Compile Data Set for Download or QSAR

Found 137 hits with Last Name = 'iwamura' and Initial = 'n'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine palmitoyltransferase 2 (Homo sapiens (Human))	BDBM50461646 (CHEBI:582124 | Myriocin) Show SMILES CCCCCCC(=O)CCCCCC\C=C\C[C@@H](O)[C@H](O)[C@@](N)(CO)C(O)=O |r| Show InChI InChI=1S/C21H39NO6/c1-2-3-4-10-13-17(24)14-11-8-6-5-7-9-12-15-18(25)19(26)21(22,16-23)20(27)28/h9,12,18-19,23,25-26H,2-8,10-11,13-16,22H2,1H3,(H,27,28)/b12-9+/t18-,19+,21+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	0.130	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of human SPT2 transfected in Freestyle293 cells using L-serine and palmitoyl-CoA as substrate preincubated for 60 mins followed by substra...				Bioorg Med Chem 26: 2452-2465 (2018) Article DOI: 10.1016/j.bmc.2018.04.008 BindingDB Entry DOI: 10.7270/Q2RF5XNH
					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclin-C (Homo sapiens (Human))	BDBM50248627 (CHEMBL4078454) Show SMILES OC[C@H](Nc1cncc(n1)-c1ccc(O)c(Cl)c1)c1ccccc1 |r| Show InChI InChI=1S/C18H16ClN3O2/c19-14-8-13(6-7-17(14)24)15-9-20-10-18(21-15)22-16(11-23)12-4-2-1-3-5-12/h1-10,16,23-24H,11H2,(H,21,22)/t16-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human His-tagged CDK8/Cyclin C expressed in baculovirus expression system using Ulight-GS peptide as substrate ...				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50248633 (CHEMBL4083552) Show SMILES NC(=O)c1sc(Oc2ccccc2)c-2c1CCc1cnsc-21 Show InChI InChI=1S/C16H12N2O2S2/c17-15(19)14-11-7-6-9-8-18-22-13(9)12(11)16(21-14)20-10-4-2-1-3-5-10/h1-5,8H,6-7H2,(H2,17,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.340	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Serine palmitoyltransferase 2 (Homo sapiens (Human))	BDBM50461644 (CHEMBL4228416) Show SMILES COc1ccc(cc1OC)C(=O)N1CC[C@@H](NC(=O)c2ccccc2Cl)[C@H](C1)c1ccccc1 |r| Show InChI InChI=1S/C27H27ClN2O4/c1-33-24-13-12-19(16-25(24)34-2)27(32)30-15-14-23(21(17-30)18-8-4-3-5-9-18)29-26(31)20-10-6-7-11-22(20)28/h3-13,16,21,23H,14-15,17H2,1-2H3,(H,29,31)/t21-,23-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.360	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of human SPT2 transfected in Freestyle293 cells using L-serine and palmitoyl-CoA as substrate preincubated for 60 mins followed by substra...				Bioorg Med Chem 26: 2452-2465 (2018) Article DOI: 10.1016/j.bmc.2018.04.008 BindingDB Entry DOI: 10.7270/Q2RF5XNH
					More data for this Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19 (Homo sapiens (Human))	BDBM50248645 (CHEMBL4061525) Show SMILES CNc1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)cn1 Show InChI InChI=1S/C16H14N4O2S2/c1-18-11-5-3-9(7-19-11)22-16-12-10(14(23-16)15(17)21)4-2-8-6-20-24-13(8)12/h3,5-7H,2,4H2,1H3,(H2,17,21)(H,18,19)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.360	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50248623 (CHEMBL4096487) Show SMILES OC[C@H](Nc1cncc(c1)-c1ccc2[nH]ncc2c1)c1ccccc1 |r| Show InChI InChI=1S/C20H18N4O/c25-13-20(14-4-2-1-3-5-14)23-18-9-16(10-21-12-18)15-6-7-19-17(8-15)11-22-24-19/h1-12,20,23,25H,13H2,(H,22,24)/t20-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human His-tagged CDK8/Cyclin C expressed in baculovirus expression system using Ulight-GS peptide as substrate ...				