Reaction Details |
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Target | Liver carboxylesterase 1 |
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Ligand | BDBM50458275 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1762692 (CHEMBL4197939) |
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Ki | 14±n/a nM |
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Citation | Binder, RJ; Hatfield, MJ; Chi, L; Potter, PM Facile synthesis of 1,2-dione-containing abietane analogues for the generation of human carboxylesterase inhibitors. Eur J Med Chem149:79-89 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Liver carboxylesterase 1 |
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Name: | Liver carboxylesterase 1 |
Synonyms: | Acyl coenzyme A:cholesterol acyltransferase | Acyl-CoA: cholesterol acyltransferase (ACAT) | CES1 | CES2 | EST1_HUMAN | SES1 | Serine hydrolase (CES1) |
Type: | Protein |
Mol. Mass.: | 62520.83 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 567 |
Sequence: | MWLRAFILATLSASAAWGHPSSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPL
GPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSELFTNRKENIPLKLSEDCLYLN
IYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFST
GDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLF
HRAISESGVALTSVLVKKGDVKPLAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLK
MKFLSLDLQGDPRESQPLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGINKQEFGWLIP
MQLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAKELIPEATEKYLGGTDDTVKKKDLFLDL
IADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPF
LKEGASEEEIRLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEGYLQIGANTQAAQKLK
DKEVAFWTNLFAKKAVEKPPQTEHIEL
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BDBM50458275 |
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n/a |
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Name | BDBM50458275 |
Synonyms: | CHEMBL4204853 |
Type | Small organic molecule |
Emp. Form. | C16H15FO2 |
Mol. Mass. | 258.2875 |
SMILES | CC1(C)CCc2ccc3C(F)=CC(=O)C(=O)c3c2C1 |c:10| |
Structure |
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