| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM50023077 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_195933 |
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| IC50 | 1600±n/a nM |
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| Citation |  Bolis, G; Fung, AK; Greer, J; Kleinert, HD; Marcotte, PA; Perun, TJ; Plattner, JJ; Stein, HH Renin inhibitors. Dipeptide analogues of angiotensinogen incorporating transition-state, nonpeptidic replacements at the scissile bond. J Med Chem30:1729-37 (1987) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 45058.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM50023077 |
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| n/a |
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| Name | BDBM50023077 |
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| Synonyms: | (1-{1-[2-Hydroxy-1-isobutyl-4-(propane-2-sulfonyl)-butylcarbamoyl]-ethylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester | CHEMBL301724 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H47N3O7S |
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| Mol. Mass. | 569.754 |
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| SMILES | CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)[C@@H](O)CCS(=O)(=O)C(C)C |
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| Structure | 
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