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50248614 (CHEMBL4066819) Show SMILES COCCNC(=O)c1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)cn1 Show InChI InChI=1S/C19H18N4O4S2/c1-26-7-6-21-18(25)13-5-3-11(9-22-13)27-19-14-12(16(28-19)17(20)24)4-2-10-8-23-29-15(10)14/h3,5,8-9H,2,4,6-7H2,1H3,(H2,20,24)(H,21,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.460	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50248635 (CHEMBL4070408) Show SMILES Cc1ncccc1Oc1sc(C(N)=O)c2CCc3cnsc3-c12 Show InChI InChI=1S/C16H13N3O2S2/c1-8-11(3-2-6-18-8)21-16-12-10(14(22-16)15(17)20)5-4-9-7-19-23-13(9)12/h2-3,6-7H,4-5H2,1H3,(H2,17,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.470	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Serine palmitoyltransferase 2 (Homo sapiens (Human))	BDBM50461649 (CHEMBL4225519) Show SMILES COc1cc(cnc1OC)C(=O)N1CC[C@H](NC(=O)c2ccccc2OC(F)(F)F)c2c1cnn2C(C)C |r| Show InChI InChI=1S/C25H26F3N5O5/c1-14(2)33-21-17(31-22(34)16-7-5-6-8-19(16)38-25(26,27)28)9-10-32(18(21)13-30-33)24(35)15-11-20(36-3)23(37-4)29-12-15/h5-8,11-14,17H,9-10H2,1-4H3,(H,31,34)/t17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.540	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of human SPT2 transfected in Freestyle293 cells using L-serine and palmitoyl-CoA as substrate preincubated for 60 mins followed by substra...				Bioorg Med Chem 26: 2452-2465 (2018) Article DOI: 10.1016/j.bmc.2018.04.008 BindingDB Entry DOI: 10.7270/Q2RF5XNH
					More data for this Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19 (Homo sapiens (Human))	BDBM50248633 (CHEMBL4083552) Show SMILES NC(=O)c1sc(Oc2ccccc2)c-2c1CCc1cnsc-21 Show InChI InChI=1S/C16H12N2O2S2/c17-15(19)14-11-7-6-9-8-18-22-13(9)12(11)16(21-14)20-10-4-2-1-3-5-10/h1-5,8H,6-7H2,(H2,17,19)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.550	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19 (Homo sapiens (Human))	BDBM50248656 (CHEMBL4086487) Show SMILES CC(=O)Nc1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)cn1 Show InChI InChI=1S/C17H14N4O3S2/c1-8(22)21-12-5-3-10(7-19-12)24-17-13-11(15(25-17)16(18)23)4-2-9-6-20-26-14(9)13/h3,5-7H,2,4H2,1H3,(H2,18,23)(H,19,21,22)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.570	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50248656 (CHEMBL4086487) Show SMILES CC(=O)Nc1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)cn1 Show InChI InChI=1S/C17H14N4O3S2/c1-8(22)21-12-5-3-10(7-19-12)24-17-13-11(15(25-17)16(18)23)4-2-9-6-20-26-14(9)13/h3,5-7H,2,4H2,1H3,(H2,18,23)(H,19,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.570	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50248645 (CHEMBL4061525) Show SMILES CNc1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)cn1 Show InChI InChI=1S/C16H14N4O2S2/c1-18-11-5-3-9(7-19-11)22-16-12-10(14(23-16)15(17)21)4-2-8-6-20-24-13(8)12/h3,5-7H,2,4H2,1H3,(H2,17,21)(H,18,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.590	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50248640 (CHEMBL4074204) Show SMILES NC(=O)c1sc(Oc2ccc(N)nc2)c-2c1CCc1cnsc-21 Show InChI InChI=1S/C15H12N4O2S2/c16-10-4-2-8(6-18-10)21-15-11-9(13(22-15)14(17)20)3-1-7-5-19-23-12(7)11/h2,4-6H,1,3H2,(H2,16,18)(H2,17,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50248690 (CHEMBL4082469) Show SMILES CSc1sc(C(N)=O)c2CCc3cnsc3-c12 Show InChI InChI=1S/C11H10N2OS3/c1-15-11-7-6(9(16-11)10(12)14)3-2-5-4-13-17-8(5)7/h4H,2-3H2,1H3,(H2,12,14)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.650	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Serine palmitoyltransferase 2 (Homo sapiens (Human))	BDBM50461645 (CHEMBL4228472) Show