| Reaction Details |
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 | Report a problem with these data |
| Target | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase |
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| Ligand | BDBM13216 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1776144 (CHEMBL4233136) |
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| IC50 | 6.0±n/a nM |
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| Citation |  Platzer, C; Najjar, A; Rohe, A; Erdmann, F; Sippl, W; Schmidt, M Identification of PKMYT1 inhibitors by screening the GSK published protein kinase inhibitor set I and II. Bioorg Med Chem26:4014-4024 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase |
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| Name: | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase |
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| Synonyms: | MYT1 | PKMYT1 | PMYT1_HUMAN | Tyrosine- and threonine-specific cdc2-inhibitory kinase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 54523.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_587209 |
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| Residue: | 499 |
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| Sequence: | MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGS
IPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGS
YGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEG
GILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIF
LGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVA
CNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLR
QPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCS
LLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSF
PSFEPRNLLSLFEDTLDPT
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| BDBM13216 |
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| n/a |
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| Name | BDBM13216 |
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| Synonyms: | BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide | N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | US10294227, Code Dasatinib | US20230348453, Compound A8 | cid_3062316 | med.21724, Compound Dasatinib |
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| Type | Small organic molecule |
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| Emp. Form. | C22H26ClN7O2S |
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| Mol. Mass. | 488.006 |
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| SMILES | Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1 |
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| Structure | 
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