| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphatidylinositol 4-kinase beta |
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| Ligand | BDBM50457854 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1760893 (CHEMBL4195901) |
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| IC50 | 19±n/a nM |
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| Citation |  Reuberson, J; Horsley, H; Franklin, RJ; Ford, D; Neuss, J; Brookings, D; Huang, Q; Vanderhoydonck, B; Gao, LJ; Jang, MY; Herdewijn, P; Ghawalkar, A; Fallah-Arani, F; Khan, AR; Henshall, J; Jairaj, M; Malcolm, S; Ward, E; Shuttleworth, L; Lin, Y; Li, S; Louat, T; Waer, M; Herman, J; Payne, A; Ceska, T; Doyle, C; Pitt, W; Calmiano, M; Augustin, M; Steinbacher, S; Lammens, A; Allen, R Discovery of a Potent, Orally Bioavailable PI4KIII? Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo. J Med Chem61:6705-6723 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphatidylinositol 4-kinase beta |
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| Name: | Phosphatidylinositol 4-kinase beta |
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| Synonyms: | NPIK | PI4-kinase beta subunit | PI4K-beta | PI4K92 | PI4KB | PI4KB_HUMAN | PI4Kbeta | PIK4B | PIK4CB | Phosphatidylinositol 4-kinase beta | Phosphatidylinositol 4-kinase, PI4K | PtdIns 4-kinase beta |
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| Type: | Protein |
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| Mol. Mass.: | 91373.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 816 |
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| Sequence: | MGDTVVEPAPLKPTSEPTSGPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVK
LLHGGVAVSSRGTPLELVNGDGVDSEIRCLDDPPAQIREEEDEMGAAVASGTAKGARRRR
QNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLL
NMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLI
LSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVEN
EDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLN
HKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPE
NRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCD
NISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEK
VRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKI
LVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGY
CLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGG
LDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSM
TEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM
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| BDBM50457854 |
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| n/a |
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| Name | BDBM50457854 |
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| Synonyms: | CHEMBL4206816 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H22N8OS |
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| Mol. Mass. | 446.528 |
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| SMILES | Cc1ccc(NC(=O)N2CCN(CC2)c2nc(N)nc3sc(nc23)-c2cccnc2)cc1 |
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| Structure | 
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