| Reaction Details |
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 | Report a problem with these data |
| Target | Plasmepsin I |
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| Ligand | BDBM50461479 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1771432 (CHEMBL4223544) |
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| IC50 | 1000±n/a nM |
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| Citation |  Rasina, D; Stakanovs, G; Borysov, OV; Pantelejevs, T; Bobrovs, R; Kanepe-Lapsa, I; Tars, K; Jaudzems, K; Jirgensons, A 2-Aminoquinazolin-4(3H)-one based plasmepsin inhibitors with improved hydrophilicity and selectivity. Bioorg Med Chem26:2488-2500 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Plasmepsin I |
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| Name: | Plasmepsin I |
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| Synonyms: | PFAPG | PLM1_PLAFX | PMI | Plasmepsin 1 | Plasmepsin-1 precursor |
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| Type: | Enzyme |
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| Mol. Mass.: | 51463.30 |
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| Organism: | Plasmodium falciparum |
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| Description: | n/a |
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| Residue: | 452 |
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| Sequence: | MALSIKEDFSSAFAKNESAVNSSTFNNNMKTWKIQKRFQILYVFFFLLITGALFYYLIDN
VLFPKNKKINEIMNTSKHVIIGFSIENSHDRIMKTVKQHRLKNYIKESLKFFKTGLTQKP
HLGNAGDSVTLNDVANVMYYGEAQIGDNKQKFAFIFDTGSANLWVPSAQCNTIGCKTKNL
YDSNKSKTYEKDGTKVEMNYVSGTVSGFFSKDIVTIANLSFPYKFIEVTDTNGFEPAYTL
GQFDGIVGLGWKDLSIGSVDPVVVELKNQNKIEQAVFTFYLPFDDKHKGYLTIGGIEDRF
YEGQLTYEKLNHDLYWQVDLDLHFGNLTVEKATAIVDSGTSSITAPTEFLNKFFEGLDVV
KIPFLPLYITTCNNPKLPTLEFRSATNVYTLEPEYYLQQIFDFGISLCMVSIIPVDLNKN
TFILGDPFMRKYFTVFDYDNHTVGFALAKKKL
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| BDBM50461479 |
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| n/a |
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| Name | BDBM50461479 |
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| Synonyms: | CHEMBL4229013 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H23N3O4 |
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| Mol. Mass. | 441.4785 |
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| SMILES | Nc1nc2cc(cc(-c3cccc(c3)C(O)=O)c2c(=O)n1CC1CCCO1)-c1ccccc1 |
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| Structure | 
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