| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-C |
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| Ligand | BDBM50248627 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1679277 (CHEMBL4029554) |
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| IC50 | 0.200000±n/a nM |
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| Citation |  Ono, K; Banno, H; Okaniwa, M; Hirayama, T; Iwamura, N; Hikichi, Y; Murai, S; Hasegawa, M; Hasegawa, Y; Yonemori, K; Hata, A; Aoyama, K; Cary, DR Design and synthesis of selective CDK8/19 dual inhibitors: Discovery of 4,5-dihydrothieno[3',4':3,4]benzo[1,2-d]isothiazole derivatives. Bioorg Med Chem25:2336-2350 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-C |
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| Name: | Cyclin-C |
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| Synonyms: | CCNC | CCNC_HUMAN | Cyclin C | SRB11 homolog | hSRB11 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 33244.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107900 |
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| Residue: | 283 |
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| Sequence: | MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQ
VIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRF
SYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIV
NDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQ
WKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
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| BDBM50248627 |
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| n/a |
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| Name | BDBM50248627 |
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| Synonyms: | CHEMBL4078454 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H16ClN3O2 |
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| Mol. Mass. | 341.792 |
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| SMILES | OC[C@H](Nc1cncc(n1)-c1ccc(O)c(Cl)c1)c1ccccc1 |r| |
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| Structure | 
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