| Reaction Details |
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 | Report a problem with these data |
| Target | Protein AF-9 |
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| Ligand | BDBM50459725 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1767019 (CHEMBL4202266) |
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| Ki | 4250±n/a nM |
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| Citation |  Du, L; Grigsby, SM; Yao, A; Chang, Y; Johnson, G; Sun, H; Nikolovska-Coleska, Z Peptidomimetics for Targeting Protein-Protein Interactions between DOT1L and MLL Oncofusion Proteins AF9 and ENL. ACS Med Chem Lett9:895-900 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein AF-9 |
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| Name: | Protein AF-9 |
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| Synonyms: | AF9 | AF9_HUMAN | ALL1-fused gene from chromosome 9 protein | MLLT3 | Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein | Protein AF-9 | YEATS domain-containing protein 3 | YEATS3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 63368.78 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_118006 |
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| Residue: | 568 |
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| Sequence: | MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFP
RPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPRKVRFDYDLFLHLEGHPPVNHLRCE
KLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS
SSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENK
PLKEEKIVPKMAFKEPKPMSKEPKPDSNLLTITSGQDKKAPSKRPPISDSEELSAKKRKK
SSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVD
PNDSDVEENISSKSDSEQPSPASSSSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESD
EVEDNDNDSEMERPVNRGGSRSRRVSLSDGSDSESSSASSPLHHEPPPPLLKTNNNQILE
VKSPIKQSKSDKQIKNGECDKAYLDELVELHRRLMTLRERHILQQIVNLIEETGHFHITN
TTFDFDLCSLDKTTVRKLQSYLETSGTS
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| BDBM50459725 |
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| n/a |
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| Name | BDBM50459725 |
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| Synonyms: | CHEMBL4204221 |
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| Type | Small organic molecule |
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| Emp. Form. | C43H77N9O8 |
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| Mol. Mass. | 848.127 |
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| SMILES | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N(C)C |r| |
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| Structure | 
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