| Reaction Details |
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 | Report a problem with these data |
| Target | Ubiquitin carboxyl-terminal hydrolase 2 |
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| Ligand | BDBM50458417 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1763387 (CHEMBL4198634) |
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| IC50 | >100000±n/a nM |
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| Citation |  Tomala, MD; Magiera-Mularz, K; Kubica, K; Krzanik, S; Zieba, B; Musielak, B; Pustula, M; Popowicz, GM; Sattler, M; Dubin, G; Skalniak, L; Holak, TA Identification of small-molecule inhibitors of USP2a. Eur J Med Chem150:261-267 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ubiquitin carboxyl-terminal hydrolase 2 |
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| Name: | Ubiquitin carboxyl-terminal hydrolase 2 |
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| Synonyms: | 41 kDa ubiquitin-specific protease | Deubiquitinating enzyme 2 | UBP2_HUMAN | UBP41 | USP2 | Ubiquitin thioesterase 2 | Ubiquitin-specific-processing protease 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 68093.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_103660 |
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| Residue: | 605 |
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| Sequence: | MSQLSSTLKRYTESARYTDAHYAKSGYGAYTPSSYGANLAASLLEKEKLGFKPVPTSSFL
TRPRTYGPSSLLDYDRGRPLLRPDITGGGKRAESQTRGTERPLGSGLSGGSGFPYGVTNN
CLSYLPINAYDQGVTLTQKLDSQSDLARDFSSLRTSDSYRIDPRNLGRSPMLARTRKELC
TLQGLYQTASCPEYLVDYLENYGRKGSASQVPSQAPPSRVPEIISPTYRPIGRYTLWETG
KGQAPGPSRSSSPGRDGMNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLY
MRDLHHGSNAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQE
FLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLK
SSLTCTDCGYCSTVFDPFWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCR
GRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNHAV
YNLYAVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELAS
PPSRM
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| BDBM50458417 |
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| n/a |
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| Name | BDBM50458417 |
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| Synonyms: | CHEMBL4203489 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H17N3O4S |
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| Mol. Mass. | 395.432 |
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| SMILES | CCCn1nc(C(=O)OCc2cc(on2)-c2cccs2)c2ccccc2c1=O |
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| Structure | 
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