| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1/REST corepressor 3 |
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| Ligand | BDBM19149 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1769411 (CHEMBL4221523) |
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| Ki | 3.0±n/a nM |
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| Citation |  Milelli, A; Marchetti, C; Turrini, E; Catanzaro, E; Mazzone, R; Tomaselli, D; Fimognari, C; Tumiatti, V; Minarini, A Novel polyamine-based Histone deacetylases-Lysine demethylase 1 dual binding inhibitors. Bioorg Med Chem Lett28:1001-1004 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1/REST corepressor 3 |
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| Name: | Histone deacetylase 1/REST corepressor 3 |
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| Synonyms: | HDAC1/REST corepressor 3 |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 1769411 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| Component 2 |
| Name: | REST corepressor 3 |
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| Synonyms: | KIAA1343 | RCOR3 | RCOR3_HUMAN | REST corepressor 3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 55589.31 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_118345 |
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| Residue: | 495 |
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| Sequence: | MRVGAEYQARIPEFDPGATKYTDKDNGGMLVWSPYHSIPDAKLDEYIAIAKEKHGYNVEQ
ALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTI
ASLVKYYYSWKKTRSRTSLMDRQARKLANRHNQGDSDDDVEETHPMDGNDSDYDPKKEAK
KEGNTEQPVQTSKIGLGRREYQSLQHRHHSQRSKCRPPKGMYLTQEDVVAVSCSPNAANT
ILRQLDMELISLKRQVQNAKQVNSALKQKMEGGIEEFKPPESNQKINARWTTEEQLLAVQ
GVRKYGKDFQAIADVIGNKTVGQVKNFFVNYRRRFNLEEVLQEWEAEQGTQASNGDASTL
GEETKSASNVPSGKSTDEEEEAQTPQAPRTLGPSPPAPSSTPTPTAPIATLNQPPPLLRP
TLPAAPALHRQPPPLQQQARFIQPRPTLNQPPPPLIRPANSMPPRLNPRPVLSTVGGQQP
PSLIGIQTDSQSSLH
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| BDBM19149 |
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| n/a |
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| Name | BDBM19149 |
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| Synonyms: | CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA | US10011611, SAHA | US10188756, Compound SAHA | US11207431, SAHA | US11505523, Compound SAHA | US9115116, SAHA | US9353061, SAHA | US9428447, SAHA | US9695181, Vorinostat | Vorinostat | Zolinza | cid_5311 | suberoylanilide hydroxamic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C14H20N2O3 |
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| Mol. Mass. | 264.3202 |
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| SMILES | ONC(=O)CCCCCCC(=O)Nc1ccccc1 |
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| Structure | 
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