SMILES Cn1nc(cc1C(=O)N[C@@H]1CCN(C[C@@H]1c1ccccc1)C(=O)c1cc(Cl)c2nccnc2c1)C(F)(F)F |r| Show InChI InChI=1S/C26H22ClF3N6O2/c1-35-21(13-22(34-35)26(28,29)30)24(37)33-19-7-10-36(14-17(19)15-5-3-2-4-6-15)25(38)16-11-18(27)23-20(12-16)31-8-9-32-23/h2-6,8-9,11-13,17,19H,7,10,14H2,1H3,(H,33,37)/t17-,19-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.710	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of human SPT2 transfected in Freestyle293 cells using L-serine and palmitoyl-CoA as substrate preincubated for 60 mins followed by substra...				Bioorg Med Chem 26: 2452-2465 (2018) Article DOI: 10.1016/j.bmc.2018.04.008 BindingDB Entry DOI: 10.7270/Q2RF5XNH
					More data for this Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19 (Homo sapiens (Human))	BDBM50248635 (CHEMBL4070408) Show SMILES Cc1ncccc1Oc1sc(C(N)=O)c2CCc3cnsc3-c12 Show InChI InChI=1S/C16H13N3O2S2/c1-8-11(3-2-6-18-8)21-16-12-10(14(22-16)15(17)20)5-4-9-7-19-23-13(9)12/h2-3,6-7H,4-5H2,1H3,(H2,17,20)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.770	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50248611 (CHEMBL4060856) Show SMILES NC(=O)c1sc(Oc2ccc(nc2)C(N)=O)c-2c1CCc1cnsc-21 Show InChI InChI=1S/C16H12N4O3S2/c17-14(21)10-4-2-8(6-19-10)23-16-11-9(13(24-16)15(18)22)3-1-7-5-20-25-12(7)11/h2,4-6H,1,3H2,(H2,17,21)(H2,18,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.930	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19 (Homo sapiens (Human))	BDBM50248611 (CHEMBL4060856) Show SMILES NC(=O)c1sc(Oc2ccc(nc2)C(N)=O)c-2c1CCc1cnsc-21 Show InChI InChI=1S/C16H12N4O3S2/c17-14(21)10-4-2-8(6-19-10)23-16-11-9(13(24-16)15(18)22)3-1-7-5-20-25-12(7)11/h2,4-6H,1,3H2,(H2,17,21)(H2,18,22)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.970	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50248638 (CHEMBL4062244) Show SMILES Cc1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)cn1 Show InChI InChI=1S/C16H13N3O2S2/c1-8-2-4-10(7-18-8)21-16-12-11(14(22-16)15(17)20)5-3-9-6-19-23-13(9)12/h2,4,6-7H,3,5H2,1H3,(H2,17,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.990	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19 (Homo sapiens (Human))	BDBM50248614 (CHEMBL4066819) Show SMILES COCCNC(=O)c1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)cn1 Show InChI InChI=1S/C19H18N4O4S2/c1-26-7-6-21-18(25)13-5-3-11(9-22-13)27-19-14-12(16(28-19)17(20)24)4-2-10-8-23-29-15(10)14/h3,5,8-9H,2,4,6-7H2,1H3,(H2,20,24)(H,21,25)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.990	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19 (Homo sapiens (Human))	BDBM50248612 (CHEMBL4076395) Show SMILES CNC(=O)c1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)cn1 Show InChI InChI=1S/C17H14N4O3S2/c1-19-16(23)11-5-3-9(7-20-11)24-17-12-10(14(25-17)15(18)22)4-2-8-6-21-26-13(8)12/h3,5-7H,2,4H2,1H3,(H2,18,22)(H,19,23)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50248615 (CHEMBL4077627) Show SMILES CCOCCNC(=O)c1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)cn1 Show InChI InChI=1S/C20H20N4O4S2/c1-2-27-8-7-22-19(26)14-6-4-12(10-23-14)28-20-15-13(17(29-20)18(21)25)5-3-11-9-24-30-16(11)15/h4,6,9-10H,2-3,5,7-8H2,1H3,(H2,21,25)(H,22,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19 (Homo sapiens (Human))	BDBM50248640 (CHEMBL4074204) Show SMILES NC(=O)c1sc(Oc2ccc(N)nc2)c-2c1CCc1cnsc-21 Show InChI InChI=1S/C15H12N4O2S2/c16-10-4-2-8(6-18-10)21-15-11-9(13(22-15)14(17)20)3-1-7-5-19-23-12(7)11/h2,4-6H,1,3H2,(H2,16,18)(H2,17,20)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Serine