Reaction Details |
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Target | Serine palmitoyltransferase 2 |
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Ligand | BDBM50461647 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1771688 (CHEMBL4223800) |
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IC50 | 1.2±n/a nM |
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Citation | Kojima, T; Asano, Y; Kurasawa, O; Hirata, Y; Iwamura, N; Wong, TT; Saito, B; Tanaka, Y; Arai, R; Yonemori, K; Miyamoto, Y; Sagiya, Y; Yaguchi, M; Shibata, S; Mizutani, A; Sano, O; Adachi, R; Satomi, Y; Hirayama, M; Aoyama, K; Hiura, Y; Kiba, A; Kitamura, S; Imamura, S Discovery of novel serine palmitoyltransferase inhibitors as cancer therapeutic agents. Bioorg Med Chem26:2452-2465 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine palmitoyltransferase 2 |
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Name: | Serine palmitoyltransferase 2 |
Synonyms: | KIAA0526 | LCB 2 | LCB2 | LCB2a | Long chain base biosynthesis protein 2 | Long chain base biosynthesis protein 2a | SPT 2 | SPTC2_HUMAN | SPTLC2 | Serine-palmitoyl-CoA transferase 2 |
Type: | PROTEIN |
Mol. Mass.: | 62932.15 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_660504 |
Residue: | 562 |
Sequence: | MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQNGGLYKRPFN
EAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFEN
FYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLG
FARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFA
TNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQ
PRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVV
EYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQII
TSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIG
AFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYS
RHRLVPLLDRPFDETTYEETED
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BDBM50461647 |
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n/a |
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Name | BDBM50461647 |
Synonyms: | CHEMBL4225462 |
Type | Small organic molecule |
Emp. Form. | C25H26F3N5O5 |
Mol. Mass. | 533.4996 |
SMILES | COc1cc(cnc1OC)C(=O)N1CCC(NC(=O)c2ccccc2OC(F)(F)F)c2c1cnn2C(C)C |
Structure |
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