| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphatidylcholine:ceramide cholinephosphotransferase 2 |
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| Ligand | BDBM50458918 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1764945 (CHEMBL4200192) |
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| IC50 | 740±n/a nM |
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| Citation |  Mo, M; Yang, J; Jiang, XC; Cao, Y; Fei, J; Chen, Y; Qi, X; Chu, Y; Zhou, L; Ye, D Discovery of 4-Benzyloxybenzo[ d]isoxazole-3-amine Derivatives as Highly Selective and Orally Efficacious Human Sphingomyelin Synthase 2 Inhibitors that Reduce Chronic Inflammation in db/ db Mice. J Med Chem61:8241-8254 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphatidylcholine:ceramide cholinephosphotransferase 2 |
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| Name: | Phosphatidylcholine:ceramide cholinephosphotransferase 2 |
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| Synonyms: | SGMS2 | SMS2 | SMS2_HUMAN | Sphingomyelin synthase 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42294.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_108027 |
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| Residue: | 365 |
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| Sequence: | MDIIETAKLEEHLENQPSDPTNTYARPAEPVEEENKNGNGKPKSLSSGLRKGTKKYPDYI
QIAMPTESRNKFPLEWWKTGIAFIYAVFNLVLTTVMITVVHERVPPKELSPPLPDKFFDY
IDRVKWAFSVSEINGIILVGLWITQWLFLRYKSIVGRRFCFIIGTLYLYRCITMYVTTLP
VPGMHFQCAPKLNGDSQAKVQRILRLISGGGLSITGSHILCGDFLFSGHTVTLTLTYLFI
KEYSPRHFWWYHLICWLLSAAGIICILVAHEHYTIDVIIAYYITTRLFWWYHSMANEKNL
KVSSQTNFLSRAWWFPIFYFFEKNVQGSIPCCFSWPLSWPPGCFKSSCKKYSRVQKIGED
NEKST
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| BDBM50458918 |
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| n/a |
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| Name | BDBM50458918 |
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| Synonyms: | CHEMBL4210244 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H13F2N3O2 |
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| Mol. Mass. | 353.3222 |
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| SMILES | Fc1cccc(F)c1COc1cccc2onc(Nc3cccnc3)c12 |
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| Structure | 
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