palmitoyltransferase 2 (Homo sapiens (Human))	BDBM50461647 (CHEMBL4225462) Show SMILES COc1cc(cnc1OC)C(=O)N1CCC(NC(=O)c2ccccc2OC(F)(F)F)c2c1cnn2C(C)C Show InChI InChI=1S/C25H26F3N5O5/c1-14(2)33-21-17(31-22(34)16-7-5-6-8-19(16)38-25(26,27)28)9-10-32(18(21)13-30-33)24(35)15-11-20(36-3)23(37-4)29-12-15/h5-8,11-14,17H,9-10H2,1-4H3,(H,31,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of human SPT2 transfected in Freestyle293 cells using L-serine and palmitoyl-CoA as substrate preincubated for 60 mins followed by substra...				Bioorg Med Chem 26: 2452-2465 (2018) Article DOI: 10.1016/j.bmc.2018.04.008 BindingDB Entry DOI: 10.7270/Q2RF5XNH
					More data for this Ligand-Target Pair
Serine palmitoyltransferase 2 (Homo sapiens (Human))	BDBM50461643 (CHEMBL4225764) Show SMILES COc1ccc(cc1OC)C(=O)N1CCC(NC(=O)c2ccccc2Cl)C(C1)c1ccccc1 Show InChI InChI=1S/C27H27ClN2O4/c1-33-24-13-12-19(16-25(24)34-2)27(32)30-15-14-23(21(17-30)18-8-4-3-5-9-18)29-26(31)20-10-6-7-11-22(20)28/h3-13,16,21,23H,14-15,17H2,1-2H3,(H,29,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of human SPT2 transfected in Freestyle293 cells using L-serine and palmitoyl-CoA as substrate preincubated for 60 mins followed by substra...				Bioorg Med Chem 26: 2452-2465 (2018) Article DOI: 10.1016/j.bmc.2018.04.008 BindingDB Entry DOI: 10.7270/Q2RF5XNH
					More data for this Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19 (Homo sapiens (Human))	BDBM50248690 (CHEMBL4082469) Show SMILES CSc1sc(C(N)=O)c2CCc3cnsc3-c12 Show InChI InChI=1S/C11H10N2OS3/c1-15-11-7-6(9(16-11)10(12)14)3-2-5-4-13-17-8(5)7/h4H,2-3H2,1H3,(H2,12,14)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19 (Homo sapiens (Human))	BDBM50248638 (CHEMBL4062244) Show SMILES Cc1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)cn1 Show InChI InChI=1S/C16H13N3O2S2/c1-8-2-4-10(7-18-8)21-16-12-11(14(22-16)15(17)20)5-3-9-6-19-23-13(9)12/h2,4,6-7H,3,5H2,1H3,(H2,17,20)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19 (Homo sapiens (Human))	BDBM50248686 (CHEMBL4071040) Show SMILES COCCNC(=O)c1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)c(C)n1 Show InChI InChI=1S/C20H20N4O4S2/c1-10-14(6-5-13(24-10)19(26)22-7-8-27-2)28-20-15-12(17(29-20)18(21)25)4-3-11-9-23-30-16(11)15/h5-6,9H,3-4,7-8H2,1-2H3,(H2,21,25)(H,22,26)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50248686 (CHEMBL4071040) Show SMILES COCCNC(=O)c1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)c(C)n1 Show InChI InChI=1S/C20H20N4O4S2/c1-10-14(6-5-13(24-10)19(26)22-7-8-27-2)28-20-15-12(17(29-20)18(21)25)4-3-11-9-23-30-16(11)15/h5-6,9H,3-4,7-8H2,1-2H3,(H2,21,25)(H,22,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50248662 (CHEMBL4091345) Show SMILES NC(=O)c1sc(Oc2cccnc2)c-2c1CCc1cnsc-21 Show InChI InChI=1S/C15H11N3O2S2/c16-14(19)13-10-4-3-8-6-18-22-12(8)11(10)15(21-13)20-9-2-1-5-17-7-9/h1-2,5-7H,3-4H2,(H2,16,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19 (Homo sapiens (Human))	BDBM50248615 (CHEMBL4077627) Show SMILES CCOCCNC(=O)c1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)cn1 Show InChI InChI=1S/C20H20N4O4S2/c1-2-27-8-7-22-19(26)14-6-4-12(10-23-14)28-20-15-13(17(29-20)18(21)25)5-3-11-9-24-30-16(11)15/h4,6,9-10H,2-3,5,7-8H2,1H3,(H2,21,25)(H,22,26)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50248612 (CHEMBL4076395) Show SMILES CNC(=O)c1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)cn1 Show InChI