| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine--tRNA ligase |
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| Ligand | BDBM50457624 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1760358 (CHEMBL4195366) |
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| IC50 | 5800±n/a nM |
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| Citation |  Das, P; Babbar, P; Malhotra, N; Sharma, M; Jachak, GR; Gonnade, RG; Shanmugam, D; Harlos, K; Yogavel, M; Sharma, A; Reddy, DS Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite. J Med Chem61:5664-5678 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine--tRNA ligase |
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| Name: | Lysine--tRNA ligase |
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| Synonyms: | 6.1.1.6 | Lysine--tRNA ligase | Lysyl-tRNA synthetase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 67597.87 |
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| Organism: | Plasmodium falciparum (isolate 3D7) |
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| Description: | ChEMBL_108434 |
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| Residue: | 583 |
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| Sequence: | MTSKSFLLSFLKYKHVNTYIFEKSFSKILKNTKKHIDCHLKSCFVTMNEKKEHVLEGEKN
KRVVNASKDKKKEEEGEVDPRLYFENRSKFIQDQKDKGINPYPHKFERTISIPEFIEKYK
DLGNGEHLEDTILNITGRIMRVSASGQKLRFFDLVGDGEKIQVLANYSFHNHEKGNFAEC
YDKIRRGDIVGIVGFPGKSKKGELSIFPKETILLSACLHMLPMKYGLKDTEIRYRQRYLD
LLINESSRHTFVTRTKIINFLRNFLNERGFFEVETPMMNLIAGGANARPFITHHNDLDLD
LYLRIATELPLKMLIVGGIDKVYEIGKVFRNEGIDNTHNPEFTSCEFYWAYADYNDLIKW
SEDFFSQLVYHLFGTYKISYNKDGPENQPIEIDFTPPYPKVSIVEEIEKVTNTILEQPFD
SNETIEKMINIIKEHKIELPNPPTAAKLLDQLASHFIENKYNDKPFFIVEHPQIMSPLAK
YHRTKPGLTERLEMFICGKEVLNAYTELNDPFKQKECFKLQQKDREKGDTEAAQLDSAFC
TSLEYGLPPTGGLGLGIDRITMFLTNKNSIKDVILFPTMRPAN
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| BDBM50457624 |
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| n/a |
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| Name | BDBM50457624 |
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| Synonyms: | CHEMBL4215932 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H20O5 |
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| Mol. Mass. | 292.327 |
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| SMILES | [H][C@@]1(C[C@H]2Cc3cc(O)cc(O)c3C(=O)O2)CCC[C@H](C)O1 |r| |
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| Structure | 
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