPGEDFRDMMPSRFDDLMANIPLPEYTRRDGK
LNLASRLPNYFVRPDLGPKMYNAYGLITPEDRKYGTTNLHLDVSDAANVMVYVGIPKGQC
EQEEEVLKTIQDGDSDELTIKRFIEGKEKPGALWHIYAAKDTEKIREFLKKVSEEQGQEN
PADHDPIHDQSWYLDRSLRKRLHQEYGVQGWAIVQFLGDVVFIPAGAPHQVHNLYSCIKV
AEDFVSPEHVKHCFWLTQEFRYLSQTHTNHEDKLQVKNVIYHAVKDAVAMLKASESSFGK
P
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| BDBM293660 |
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| n/a |
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| Name | BDBM293660 |
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| Synonyms: | 3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahydronaphthalen-1- | US10106534, Example 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H25N3O2 |
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| Mol. Mass. | 387.4742 |
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| SMILES | CN(c1ccccc1)c1ccc2[C@H](CNc3cnccc3C(O)=O)CCCc2c1 |r| |
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| Structure | 
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