| Reaction Details |
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 | Report a problem with these data |
| Target | Aspartate aminotransferase, cytoplasmic |
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| Ligand | BDBM50462486 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1775622 (CHEMBL4232614) |
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| IC50 | 36000±n/a nM |
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| Citation |  Anglin, J; Zavareh, RB; Sander, PN; Haldar, D; Mullarky, E; Cantley, LC; Kimmelman, AC; Lyssiotis, CA; Lairson, LL Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma. Bioorg Med Chem Lett28:2675-2678 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aspartate aminotransferase, cytoplasmic |
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| Name: | Aspartate aminotransferase, cytoplasmic |
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| Synonyms: | 2.6.1.1 | 2.6.1.3 | AATC_HUMAN | Aspartate aminotransferase, cytoplasmic | Cysteine aminotransferase, cytoplasmic | Cysteine transaminase, cytoplasmic | GOT1 | Glutamate oxaloacetate transaminase 1 | Transaminase A | cAspAT | cCAT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 46249.45 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_105469 |
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| Residue: | 413 |
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| Sequence: | MAPPSVFAEVPQAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWVLPVVKKVEQK
IANDNSLNHEYLPILGLAEFRSCASRLALGDDSPALKEKRVGGVQSLGGTGALRIGADFL
ARWYNGTNNKNTPVYVSSPTWENHNAVFSAAGFKDIRSYRYWDAEKRGLDLQGFLNDLEN
APEFSIVVLHACAHNPTGIDPTPEQWKQIASVMKHRFLFPFFDSAYQGFASGNLERDAWA
IRYFVSEGFEFFCAQSFSKNFGLYNERVGNLTVVGKEPESILQVLSQMEKIVRITWSNPP
AQGARIVASTLSNPELFEEWTGNVKTMADRILTMRSELRARLEALKTPGTWNHITDQIGM
FSFTGLNPKQVEYLVNEKHIYLLPSGRINVSGLTTKNLDYVATSIHEAVTKIQ
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| BDBM50462486 |
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| n/a |
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| Name | BDBM50462486 |
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| Synonyms: | CHEMBL4244220 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19F3N4O2 |
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| Mol. Mass. | 404.3857 |
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| SMILES | FC(F)(F)Oc1ccc(NC(=O)N2CCN(CC2)c2cccc3[nH]ccc23)cc1 |
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| Structure | 
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