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TargetSerine palmitoyltransferase 2
LigandBDBM50461646
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1771688 (CHEMBL4223800)
IC50 0.130000±n/a nM
Citation Kojima, T; Asano, Y; Kurasawa, O; Hirata, Y; Iwamura, N; Wong, TT; Saito, B; Tanaka, Y; Arai, R; Yonemori, K; Miyamoto, Y; Sagiya, Y; Yaguchi, M; Shibata, S; Mizutani, A; Sano, O; Adachi, R; Satomi, Y; Hirayama, M; Aoyama, K; Hiura, Y; Kiba, A; Kitamura, S; Imamura, S Discovery of novel serine palmitoyltransferase inhibitors as cancer therapeutic agents. Bioorg Med Chem26:2452-2465 (2018) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serine palmitoyltransferase 2
Name:Serine palmitoyltransferase 2
Synonyms:KIAA0526 | LCB 2 | LCB2 | LCB2a | Long chain base biosynthesis protein 2 | Long chain base biosynthesis protein 2a | SPT 2 | SPTC2_HUMAN | SPTLC2 | Serine-palmitoyl-CoA transferase 2
Type:PROTEIN
Mol. Mass.:62932.15
Organism:Homo sapiens (Human)
Description:ChEMBL_660504
Residue:562
Sequence:
MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQNGGLYKRPFN
EAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFEN
FYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLG
FARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFA
TNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQ
PRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVV
EYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQII
TSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIG
AFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYS
RHRLVPLLDRPFDETTYEETED
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  Blast E-value cutoff:
BDBM50461646
n/a
NameBDBM50461646
Synonyms:CHEBI:582124 | Myriocin
TypeSmall organic molecule
Emp. Form.C21H39NO6
Mol. Mass.401.5375
SMILESCCCCCCC(=O)CCCCCC\C=C\C[C@@H](O)[C@H](O)[C@@](N)(CO)C(O)=O |r|
Structure
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