InChI=1S/C17H14N4O3S2/c1-19-16(23)11-5-3-9(7-20-11)24-17-12-10(14(25-17)15(18)22)4-2-8-6-21-26-13(8)12/h3,5-7H,2,4H2,1H3,(H2,18,22)(H,19,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50248632 (CHEMBL4069854) Show SMILES COc1sc(C(N)=O)c2CCc3cnsc3-c12 Show InChI InChI=1S/C11H10N2O2S2/c1-15-11-7-6(9(16-11)10(12)14)3-2-5-4-13-17-8(5)7/h4H,2-3H2,1H3,(H2,12,14)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19 (Homo sapiens (Human))	BDBM50248687 (CHEMBL4090775) Show SMILES CC(C)(O)CNC(=O)c1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)cn1 Show InChI InChI=1S/C20H20N4O4S2/c1-20(2,27)9-23-18(26)13-6-4-11(8-22-13)28-19-14-12(16(29-19)17(21)25)5-3-10-7-24-30-15(10)14/h4,6-8,27H,3,5,9H2,1-2H3,(H2,21,25)(H,23,26)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50248687 (CHEMBL4090775) Show SMILES CC(C)(O)CNC(=O)c1ccc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)cn1 Show InChI InChI=1S/C20H20N4O4S2/c1-20(2,27)9-23-18(26)13-6-4-11(8-22-13)28-19-14-12(16(29-19)17(21)25)5-3-10-7-24-30-15(10)14/h4,6-8,27H,3,5,9H2,1-2H3,(H2,21,25)(H,23,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19 (Homo sapiens (Human))	BDBM50248662 (CHEMBL4091345) Show SMILES NC(=O)c1sc(Oc2cccnc2)c-2c1CCc1cnsc-21 Show InChI InChI=1S/C15H11N3O2S2/c16-14(19)13-10-4-3-8-6-18-22-12(8)11(10)15(21-13)20-9-2-1-5-17-7-9/h1-2,5-7H,3-4H2,(H2,16,19)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19 (Homo sapiens (Human))	BDBM50248632 (CHEMBL4069854) Show SMILES COc1sc(C(N)=O)c2CCc3cnsc3-c12 Show InChI InChI=1S/C11H10N2O2S2/c1-15-11-7-6(9(16-11)10(12)14)3-2-5-4-13-17-8(5)7/h4H,2-3H2,1H3,(H2,12,14)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 9 (Homo sapiens (Human))	BDBM50248690 (CHEMBL4082469) Show SMILES CSc1sc(C(N)=O)c2CCc3cnsc3-c12 Show InChI InChI=1S/C11H10N2OS3/c1-15-11-7-6(9(16-11)10(12)14)3-2-5-4-13-17-8(5)7/h4H,2-3H2,1H3,(H2,12,14)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of CDK9 (unknown origin)				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50248609 (CHEMBL4088931) Show SMILES Cc1c(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)ccc[n+]1[O-] Show InChI InChI=1S/C16H13N3O3S2/c1-8-11(3-2-6-19(8)21)22-16-12-10(14(23-16)15(17)20)5-4-9-7-18-24-13(9)12/h2-3,6-7H,4-5H2,1H3,(H2,17,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50248658 (CHEMBL4060714) Show SMILES Cc1ccncc1Oc1sc(C(N)=O)c2CCc3cnsc3-c12 Show InChI InChI=1S/C16H13N3O2S2/c1-8-4-5-18-7-11(8)21-16-12-10(14(22-16)15(17)20)3-2-9-6-19-23-13(9)12/h4-7H,2-3H2,1H3,(H2,17,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Serine palmitoyltransferase 2 (Homo sapiens (Human))	BDBM50461639 (CHEMBL4229253) Show SMILES COc1ccc(cc1OC)C(=O)N1CC[C@@H](NC(=O)c2ccccc2Cl)[C@@H](C1)c1ccccc1 |r| Show InChI InChI=1S/C27H27ClN2O4/c1-33-24-13-12-19(16-25(24)34-2)27(32)30-15-14-23(21(17-30)18-8-4-3-5-9-18)29-26(31)20-10-6-7-11-22(20)28/h3-13,16,21,23H,14-15,17H2,1-2H3,(H,29,31)/t21-,23+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of human SPT2 transfected in Freestyle293 cells using L-serine and palmitoyl-CoA as substrate preincubated for 60 mins followed by substra...				Bioorg Med Chem 26: 2452-2465 (2018) Article DOI: 10.1016/j.bmc.2018.04.008 BindingDB Entry DOI: 10.7270/Q2RF5XNH
					More data for this Ligand-Target Pair
