Reaction Details |
| Report a problem with these data |
Target | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic |
---|
Ligand | BDBM50028309 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1766159 (CHEMBL4201406) |
---|
IC50 | 34±n/a nM |
---|
Citation | Wang, X; Edwards, RL; Ball, H; Johnson, C; Haymond, A; Girma, M; Manikkam, M; Brothers, RC; McKay, KT; Arnett, SD; Osbourn, DM; Alvarez, S; Boshoff, HI; Meyers, MJ; Couch, RD; Odom John, AR; Dowd, CS MEPicides: ?,?-Unsaturated Fosmidomycin Analogues as DXR Inhibitors against Malaria. J Med Chem61:8847-8858 (2018) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic |
---|
Name: | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic |
Synonyms: | 1-deoxyxylulose-5-phosphate reductoisomerase | DOXP reductoisomerase | DXP reductoisomerase | DXR | DXR_PLAF7 |
Type: | PROTEIN |
Mol. Mass.: | 55772.75 |
Organism: | Plasmodium falciparum (isolate 3D7) |
Description: | ChEMBL_117864 |
Residue: | 488 |
Sequence: | MKKYIYIYFFFITITINDLVINNTSKCVSIERRKNNAYINYGIGYNGPDNKITKSRRCKR
IKLCKKDLIDIGAIKKPINVAIFGSTGSIGTNALNIIRECNKIENVFNVKALYVNKSVNE
LYEQAREFLPEYLCIHDKSVYEELKELVKNIKDYKPIILCGDEGMKEICSSNSIDKIVIG
IDSFQGLYSTMYAIMNNKIVALANKESIVSAGFFLKKLLNIHKNAKIIPVDSEHSAIFQC
LDNNKVLKTKCLQDNFSKINNINKIFLCSSGGPFQNLTMDELKNVTSENALKHPKWKMGK
KITIDSATMMNKGLEVIETHFLFDVDYNDIEVIVHKECIIHSCVEFIDKSVISQMYYPDM
QIPILYSLTWPDRIKTNLKPLDLAQVSTLTFHKPSLEHFPCIKLAYQAGIKGNFYPTVLN
ASNEIANNLFLNNKIKYFDISSIISQVLESFNSQKVSENSEDLMKQILQIHSWAKDKATD
IYNKHNSS
|
|
|
BDBM50028309 |
---|
n/a |
---|
Name | BDBM50028309 |
Synonyms: | Fosmidomycin Sodium |
Type | Small organic molecule |
Emp. Form. | C4H9NNaO5P |
Mol. Mass. | 205.0815 |
SMILES | [Na+].ON(CCCP(O)([O-])=O)C=O |
Structure |
|