| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphatidylcholine:ceramide cholinephosphotransferase 1 |
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| Ligand | BDBM50458942 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1764948 (CHEMBL4200195) |
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| IC50 | 79000±n/a nM |
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| Citation |  Mo, M; Yang, J; Jiang, XC; Cao, Y; Fei, J; Chen, Y; Qi, X; Chu, Y; Zhou, L; Ye, D Discovery of 4-Benzyloxybenzo[ d]isoxazole-3-amine Derivatives as Highly Selective and Orally Efficacious Human Sphingomyelin Synthase 2 Inhibitors that Reduce Chronic Inflammation in db/ db Mice. J Med Chem61:8241-8254 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphatidylcholine:ceramide cholinephosphotransferase 1 |
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| Name: | Phosphatidylcholine:ceramide cholinephosphotransferase 1 |
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| Synonyms: | MOB | Medulla oblongata-derived protein | Protein Mob | SGMS1 | SMS1 | SMS1_HUMAN | Sphingomyelin synthase 1 | TMEM23 | Transmembrane protein 23 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48630.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109868 |
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| Residue: | 413 |
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| Sequence: | MKEVVYWSPKKVADWLLENAMPEYCEPLEHFTGQDLINLTQEDFKKPPLCRVSSDNGQRL
LDMIETLKMEHHLEAHKNGHANGHLNIGVDIPTPDGSFSIKIKPNGMPNGYRKEMIKIPM
PELERSQYPMEWGKTFLAFLYALSCFVLTTVMISVVHERVPPKEVQPPLPDTFFDHFNRV
QWAFSICEINGMILVGLWLIQWLLLKYKSIISRRFFCIVGTLYLYRCITMYVTTLPVPGM
HFNCSPKLFGDWEAQLRRIMKLIAGGGLSITGSHNMCGDYLYSGHTVMLTLTYLFIKEYS
PRRLWWYHWICWLLSVVGIFCILLAHDHYTVDVVVAYYITTRLFWWYHTMANQQVLKEAS
QMNLLARVWWYRPFQYFEKNVQGIVPRSYHWPFPWPVVHLSRQVKYSRLVNDT
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| BDBM50458942 |
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| n/a |
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| Name | BDBM50458942 |
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| Synonyms: | CHEMBL4202973 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H14ClN3O2 |
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| Mol. Mass. | 351.786 |
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| SMILES | Clc1ccccc1COc1cccc2onc(Nc3cccnc3)c12 |
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| Structure | 
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