Serine palmitoyltransferase 2 (Homo sapiens (Human))	BDBM50461641 (CHEMBL4225192) Show SMILES COc1ccc(cc1OC)C(=O)N1CCC(NC(=O)c2ccccc2Cl)c2ccc(Cl)cc12 Show InChI InChI=1S/C25H22Cl2N2O4/c1-32-22-10-7-15(13-23(22)33-2)25(31)29-12-11-20(18-9-8-16(26)14-21(18)29)28-24(30)17-5-3-4-6-19(17)27/h3-10,13-14,20H,11-12H2,1-2H3,(H,28,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of human SPT2 transfected in Freestyle293 cells using L-serine and palmitoyl-CoA as substrate preincubated for 60 mins followed by substra...				Bioorg Med Chem 26: 2452-2465 (2018) Article DOI: 10.1016/j.bmc.2018.04.008 BindingDB Entry DOI: 10.7270/Q2RF5XNH
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50248639 (CHEMBL4072372) Show SMILES Cc1cncc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)c1 Show InChI InChI=1S/C16H13N3O2S2/c1-8-4-10(7-18-5-8)21-16-12-11(14(22-16)15(17)20)3-2-9-6-19-23-13(9)12/h4-7H,2-3H2,1H3,(H2,17,20)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19 (Homo sapiens (Human))	BDBM50248658 (CHEMBL4060714) Show SMILES Cc1ccncc1Oc1sc(C(N)=O)c2CCc3cnsc3-c12 Show InChI InChI=1S/C16H13N3O2S2/c1-8-4-5-18-7-11(8)21-16-12-10(14(22-16)15(17)20)3-2-9-6-19-23-13(9)12/h4-7H,2-3H2,1H3,(H2,17,20)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.60	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50248628 (CHEMBL4072496) Show SMILES NC(=O)c1[nH]cc(c1Cl)-c1ccncc1 Show InChI InChI=1S/C10H8ClN3O/c11-8-7(5-14-9(8)10(12)15)6-1-3-13-4-2-6/h1-5,14H,(H2,12,15)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human His-tagged CDK8/Cyclin C expressed in baculovirus expression system using Ulight-GS peptide as substrate ...				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine palmitoyltransferase 2 (Homo sapiens (Human))	BDBM50461638 (CHEMBL4226297) Show SMILES COc1ccc(cc1OC)C(=O)N1CCC(NC(=O)c2ccccc2Cl)c2c1cnn2C Show InChI InChI=1S/C23H23ClN4O4/c1-27-21-17(26-22(29)15-6-4-5-7-16(15)24)10-11-28(18(21)13-25-27)23(30)14-8-9-19(31-2)20(12-14)32-3/h4-9,12-13,17H,10-11H2,1-3H3,(H,26,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.70	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of human SPT2 transfected in Freestyle293 cells using L-serine and palmitoyl-CoA as substrate preincubated for 60 mins followed by substra...				Bioorg Med Chem 26: 2452-2465 (2018) Article DOI: 10.1016/j.bmc.2018.04.008 BindingDB Entry DOI: 10.7270/Q2RF5XNH
					More data for this Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19 (Homo sapiens (Human))	BDBM50248639 (CHEMBL4072372) Show SMILES Cc1cncc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)c1 Show InChI InChI=1S/C16H13N3O2S2/c1-8-4-10(7-18-5-8)21-16-12-11(14(22-16)15(17)20)3-2-9-6-19-23-13(9)12/h4-7H,2-3H2,1H3,(H2,17,20)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.20	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50248678 (CHEMBL4062262) Show SMILES CNC(=O)c1sc(SC)c-2c1CCc1cnsc-21 Show InChI InChI=1S/C12H12N2OS3/c1-13-11(15)10-7-4-3-6-5-14-18-9(6)8(7)12(16-2)17-10/h5H,3-4H2,1-2H3,(H,13,15)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.30	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19 (Homo sapiens (Human))	BDBM50248609 (CHEMBL4088931) Show SMILES Cc1c(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)ccc[n+]1[O-] Show InChI InChI=1S/C16H13N3O3S2/c1-8-11(3-2-6-19(8)21)22-16-12-10(14(23-16)15(17)20)5-4-9-7-18-24-13(9)12/h2-3,6-7H,4-5H2,1H3,(H2,17,20)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.30	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assay				Bioorg Med Chem 25: 2336-2350 (2017) Article DOI: 10.1016/j.bmc.2017.02.038 BindingDB Entry DOI: 10.7270/Q21J9D6H
					More data for this Ligand-Target Pair

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