Compile Data Set for Download or QSAR

Found 47 hits with Last Name = 'torrence' and Initial = 'pf'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Thymidylate synthase (Lactobacillus casei)	BDBM50022238 ((R)-5-Fluoro-1-((4S,5R)-4-hydroxy-5-methylphosphat...) Show SMILES O[C@H]1C[C@@H](O[C@@H]1COP(O)(O)=O)n1cc(F)c(=O)[nH]c1=O Show InChI InChI=1S/C9H12FN2O8P/c10-4-2-12(9(15)11-8(4)14)7-1-5(13)6(20-7)3-19-21(16,17)18/h2,5-7,13H,1,3H2,(H,11,14,15)(H2,16,17,18)/t5-,6+,7+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Competitive inhibition of thymidylate synthase purified from methotrexate-resistant Lactobacillus casei using 2'-deoxy[5-3H]uridine 5'-phosphate by r...				J Med Chem 22: 1137-9 (1979) BindingDB Entry DOI: 10.7270/Q2XK8H3F
					More data for this Ligand-Target Pair				3D Structure (crystal)
Thymidylate synthase (Lactobacillus casei)	BDBM50010241 (CHEMBL1234672) Show SMILES O[C@H]1C[C@@H](O[C@@H]1COP(O)(O)=O)n1cc([N+]([O-])=O)c(=O)[nH]c1=O |r| Show InChI InChI=1S/C9H12N3O10P/c13-5-1-7(22-6(5)3-21-23(18,19)20)11-2-4(12(16)17)8(14)10-9(11)15/h2,5-7,13H,1,3H2,(H,10,14,15)(H2,18,19,20)/t5-,6+,7+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PubMed	29	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Competitive inhibition of thymidylate synthase purified from methotrexate-resistant Lactobacillus casei using 2'-deoxy[5-3H]uridine 5'-phosphate by r...				J Med Chem 22: 1137-9 (1979) BindingDB Entry DOI: 10.7270/Q2XK8H3F
					More data for this Ligand-Target Pair
Thymidylate synthase (Lactobacillus casei)	BDBM50010236 (CHEMBL3144200) Show SMILES O[C@H]1C[C@@H](O[C@@H]1COP(O)(O)=O)n1cc(c(=O)[nH]c1=O)C(F)(F)F |r| Show InChI InChI=1S/C10H12F3N2O8P/c11-10(12,13)4-2-15(9(18)14-8(4)17)7-1-5(16)6(23-7)3-22-24(19,20)21/h2,5-7,16H,1,3H2,(H,14,17,18)(H2,19,20,21)/t5-,6+,7+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	39	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Competitive inhibition of thymidylate synthase purified from methotrexate-resistant Lactobacillus casei using 2'-deoxy[5-3H]uridine 5'-phosphate by r...				J Med Chem 22: 1137-9 (1979) BindingDB Entry DOI: 10.7270/Q2XK8H3F
					More data for this Ligand-Target Pair
Thymidylate synthase (Lactobacillus casei)	BDBM50000038 (CHEMBL3228321) Show SMILES O[C@H]1C[C@@H](O[C@@H]1COP(O)(O)=O)n1cc(S)c(=O)[nH]c1=O |r| Show InChI InChI=1S/C9H13N2O8PS/c12-4-1-7(19-5(4)3-18-20(15,16)17)11-2-6(21)8(13)10-9(11)14/h2,4-5,7,12,21H,1,3H2,(H,10,13,14)(H2,15,16,17)/t4-,5+,7+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Competitive inhibition of thymidylate synthase purified from methotrexate-resistant Lactobacillus casei using 2'-deoxy[5-3H]uridine 5'-phosphate by r...				J Med Chem 22: 1137-9 (1979) BindingDB Entry DOI: 10.7270/Q2XK8H3F
					More data for this Ligand-Target Pair
Thymidylate synthase (Lactobacillus casei)	BDBM50010239 (CHEMBL1236538) Show SMILES O[C@H]1C[C@@H](O[C@@H]1COP(O)(O)=O)n1cc(Cl)c(=O)[nH]c1=O |r| Show InChI InChI=1S/C9H12ClN2O8P/c10-4-2-12(9(15)11-8(4)14)7-1-5(13)6(20-7)3-19-21(16,17)18/h2,5-7,13H,1,3H2,(H,11,14,15)(H2,16,17,18)/t5-,6+,7+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PubMed	190	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Competitive inhibition of thymidylate synthase purified from methotrexate-resistant Lactobacillus casei using 2'-deoxy[5-3H]uridine 5'-phosphate by r...				J Med Chem 22: 1137-9 (1979) BindingDB Entry DOI: 10.7270/Q2XK8H3F
