| Reaction Details |
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 | Report a problem with these data |
| Target | Kallikrein-7 |
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| Ligand | BDBM50460884 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1770504 (CHEMBL4222616) |
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| IC50 | 110±n/a nM |
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| Citation |  Murafuji, H; Sakai, H; Goto, M; Oyama, Y; Imajo, S; Sugawara, H; Tomoo, T; Muto, T Structure-based drug design of 1,3,6-trisubstituted 1,4-diazepan-7-ones as selective human kallikrein 7 inhibitors. Bioorg Med Chem Lett28:1371-1375 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kallikrein-7 |
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| Name: | Kallikrein-7 |
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| Synonyms: | KLK7 | KLK7_HUMAN | Kallikrein 7 | Kallikrein-7 | PRSS6 | SCCE | Serine protease 6 | Stratum corneum chymotryptic enzyme | hK7 | hSCCE | kallikrein-7 isoform 1 preproprotein |
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| Type: | PROTEIN |
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| Mol. Mass.: | 27535.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1469257 |
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| Residue: | 253 |
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| Sequence: | MARSLLLPLQILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALLSGNQLHCGGVLV
NERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNS
QARLSSMVKKVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVY
KDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCK
FTKWINDTMKKHR
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| BDBM50460884 |
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| n/a |
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| Name | BDBM50460884 |
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| Synonyms: | CHEMBL4228178 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H40ClN7O3 |
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| Mol. Mass. | 594.147 |
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| SMILES | CCCC[C@H](N1C\C(NC[C@@H](Cc2cc(Cl)ccc2OC)C1=O)=N\N(C)C)C(=O)Nc1cccc(c1)-c1cnn(C)c1 |r| |
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| Structure | 
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