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TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
LigandBDBM12255
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1776145 (CHEMBL4233137)
IC50 10000±n/a nM
Citation Platzer, C; Najjar, A; Rohe, A; Erdmann, F; Sippl, W; Schmidt, M Identification of PKMYT1 inhibitors by screening the GSK published protein kinase inhibitor set I and II. Bioorg Med Chem26:4014-4024 (2018) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Name:Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Synonyms:MYT1 | PKMYT1 | PMYT1_HUMAN | Tyrosine- and threonine-specific cdc2-inhibitory kinase
Type:PROTEIN
Mol. Mass.:54523.76
Organism:Homo sapiens (Human)
Description:ChEMBL_587209
Residue:499
Sequence:
MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGS
IPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGS
YGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEG
GILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIF
LGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVA
CNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLR
QPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCS
LLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSF
PSFEPRNLLSLFEDTLDPT
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  Blast E-value cutoff:
BDBM12255
n/a
NameBDBM12255
Synonyms:AZD0530 | CHEMBL217092 | Compound 33 | N-(5-chloro-2H-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(oxan-4-yloxy)quinazolin-4-amine | Saracatinib | med.21724, Compound 189
TypeSmall organic molecule
Emp. Form.C27H32ClN5O5
Mol. Mass.542.026
SMILESCN1CCN(CCOc2cc(OC3CCOCC3)c3c(Nc4c5OCOc5ccc4Cl)ncnc3c2)CC1
Structure
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