| Reaction Details |
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 | Report a problem with these data |
| Target | Thromboxane-A synthase |
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| Ligand | BDBM50024408 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_210453 |
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| IC50 | 50±n/a nM |
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| Citation |  Press, JB; Wright, WB; Chan, PS; Haug, MF; Marsico, JW; Tomcufcik, AS Thromboxane synthetase inhibitors and antihypertensive agents. 3. N-[(1H-imidazol-1-yl)alkyl]heteroaryl amides as potent enzyme inhibitors. J Med Chem30:1036-40 (1987) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Thromboxane-A synthase |
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| Name: | Thromboxane-A synthase |
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| Synonyms: | Cyp5 | Cyp5a1 | Cytochrome P450 5A1 | THAS_RAT | TXA synthase | TXS | Tbxas1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59971.80 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_209768 |
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| Residue: | 533 |
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| Sequence: | MEVLGLLKFEVSGTVVTVTLSVVLLALLKWYSTSAFSRLRKLGIRHPEPSPFVGNLMFFR
QGFWESHLELRERYGPLCGYYLGRRMYIVISDPDMIKEVLVENFSNFSNRMASGLEPKLI
ADSVLMLRDRRWEEVRGALMSAFSPEKLNEMTPLISQACELLLSHLKHSAASGDAFDIQR
CYCCFTTNVVASVAFGIEVNSQDAPEDPFVQHCQRVFAFSTPRPLLALILSFPSIMVPLA
RILPNKNRDELNGFFNTLIRNVIALRDKQTAEERRGDFLQMVLDAQRSMSSVGVEAFDMV
TEALSSAECMGDPPQRCHPTSTAKPLTVDEIAGQAFLFLIAGHEITTNTLSFITYLLATH
PECQERLLKEVDLFMEKHPAPEYCNLQEGLPYLDMVVAETLRMYPPAFRFTREAAQDCEV
LGQHIPAGSVLEIAVGALHHDPEHWPNPETFDPERFTAEARLQQKPFTYLPFGAGPRSCL
GVRLGLLVVKLTLLQVLHKFRFEACPETQVPLQLESKSALCPKNGVYVKIVSR
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| BDBM50024408 |
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| n/a |
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| Name | BDBM50024408 |
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| Synonyms: | 5-Chloro-1H-indole-2-carboxylic acid (3-imidazol-1-yl-butyl)-amide | CHEMBL406693 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H17ClN4O |
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| Mol. Mass. | 316.785 |
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| SMILES | CC(CCNC(=O)c1cc2cc(Cl)ccc2[nH]1)n1ccnc1 |
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| Structure | 
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