| Reaction Details |
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 | Report a problem with these data |
| Target | 2-5A-dependent ribonuclease |
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| Ligand | BDBM50025006 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_164143 |
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| IC50 | >40000±n/a nM |
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| Citation |  Lesiak, K; Torrence, PF Synthesis and biological activities of oligo(8-bromoadenylates) as analogues of 5'-O-triphosphoadenylyl(2'----5')adenylyl(2'----5')adenosine. J Med Chem29:1015-22 (1986) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| 2-5A-dependent ribonuclease |
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| Name: | 2-5A-dependent ribonuclease |
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| Synonyms: | 2-5A-dependent RNase | 2-5A-dependent ribonuclease | RN5A_MOUSE | RNase L | Ribonuclease 4 | Ribonuclease L | Rnasel | Rns4 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 83274.00 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_195099 |
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| Residue: | 735 |
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| Sequence: | METPDYNTPQGGTPSAGSQRTVVEDDSSLIKAVQKGDVVRVQQLLEKGADANACEDTWGW
TPLHNAVQAGRVDIVNLLLSHGADPHRRKKNGATPFIIAGIQGDVKLLEILLSCGADVNE
CDENGFTAFMEAAERGNAEALRFLFAKGANVNLRRQTTKDKRRLKQGGATALMSAAEKGH
LEVLRILLNDMKAEVDARDNMGRNALIRTLLNWDCENVEEITSILIQHGADVNVRGERGK
TPLIAAVERKHTGLVQMLLSREGINIDARDNEGKTALLIAVDKQLKEIVQLLLEKGADKC
DDLVWIARRNHDYHLVKLLLPYVANPDTDPPAGDWSPHSSRWGTALKSLHSMTRPMIGKL
KIFIHDDYKIAGTSEGAVYLGIYDNREVAVKVFRENSPRGCKEVSCLRDCGDHSNLVAFY
GREDDKGCLYVCVSLCEWTLEEFLRLPREEPVENGEDKFAHSILLSIFEGVQKLHLHGYS
HQDLQPQNILIDSKKAVRLADFDQSIRWMGESQMVRRDLEDLGRLVLYVVMKGEIPFETL
KTQNDEVLLTMSPDEETKDLIHCLFSPGENVKNCLVDLLGHPFFWTWENRYRTLRNVGNE
SDIKVRKCKSDLLRLLQHQTLEPPRSFDQWTSKIDKNVMDEMNHFYEKRKKNPYQDTVGD
LLKFIRNIGEHINEEKKRGMKEILGDPSRYFQETFPDLVIYIYKKLKETEYRKHFPQPPP
RLSVPEAVGPGGIQS
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| BDBM50025006 |
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| n/a |
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| Name | BDBM50025006 |
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| Synonyms: | (br8A)2'p5'(br8A)2'p5'(br8A)2'p5'(br8A) | CHEMBL3143468 |
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| Type | Small organic molecule |
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| Emp. Form. | C50H57Br5N25O31P5 |
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| Mol. Mass. | 2058.525 |
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| SMILES | Nc1ncnc2n([C@H]3O[C@@H](COP(O)(=O)O[C@H]4[C@@H](O)[C@H](COP(O)(=O)O[C@H]5[C@@H](O)[C@H](COP(O)(=O)O[C@H]6[C@@H](O)[C@H](COP(O)(=O)O[C@H]7[C@@H](O)[C@H](COP(O)(O)=O)O[C@@H]7n7c(Br)nc8c(N)ncnc78)O[C@@H]6n6c(Br)nc7c(N)ncnc67)O[C@@H]5n5c(Br)nc6c(N)ncnc56)O[C@@H]4n4c(Br)nc5c(N)ncnc45)[C@H](O)[C@@H]3O)c(Br)nc12 |r| |
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| Structure | 
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