| Reaction Details |
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 | Report a problem with these data |
| Target | Rhomboid protease GluP |
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| Ligand | BDBM50460514 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1769602 |
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| IC50 | 6200±n/a nM |
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| Citation |  Yang, J; Barniol-Xicota, M; Nguyen, MTN; Ticha, A; Strisovsky, K; Verhelst, SHL Benzoxazin-4-ones as novel, easily accessible inhibitors for rhomboid proteases. Bioorg Med Chem Lett28:1423-1427 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Rhomboid protease GluP |
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| Name: | Rhomboid protease GluP |
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| Synonyms: | 3.4.21.105 | GLUP_BACSU | Intramembrane serine protease | Rhomboid protease GluP | gluP | yqgP | yqgP |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56456.50 |
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| Organism: | Bacillus subtilis (strain 168) |
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| Description: | ChEMBL_117824 |
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| Residue: | 507 |
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| Sequence: | MFLLEYTYWKIAAHLVNSGYGVIQAGESDEIWLEAPDKSSHDLVRLYKHDLDFRQEMVRD
IEEQAERVERVRHQLGRRRMKLLNVFFSTEAPVDDWEEIAKKTFEKGTVSVEPAIVRGTM
LRDDLQAVFPSFRTEDCSEEHASFENAQMARERFLSLVLKQEEQRKTEAAVFQNGKPTFT
YLFIALQILMFFLLEINGGSTNTETLVAFGAKENSLIAQGEWWRLLTPIVLHIGIAHLAF
NTLALWSVGTAVERMYGSGRFLLIYLAAGITGSIASFVFSPYPSAGASGAIFGCLGALLY
VALSNRKMFLRTIGTNIIVIIIINLGFGFAVSNIDNSGHIGGLIGGFFAAAALGLPKAGA
FGKRLLSAVLLIALAVGFLYYGLHSPSHQESALIQQASELYQEGKYEEVTELLNGEAAQK
DASADLLKILAVSDIQIGEYDQAVSLLERAVKKEPKDHASYYNLALLYAEKNELAQAEKA
IQTAVKLKPKEQRYKELQRQIENNKES
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| BDBM50460514 |
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| n/a |
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| Name | BDBM50460514 |
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| Synonyms: | CHEMBL4229256 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H6ClNO3 |
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| Mol. Mass. | 235.623 |
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| SMILES | Clc1cccc2nc(OCC#C)oc(=O)c12 |
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| Structure | 
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