Reaction Details | |||
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Target | Sodium- and chloride-dependent glycine transporter 1 | ||
Ligand | BDBM50460357 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1769377 (CHEMBL4221489) | ||
IC50 | 1.000000±n/a nM | ||
Citation | Varnes, JG; Xiong, H; Forst, JM; Holmquist, CR; Ernst, GE; Frietze, W; Dembofsky, B; Andisik, DW; Palmer, WE; Hinkley, L; Steelman, GB; Wilkins, DE; Tian, G; Jonak, G; Potts, WM; Wang, X; Brugel, TA; Alhambra, C; Wood, MW; Veale, CA; Albert, JS Bicyclo((aryl)methyl)benzamides as inhibitors of GlyT1. Bioorg Med Chem Lett28:1043-1049 (2018) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Sodium- and chloride-dependent glycine transporter 1 | |||
Name: | Sodium- and chloride-dependent glycine transporter 1 | ||
Synonyms: | GlyT-1 | GlyT1 | Glycine Transporters (GlyT1c) | Glycine transporter 1 | SC6A9_HUMAN | SLC6A9 | Sodium- and chloride-dependent glycine transporter 1 | Sodium- and chloride-dependent glycine transporter 1 (GlyT1) | Sodium- and chloride-dependent glycine transporter 1 (GlyT1c) | Sodium-and chloride-dependent glycine transporter 1 (GlyT-1c) | Solute carrier family 6 member 9 | ||
Type: | Enzyme | ||
Mol. Mass.: | 78270.54 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P48067 | ||
Residue: | 706 | ||
Sequence: |
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BDBM50460357 | |||
n/a | |||
Name | BDBM50460357 | ||
Synonyms: | CHEMBL4226364 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H30N2O2 | ||
Mol. Mass. | 366.4965 | ||
SMILES | CN1CC2CCC1(CC2)C(NC(=O)c1c(C)cccc1C)c1ccc(C)o1 |(24.77,-10.28,;24.77,-8.72,;23.42,-7.95,;23.42,-6.39,;24.77,-5.59,;26.13,-6.39,;26.13,-7.95,;25.51,-6.61,;24.41,-7.72,;27.48,-8.73,;27.47,-10.26,;28.8,-11.04,;30.13,-10.27,;28.8,-12.57,;27.47,-13.33,;26.12,-12.54,;27.47,-14.86,;28.8,-15.63,;30.13,-14.86,;30.12,-13.33,;31.47,-12.54,;28.8,-7.96,;28.95,-6.44,;30.45,-6.11,;31.22,-7.44,;32.77,-7.6,;30.2,-8.58,)| | ||
Structure |