| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase MARK1 |
|---|
| Ligand | BDBM50462709 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1776360 (CHEMBL4233352) |
|---|
| IC50 | >1000±n/a nM |
|---|
| Citation |  Gao, H; Marhefka, C; Jacobs, MD; Cao, J; Bandarage, UK; Green, J ROCK inhibitors 2. Improving potency, selectivity and solubility through the application of rationally designed solubilizing groups. Bioorg Med Chem Lett28:2616-2621 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase MARK1 |
|---|
| Name: | Serine/threonine-protein kinase MARK1 |
|---|
| Synonyms: | KIAA1477 | MARK | MARK1 | MARK1_HUMAN |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 89034.85 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9P0L2 |
|---|
| Residue: | 795 |
|---|
| Sequence: | MSARTPLPTVNERDTENHTSVDGYTEPHIQPTKSSSRQNIPRCRNSITSATDEQPHIGNY
RLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIV
KLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVH
RDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDV
WSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRG
SLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDE
VMATYILLGRKPPEFEGGESLSSGNLCQRSRPSSDLNNSTLQSPAHLKVQRSISANQKQR
RFSDHAGPSIPPAVSYTKRPQANSVESEQKEEWDKDVARKLGSTTVGSKSEMTASPLVGP
ERKKSSTIPSNNVYSGGSMARRNTYVCERTTDRYVALQNGKDSSLTEMSVSSISSAGSSV
ASAVPSARPRHQKSMSTSGHPIKVTLPTIKDGSEAYRPGTTQRVPAASPSAHSISTATPD
RTRFPRGSSSRSTFHGEQLRERRSVAYNGPPASPSHETGAFAHARRGTSTGIISKITSKF
VRRDPSEGEASGRTDTSRSTSGEPKERDKEEGKDSKPRSLRFTWSMKTTSSMDPNDMMRE
IRKVLDANNCDYEQKERFLLFCVHGDARQDSLVQWEMEVCKLPRLSLNGVRFKRISGTSI
AFKNIASKIANELKL
|
|
|
|---|
| BDBM50462709 |
|---|
| n/a |
|---|
| Name | BDBM50462709 |
|---|
| Synonyms: | CHEMBL4245507 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H27N5O2S |
|---|
| Mol. Mass. | 437.558 |
|---|
| SMILES | O=C(Cc1cccc(OCCCN2CCNCC2)c1)Nc1nc(cs1)-c1ccncc1 |
|---|
| Structure | 
|
|---|
Search and Browse
