| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Lysine--tRNA ligase |
|---|
| Ligand | BDBM50434379 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1760358 (CHEMBL4195366) |
|---|
| IC50 | 120±n/a nM |
|---|
| Citation |  Das, P; Babbar, P; Malhotra, N; Sharma, M; Jachak, GR; Gonnade, RG; Shanmugam, D; Harlos, K; Yogavel, M; Sharma, A; Reddy, DS Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite. J Med Chem61:5664-5678 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Lysine--tRNA ligase |
|---|
| Name: | Lysine--tRNA ligase |
|---|
| Synonyms: | 6.1.1.6 | Lysine--tRNA ligase | Lysyl-tRNA synthetase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 67597.87 |
|---|
| Organism: | Plasmodium falciparum (isolate 3D7) |
|---|
| Description: | ChEMBL_108434 |
|---|
| Residue: | 583 |
|---|
| Sequence: | MTSKSFLLSFLKYKHVNTYIFEKSFSKILKNTKKHIDCHLKSCFVTMNEKKEHVLEGEKN
KRVVNASKDKKKEEEGEVDPRLYFENRSKFIQDQKDKGINPYPHKFERTISIPEFIEKYK
DLGNGEHLEDTILNITGRIMRVSASGQKLRFFDLVGDGEKIQVLANYSFHNHEKGNFAEC
YDKIRRGDIVGIVGFPGKSKKGELSIFPKETILLSACLHMLPMKYGLKDTEIRYRQRYLD
LLINESSRHTFVTRTKIINFLRNFLNERGFFEVETPMMNLIAGGANARPFITHHNDLDLD
LYLRIATELPLKMLIVGGIDKVYEIGKVFRNEGIDNTHNPEFTSCEFYWAYADYNDLIKW
SEDFFSQLVYHLFGTYKISYNKDGPENQPIEIDFTPPYPKVSIVEEIEKVTNTILEQPFD
SNETIEKMINIIKEHKIELPNPPTAAKLLDQLASHFIENKYNDKPFFIVEHPQIMSPLAK
YHRTKPGLTERLEMFICGKEVLNAYTELNDPFKQKECFKLQQKDREKGDTEAAQLDSAFC
TSLEYGLPPTGGLGLGIDRITMFLTNKNSIKDVILFPTMRPAN
|
|
|
|---|
| BDBM50434379 |
|---|
| n/a |
|---|
| Name | BDBM50434379 |
|---|
| Synonyms: | CLADOSPORIN |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H20O5 |
|---|
| Mol. Mass. | 292.327 |
|---|
| SMILES | C[C@H]1CCC[C@H](C[C@H]2Cc3cc(O)cc(O)c3C(=O)O2)O1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
