| Reaction Details |
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 | Report a problem with these data |
| Target | Dopamine beta-hydroxylase |
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| Ligand | BDBM50023370 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_50738 (CHEMBL660770) |
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| Ki | 35000±n/a nM |
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| Citation |  Kruse, LI; Kaiser, C; DeWolf, WE; Chambers, PA; Goodhart, PJ; Ezekiel, M; Ohlstein, EH Beta-substituted phenethylamines as high-affinity mechanism-based inhibitors of dopamine beta-hydroxylase. J Med Chem31:704-6 (1988) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Dopamine beta-hydroxylase |
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| Name: | Dopamine beta-hydroxylase |
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| Synonyms: | DBH | DOPO_BOVIN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 68136.39 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_50738 |
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| Residue: | 610 |
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| Sequence: | MQVPSPSVREAASMYGTAVAVFLVILVAALQGSAPAESPFPFHIPLDPEGTLELSWNISY
AQETIYFQLLVRELKAGVLFGMSDRGELENADLVVLWTDRDGAYFGDAWSDQKGQVHLDS
QQDYQLLRAQRTPEGLYLLFKRPFGTCDPNDYLIEDGTVHLVYGFLEEPLRSLESINTSG
LHTGLQRVQLLKPSIPKPALPADTRTMEIRAPDVLIPGQQTTYWCYVTELPDGFPRHHIV
MYEPIVTEGNEALVHHMEVFQCAAEFETIPHFSGPCDSKMKPQRLNFCRHVLAAWALGAK
AFYYPEEAGLAFGGPGSSRFLRLEVHYHNPLVITGRRDSSGIRLYYTAALRRFDAGIMEL
GLAYTPVMAIPPQETAFVLTGYCTDKCTQLALPASGIHIFASQLHTHLTGRKVVTVLARD
GRETEIVNRDNHYSPHFQEIRMLKKVVSVQPGDVLITSCTYNTEDRRLATVGGFGILEEM
CVNYVHYYPQTQLELCKSAVDPGFLHKYFRLVNRFNSEEVCTCPQASVPEQFASVPWNSF
NREVLKALYGFAPISMHCNRSSAVRFQGEWNRQPLPEIVSRLEEPTPHCPASQAQSPAGP
TVLNISGGKG
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|
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| BDBM50023370 |
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| n/a |
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| Name | BDBM50023370 |
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| Synonyms: | 2-Thiophen-2-yl-allylamine | CHEMBL110604 |
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| Type | Small organic molecule |
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| Emp. Form. | C7H9NS |
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| Mol. Mass. | 139.218 |
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| SMILES | NCC(=C)c1cccs1 |
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| Structure | 
|
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