| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine-specific demethylase 4C |
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| Ligand | BDBM263974 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1771180 (CHEMBL4223292) |
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| IC50 | 5.0±n/a nM |
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| Citation |  Nie, Z; Shi, L; Lai, C; O'Connell, SM; Xu, J; Stansfield, RK; Hosfield, DJ; Veal, JM; Stafford, JA Structure-based design and discovery of potent and selective KDM5 inhibitors. Bioorg Med Chem Lett28:1490-1494 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine-specific demethylase 4C |
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| Name: | Lysine-specific demethylase 4C |
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| Synonyms: | GASC-1 protein | GASC1 | Gene amplified in squamous cell carcinoma 1 protein | JHDM3C | JMJD2C | JmjC domain-containing histone demethylation protein 3C | Jumonji domain-containing protein 2C | KDM4C | KDM4C_HUMAN | KIAA0780 |
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| Type: | Protein |
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| Mol. Mass.: | 119979.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9H3R0 |
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| Residue: | 1056 |
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| Sequence: | MEVAEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRAGLAKVIPPKEWKPRQC
YDDIDNLLIPAPIQQMVTGQSGLFTQYNIQKKAMTVKEFRQLANSGKYCTPRYLDYEDLE
RKYWKNLTFVAPIYGADINGSIYDEGVDEWNIARLNTVLDVVEEECGISIEGVNTPYLYF
GMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQGFFPSSSQGCDAFL
RHKMTLISPSVLKKYGIPFDKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRWID
YGKVAKLCTCRKDMVKISMDIFVRKFQPDRYQLWKQGKDIYTIDHTKPTPASTPEVKAWL
QRRRKVRKASRSFQCARSTSKRPKADEEEEVSDEVDGAEVPNPDSVTDDLKVSEKSEAAV
KLRNTEASSEEESSASRMQVEQNLSDHIKLSGNSCLSTSVTEDIKTEDDKAYAYRSVPSI
SSEADDSIPLSSGYEKPEKSDPSELSWPKSPESCSSVAESNGVLTEGEESDVESHGNGLE
PGEIPAVPSGERNSFKVPSIAEGENKTSKSWRHPLSRPPARSPMTLVKQQAPSDEELPEV
LSIEEEVEETESWAKPLIHLWQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPDSS
NEENDARWETKLDEVVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAK
CCVRVHASCYGIPSHEICDGWLCARCKRNAWTAECCLCNLRGGALKQTKNNKWAHVMCAV
AVPEVRFTNVPERTQIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPASFHVTC
AHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVM
AVTSQTFYEVMFDDGSFSRDTFPEDIVSRDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGS
NIAHMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADIIQGER
KRQRVLSSRFKNEYVADPVYRTFLKSSFQKKCQKRQ
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| BDBM263974 |
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| n/a |
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| Name | BDBM263974 |
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| Synonyms: | 2-(5-(benzyloxy)-1H-pyrazol-1- yl)isonicotinic acid | US10173996, Example 39 | US9604961, Example 39 | US9714230, 39 | US9908865, Example 39 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H13N3O3 |
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| Mol. Mass. | 295.2927 |
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| SMILES | OC(=O)c1ccnc(c1)-n1nccc1OCc1ccccc1 |
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| Structure | 
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