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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | ||
| Ligand | BDBM50460340 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1769374 (CHEMBL4221486) | ||
| IC50 | 3000±n/a nM | ||
| Citation |  Srinivas, M; Singh Pathania, A; Mahajan, P; Verma, PK; Chobe, SS; Malik, FA; Nargotra, A; Vishwakarma, RA; Sawant, SD Design and synthesis of 1,4-substituted 1H-1,2,3-triazolo-quinazolin-4(3H)-ones by Huisgen 1,3-dipolar cycloaddition with PI3K? isoform selective activity. Bioorg Med Chem Lett28:1005-1010 (2018) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | |||
| Name: | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | ||
| Synonyms: | PI3-kinase p110 subunit gamma | PI3-kinase subunit p120-gamma | PI3Kgamma | PIK3CG | PK3CG_HUMAN | Phosphatidylinositol 4,5-biphosphate 3-kinase catalytic subunit gamma (PIK3CG) | Phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K) | Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma (PI3K gamma) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma (PI3Kgamma) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3K gamma) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3K) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3Kgamma) | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Phosphoinositide 3-Kinase (PI3K), gamma Chain A | Phosphoinositide 3-kinases gamma (PI3K gamma) | Phosphoinositide-3-kinase (PI3K gamma) | p120-PI3K | ||
| Type: | Enzyme Subunit | ||
| Mol. Mass.: | 126470.30 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P48736 | ||
| Residue: | 1102 | ||
| Sequence: |
| ||
| BDBM50460340 | |||
| n/a | |||
| Name | BDBM50460340 | ||
| Synonyms: | CHEMBL4228200 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H25N5O2 | ||
| Mol. Mass. | 451.5197 | ||
| SMILES | COc1ccc(-c2cn(Cc3nc4cccc(C)c4c(=O)n3-c3ccccc3C)nn2)c(C)c1 |(27.62,-21.79,;28.98,-21.07,;30.29,-21.88,;31.65,-21.16,;32.95,-21.98,;32.89,-23.52,;34.2,-24.34,;35.44,-23.43,;36.69,-24.32,;38.15,-23.84,;39.47,-24.63,;39.44,-26.17,;40.76,-26.97,;40.73,-28.51,;42.05,-29.3,;43.4,-28.56,;43.43,-27.02,;44.77,-26.28,;42.11,-26.22,;42.14,-24.69,;43.49,-23.94,;40.82,-23.89,;40.8,-22.35,;42.13,-21.56,;42.11,-20.02,;40.76,-19.27,;39.44,-20.06,;39.46,-21.6,;38.13,-22.38,;36.23,-25.79,;34.69,-25.8,;31.53,-24.24,;31.48,-25.78,;30.23,-23.42,)| | ||
| Structure | 
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