| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Penicillin-binding protein 1B |
|---|
| Ligand | BDBM50458510 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1763994 (CHEMBL4199241) |
|---|
| IC50 | 232000±n/a nM |
|---|
| Citation |  Yu, JY; Cheng, HJ; Wu, HR; Wu, WS; Lu, JW; Cheng, TJ; Wu, YT; Fang, JM Structure-based design of bacterial transglycosylase inhibitors incorporating biphenyl, amine linker and 2-alkoxy-3-phosphorylpropanoate moieties. Eur J Med Chem150:729-741 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Penicillin-binding protein 1B |
|---|
| Name: | Penicillin-binding protein 1B |
|---|
| Synonyms: | B9X91_01540 | CEJ63_06105 | EJB02_02435 | FE003_06205 | Murein polymerase | PBP-1b | PBP1b | Penicillin-binding protein 1B | SAMEA104305229_00571 | SAMEA104305325_03053 | SAMEA104305337_07354 | mrcB | mrcB_2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 88233.96 |
|---|
| Organism: | Acinetobacter baumannii |
|---|
| Description: | ChEMBL_117791 |
|---|
| Residue: | 798 |
|---|
| Sequence: | MKFERGIGFFALIFSILVIGAFIALSIYLIRLDNIIREKFEGQRWDIPAKVFARPLEIYN
NAPITQANFTQELKLLGYKTSSNYDKSGTYVAQGSNMYVHTRGFDYGDSVESEQVLELSF
ANDQVVEVRSTKPSSTGVARLEPLLIGGIYPQHNEDRVLIKLNSVPKPLIEALISTEDRN
FYHHHGISIRGTARALVSNVTGGRRQGGSTLTQQLVKNFYLTPERTLKRKVNEALMALLI
ELHYSKDEILEAYLNEVNLGQNGNYSINGYGLASQFYFGLPLRELNVAQQAYLVGLVQGP
SLYNPWKNPEGAKNRRDTVLNNMRVMGYLTQAEYETEIARPLNVLSKPSLGPAKFPDFLD
IVRRQLRTEYQESDLTNQGLRIFTTLDPIAQTQVQNAFKASVERLANSNPARLKNLQGAV
LIAHPENGELIAAVGSTQDFTGFNRALDAKRQVGSLLKPVIYLSAIESGRYNWASQIEDA
PISVPVDGGKSWTPKNYSGGGHGIVSLSEALANSYNLSAVRLGQEFGLSTFTNNLRKFGV
ESTIPAYPSIFLGAVNMSPMEVLGIYENFATGGFKYPTRAIRSVVDANGRLLDRYGLNVQ
QTIDPSVGYIMNYGLQQVMSSGTGRAAYNSLSPALKLAGKSGTTNDTRDSWFAGYSGNHV
AVVWLGLDDNKVTGLTGSSGALPVWINVMKQLRQTPVNLRQPDSVQWQWIDRASGDLSAQ
ACDGAMYIPMLAHTVPHRATPCGAPYYQVDPTYTPQSDNTIPEPQDDNTDSYIRESENQM
EQDLSNNTRIISSGSYNN
|
|
|
|---|
| BDBM50458510 |
|---|
| n/a |
|---|
| Name | BDBM50458510 |
|---|
| Synonyms: | CHEMBL4211590 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C36H55N4O6P |
|---|
| Mol. Mass. | 670.8189 |
|---|
| SMILES | CCCCCCCCCCCCn1cc(CO[C@H](CP(O)(=O)OCCCNCc2ccc(cc2)-c2ccccc2)C(=O)OCC)nn1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
