| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50023682 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_217876 |
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| Ki | >0.004±n/a nM |
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| Citation |  Su, TL; Huang, JT; Chou, TC; Otter, GM; Sirotnak, FM; Watanabe, KA Chemical synthesis and biological activities of 5-deazaaminopterin analogues bearing substituent(s) at the 5- and/or 7-position(s). J Med Chem31:1209-15 (1988) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DYR_MOUSE | Dhfr |
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| Type: | Enzyme |
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| Mol. Mass.: | 21608.82 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | n/a |
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| Residue: | 187 |
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| Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKF
EVYEKKD
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|
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| BDBM50023682 |
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| n/a |
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| Name | BDBM50023682 |
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| Synonyms: | 2-{4-[(2,4-Diamino-5-methyl-7-phenyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid | CHEMBL20423 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H27N7O5 |
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| Mol. Mass. | 529.5472 |
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| SMILES | Cc1c(CNc2ccc(cc2)C(=O)NC(CCC(O)=O)C(O)=O)c(nc2nc(N)nc(N)c12)-c1ccccc1 |
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| Structure | 
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