Reaction Details |
| Report a problem with these data |
Target | MAP kinase-activated protein kinase 3 |
---|
Ligand | BDBM50462709 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1776359 (CHEMBL4233351) |
---|
IC50 | >1000±n/a nM |
---|
Citation | Gao, H; Marhefka, C; Jacobs, MD; Cao, J; Bandarage, UK; Green, J ROCK inhibitors 2. Improving potency, selectivity and solubility through the application of rationally designed solubilizing groups. Bioorg Med Chem Lett28:2616-2621 (2018) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
MAP kinase-activated protein kinase 3 |
---|
Name: | MAP kinase-activated protein kinase 3 |
Synonyms: | 3pK | Chromosome 3p kinase | MAP kinase-activated protein kinase 3 (MAPKAP-K3) | MAPK-Activated Protein Kinase 3 (MK3) | MAPK-activated protein kinase 3 | MAPK3_HUMAN | MAPKAP kinase 3 | MAPKAPK-3 | MAPKAPK3 |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 42991.57 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant MAPKAPK3 was phosphorylated by incubation with active p38alpha before assays. |
Residue: | 382 |
Sequence: | MDGETAEEQGGPVPPPVAPGGPGLGGAPGGRREPKKYAVTDDYQLSKQVLGLGVNGKVLE
CFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMEC
MEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKD
AVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFP
PFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMN
HPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDYDQVKIKDLKTSNNR
LLNKRRKKQAGSSSASQGCNNQ
|
|
|
BDBM50462709 |
---|
n/a |
---|
Name | BDBM50462709 |
Synonyms: | CHEMBL4245507 |
Type | Small organic molecule |
Emp. Form. | C23H27N5O2S |
Mol. Mass. | 437.558 |
SMILES | O=C(Cc1cccc(OCCCN2CCNCC2)c1)Nc1nc(cs1)-c1ccncc1 |
Structure |
|