| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor ROR-gamma |
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| Ligand | BDBM50461068 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1770666 (CHEMBL4222778) |
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| IC50 | 210±n/a nM |
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| Citation |  Ouvry, G; Bihl, F; Bouix-Peter, C; Christin, O; Defoin-Platel, C; Deret, S; Feret, C; Froude, D; Hacini-Rachinel, F; Harris, CS; Hervouet, C; Lafitte, G; Luzy, AP; Musicki, B; Orfila, D; Parnet, V; Pascau, C; Pascau, J; Pierre, R; Raffin, C; Rossio, P; Spiesse, D; Taquet, N; Thoreau, E; Vatinel, R; Vial, E; Hennequin, LF Sulfoximines as potent ROR? inverse agonists. Bioorg Med Chem Lett28:1269-1273 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor ROR-gamma |
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| Name: | Nuclear receptor ROR-gamma |
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| Synonyms: | NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 58218.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51449 |
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| Residue: | 518 |
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| Sequence: | MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
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| BDBM50461068 |
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| n/a |
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| Name | BDBM50461068 |
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| Synonyms: | CHEMBL4228069 | US10457637, Compound 24 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H35NO6S2 |
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| Mol. Mass. | 509.679 |
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| SMILES | CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(OCC2CCOCC2)c(c1)S(C)(=O)=O |
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| Structure | 
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