| Reaction Details |
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 | Report a problem with these data |
| Target | Serine palmitoyltransferase 2 |
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| Ligand | BDBM50461641 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1771688 (CHEMBL4223800) |
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| IC50 | 5.1±n/a nM |
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| Citation |  Kojima, T; Asano, Y; Kurasawa, O; Hirata, Y; Iwamura, N; Wong, TT; Saito, B; Tanaka, Y; Arai, R; Yonemori, K; Miyamoto, Y; Sagiya, Y; Yaguchi, M; Shibata, S; Mizutani, A; Sano, O; Adachi, R; Satomi, Y; Hirayama, M; Aoyama, K; Hiura, Y; Kiba, A; Kitamura, S; Imamura, S Discovery of novel serine palmitoyltransferase inhibitors as cancer therapeutic agents. Bioorg Med Chem26:2452-2465 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine palmitoyltransferase 2 |
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| Name: | Serine palmitoyltransferase 2 |
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| Synonyms: | KIAA0526 | LCB 2 | LCB2 | LCB2a | Long chain base biosynthesis protein 2 | Long chain base biosynthesis protein 2a | SPT 2 | SPTC2_HUMAN | SPTLC2 | Serine-palmitoyl-CoA transferase 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 62932.15 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_660504 |
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| Residue: | 562 |
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| Sequence: | MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQNGGLYKRPFN
EAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFEN
FYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLG
FARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFA
TNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQ
PRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVV
EYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQII
TSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIG
AFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYS
RHRLVPLLDRPFDETTYEETED
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| BDBM50461641 |
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| n/a |
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| Name | BDBM50461641 |
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| Synonyms: | CHEMBL4225192 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22Cl2N2O4 |
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| Mol. Mass. | 485.359 |
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| SMILES | COc1ccc(cc1OC)C(=O)N1CCC(NC(=O)c2ccccc2Cl)c2ccc(Cl)cc12 |
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| Structure | 
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