Reaction Details |
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Target | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic |
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Ligand | BDBM50459309 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1766161 (CHEMBL4201408) |
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IC50 | 14450±n/a nM |
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Citation | Wang, X; Edwards, RL; Ball, H; Johnson, C; Haymond, A; Girma, M; Manikkam, M; Brothers, RC; McKay, KT; Arnett, SD; Osbourn, DM; Alvarez, S; Boshoff, HI; Meyers, MJ; Couch, RD; Odom John, AR; Dowd, CS MEPicides: ?,?-Unsaturated Fosmidomycin Analogues as DXR Inhibitors against Malaria. J Med Chem61:8847-8858 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic |
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Name: | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic |
Synonyms: | 1-deoxyxylulose-5-phosphate reductoisomerase | DOXP reductoisomerase | DXP reductoisomerase | DXR | DXR_PLAF7 |
Type: | PROTEIN |
Mol. Mass.: | 55772.75 |
Organism: | Plasmodium falciparum (isolate 3D7) |
Description: | ChEMBL_117864 |
Residue: | 488 |
Sequence: | MKKYIYIYFFFITITINDLVINNTSKCVSIERRKNNAYINYGIGYNGPDNKITKSRRCKR
IKLCKKDLIDIGAIKKPINVAIFGSTGSIGTNALNIIRECNKIENVFNVKALYVNKSVNE
LYEQAREFLPEYLCIHDKSVYEELKELVKNIKDYKPIILCGDEGMKEICSSNSIDKIVIG
IDSFQGLYSTMYAIMNNKIVALANKESIVSAGFFLKKLLNIHKNAKIIPVDSEHSAIFQC
LDNNKVLKTKCLQDNFSKINNINKIFLCSSGGPFQNLTMDELKNVTSENALKHPKWKMGK
KITIDSATMMNKGLEVIETHFLFDVDYNDIEVIVHKECIIHSCVEFIDKSVISQMYYPDM
QIPILYSLTWPDRIKTNLKPLDLAQVSTLTFHKPSLEHFPCIKLAYQAGIKGNFYPTVLN
ASNEIANNLFLNNKIKYFDISSIISQVLESFNSQKVSENSEDLMKQILQIHSWAKDKATD
IYNKHNSS
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BDBM50459309 |
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n/a |
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Name | BDBM50459309 |
Synonyms: | CHEMBL4211531 |
Type | Small organic molecule |
Emp. Form. | C5H16N3O6P |
Mol. Mass. | 245.1708 |
SMILES | N.N.COC(=O)N(O)C\C=C\P(O)(O)=O |
Structure |
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