Reaction Details |
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Target | Renin |
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Ligand | BDBM50022883 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_195945 |
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pH | 6±n/a |
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IC50 | 4±n/a nM |
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Comments | extracted |
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Citation | Luly, JR; Bolis, G; BaMaung, N; Soderquist, J; Dellaria, JF; Stein, H; Cohen, J; Perun, TJ; Greer, J; Plattner, JJ New inhibitors of human renin that contain novel Leu-Val replacements. Examination of the P1 site. J Med Chem31:532-9 (1988) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Renin |
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Name: | Renin |
Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 45058.99 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 406 |
Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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BDBM50022883 |
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n/a |
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Name | BDBM50022883 |
Synonyms: | 1N-[1-[1-cyclohexylmethyl-2-hydroxy-3-isopropylsulfanyl-(1S,2R)-propylcarbamoyl]-2-(1H-5-imidazolyl)-(1S)-ethyl]-2-aminotertiarybutyloxycarbonyl-3-phenyl-(2S)-propanamide | CHEMBL357302 |
Type | Small organic molecule |
Emp. Form. | C33H51N5O5S |
Mol. Mass. | 629.854 |
SMILES | CC(C)SC[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C |
Structure |
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