| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily KQT member 2 |
|---|
| Ligand | BDBM50463340 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1778027 (CHEMBL4235019) |
|---|
| EC50 | 2930±n/a nM |
|---|
| Citation |  Yang, S; Lu, D; Ouyang, P Design, synthesis and evaluation of novel N-phenylbutanamide derivatives as KCNQ openers for the treatment of epilepsy. Bioorg Med Chem Lett28:3004-3008 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Potassium voltage-gated channel subfamily KQT member 2 |
|---|
| Name: | Potassium voltage-gated channel subfamily KQT member 2 |
|---|
| Synonyms: | KCNQ (Kv7) potassium channel | KCNQ2 | KCNQ2_HUMAN | KQT-like 2 | Neuroblastoma-specific potassium channel subunit alpha KvLQT2 | Potassium voltage-gated channel subfamily KQT member 2 | Voltage-gated potassium channel subunit Kv7.2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 95883.20 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1457496 |
|---|
| Residue: | 872 |
|---|
| Sequence: | MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAG
GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEK
SSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASI
AVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGF
LCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLI
GVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTW
QYYERTVTVPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPSKGSP
CRGPLCGCCPGRSSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLEDSPSKV
PKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVDDKSCPCEFVTEDLTPGLKVSI
RAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPAIT
DKDRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEAYFG
AKEPEPAPPYHSPEDSREHVDRHGCIVKIVRSSSSTGQKNFSAPPAAPPVQCPPSTSWQP
QSHPRQGHGTSPVGDHGSLVRIPPPPAHERSLSAYGGGNRASMEFLRQEDTPGCRPPEGN
LRDSDTSISIPSVDHEELERSFSGFSISQSKENLDALNSCYAAVAPCAKVRPYIAEGESD
TDSDLCTPCGPPPRSATGEGPFGDVGWAGPRK
|
|
|
|---|
| BDBM50463340 |
|---|
| n/a |
|---|
| Name | BDBM50463340 |
|---|
| Synonyms: | CHEMBL4244025 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H27FN2OS |
|---|
| Mol. Mass. | 374.515 |
|---|
| SMILES | Cc1cc(cc(C)c1NC(=O)CC(C)(C)C)N1CCc2cc(F)sc2C1 |
|---|
| Structure | 
|
|---|
Search and Browse
