Reaction Details |
| Report a problem with these data |
Target | Phosphatidylinositol 4-kinase beta |
---|
Ligand | BDBM50042924 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1760894 (CHEMBL4195902) |
---|
IC50 | 19±n/a nM |
---|
Citation | Reuberson, J; Horsley, H; Franklin, RJ; Ford, D; Neuss, J; Brookings, D; Huang, Q; Vanderhoydonck, B; Gao, LJ; Jang, MY; Herdewijn, P; Ghawalkar, A; Fallah-Arani, F; Khan, AR; Henshall, J; Jairaj, M; Malcolm, S; Ward, E; Shuttleworth, L; Lin, Y; Li, S; Louat, T; Waer, M; Herman, J; Payne, A; Ceska, T; Doyle, C; Pitt, W; Calmiano, M; Augustin, M; Steinbacher, S; Lammens, A; Allen, R Discovery of a Potent, Orally Bioavailable PI4KIII? Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo. J Med Chem61:6705-6723 (2018) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Phosphatidylinositol 4-kinase beta |
---|
Name: | Phosphatidylinositol 4-kinase beta |
Synonyms: | NPIK | PI4-kinase beta subunit | PI4K-beta | PI4K92 | PI4KB | PI4KB_HUMAN | PI4Kbeta | PIK4B | PIK4CB | Phosphatidylinositol 4-kinase beta | Phosphatidylinositol 4-kinase, PI4K | PtdIns 4-kinase beta |
Type: | Protein |
Mol. Mass.: | 91373.30 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 816 |
Sequence: | MGDTVVEPAPLKPTSEPTSGPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVK
LLHGGVAVSSRGTPLELVNGDGVDSEIRCLDDPPAQIREEEDEMGAAVASGTAKGARRRR
QNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLL
NMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLI
LSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVEN
EDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLN
HKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPE
NRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCD
NISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEK
VRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKI
LVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGY
CLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGG
LDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSM
TEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM
|
|
|
BDBM50042924 |
---|
n/a |
---|
Name | BDBM50042924 |
Synonyms: | CHEMBL1229535 |
Type | Small organic molecule |
Emp. Form. | C14H16ClN3O4S2 |
Mol. Mass. | 389.878 |
SMILES | CC(=O)\N=c1\[nH]c(C)c(s1)-c1ccc(Cl)c(c1)S(=O)(=O)NCCO |
Structure |
|