Reaction Details | |||
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Target | Sodium- and chloride-dependent glycine transporter 1 | ||
Ligand | BDBM50460356 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1769377 (CHEMBL4221489) | ||
IC50 | 1.000000±n/a nM | ||
Citation | Varnes, JG; Xiong, H; Forst, JM; Holmquist, CR; Ernst, GE; Frietze, W; Dembofsky, B; Andisik, DW; Palmer, WE; Hinkley, L; Steelman, GB; Wilkins, DE; Tian, G; Jonak, G; Potts, WM; Wang, X; Brugel, TA; Alhambra, C; Wood, MW; Veale, CA; Albert, JS Bicyclo((aryl)methyl)benzamides as inhibitors of GlyT1. Bioorg Med Chem Lett28:1043-1049 (2018) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Sodium- and chloride-dependent glycine transporter 1 | |||
Name: | Sodium- and chloride-dependent glycine transporter 1 | ||
Synonyms: | GlyT-1 | GlyT1 | Glycine Transporters (GlyT1c) | Glycine transporter 1 | SC6A9_HUMAN | SLC6A9 | Sodium- and chloride-dependent glycine transporter 1 | Sodium- and chloride-dependent glycine transporter 1 (GlyT1) | Sodium- and chloride-dependent glycine transporter 1 (GlyT1c) | Sodium-and chloride-dependent glycine transporter 1 (GlyT-1c) | Solute carrier family 6 member 9 | ||
Type: | Enzyme | ||
Mol. Mass.: | 78270.54 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P48067 | ||
Residue: | 706 | ||
Sequence: |
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BDBM50460356 | |||
n/a | |||
Name | BDBM50460356 | ||
Synonyms: | CHEMBL4224734 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H29N3O | ||
Mol. Mass. | 363.4959 | ||
SMILES | CN1CC2CCC1(CC2)C(NC(=O)c1c(C)cccc1C)c1ccncc1 |(37.75,-10.82,;37.75,-9.26,;36.4,-8.49,;36.4,-6.92,;37.75,-6.13,;39.1,-6.92,;39.1,-8.49,;38.49,-7.15,;37.39,-8.26,;40.45,-9.27,;40.45,-10.8,;41.78,-11.58,;43.11,-10.81,;41.78,-13.11,;40.45,-13.87,;39.1,-13.08,;40.44,-15.4,;41.78,-16.18,;43.11,-15.4,;43.1,-13.87,;44.45,-13.09,;41.78,-8.5,;41.78,-6.97,;43.1,-6.2,;44.44,-6.97,;44.44,-8.51,;43.11,-9.27,)| | ||
Structure |