					More data for this Ligand-Target Pair
Thymidylate synthase (Lactobacillus casei)	BDBM50010240 (CHEMBL3246102) Show SMILES O[C@H]1C[C@@H](O[C@@H]1COP(O)(O)=O)n1cc(C#N)c(=O)[nH]c1=O |r| Show InChI InChI=1S/C10H12N3O8P/c11-2-5-3-13(10(16)12-9(5)15)8-1-6(14)7(21-8)4-20-22(17,18)19/h3,6-8,14H,1,4H2,(H,12,15,16)(H2,17,18,19)/t6-,7+,8+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Competitive inhibition of thymidylate synthase purified from methotrexate-resistant Lactobacillus casei using 2'-deoxy[5-3H]uridine 5'-phosphate by r...				J Med Chem 22: 1137-9 (1979) BindingDB Entry DOI: 10.7270/Q2XK8H3F
					More data for this Ligand-Target Pair
Thymidylate synthase (Lactobacillus casei)	BDBM50010238 (CHEMBL1160593) Show SMILES O[C@H]1C[C@@H](O[C@@H]1COP(O)(O)=O)n1cc(Br)c(=O)[nH]c1=O |r| Show InChI InChI=1S/C9H12BrN2O8P/c10-4-2-12(9(15)11-8(4)14)7-1-5(13)6(20-7)3-19-21(16,17)18/h2,5-7,13H,1,3H2,(H,11,14,15)(H2,16,17,18)/t5-,6+,7+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PubMed	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Competitive inhibition of thymidylate synthase purified from methotrexate-resistant Lactobacillus casei using 2'-deoxy[5-3H]uridine 5'-phosphate by r...				J Med Chem 22: 1137-9 (1979) BindingDB Entry DOI: 10.7270/Q2XK8H3F
					More data for this Ligand-Target Pair
Thymidylate synthase (Lactobacillus casei)	BDBM50010242 (CHEMBL1160594) Show SMILES O[C@H]1C[C@@H](O[C@@H]1COP(O)(O)=O)n1cc(I)c(=O)[nH]c1=O |r| Show InChI InChI=1S/C9H12IN2O8P/c10-4-2-12(9(15)11-8(4)14)7-1-5(13)6(20-7)3-19-21(16,17)18/h2,5-7,13H,1,3H2,(H,11,14,15)(H2,16,17,18)/t5-,6+,7+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Competitive inhibition of thymidylate synthase purified from methotrexate-resistant Lactobacillus casei using 2'-deoxy[5-3H]uridine 5'-phosphate by r...				J Med Chem 22: 1137-9 (1979) BindingDB Entry DOI: 10.7270/Q2XK8H3F
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Homo sapiens (Human))	BDBM50085553 (CHEMBL214603 | Oligoadenylate analogue) Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]5n5cnc6c(N)ncnc56)O[C@H]4n4cnc5c(N)ncnc45)[C@@H](O)[C@H]3O)c2n1 Show InChI InChI=1S/C31H42N15O25P5/c1-10-42-25(34)16-28(43-10)46(9-41-16)29-20(50)17(47)11(65-29)2-62-73(54,55)68-21-18(48)12(66-30(21)44-7-39-14-23(32)35-5-37-26(14)44)3-63-74(56,57)69-22-19(49)13(4-64-75(58,59)71-76(60,61)70-72(51,52)53)67-31(22)45-8-40-15-24(33)36-6-38-27(15)45/h5-9,11-13,17-22,29-31,47-50H,2-4H2,1H3,(H,54,55)(H,56,57)(H,58,59)(H,60,61)(H2,32,35,37)(H2,33,36,38)(H2,34,42,43)(H2,51,52,53)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.720	n/a	n/a	n/a	n/a	n/a	n/a
Gifu University Curated by ChEMBL					Assay Description Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease L				Bioorg Med Chem Lett 10: 329-31 (2000) BindingDB Entry DOI: 10.7270/Q2TM79B4
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Mus musculus)	BDBM50421415 (CHEMBL414948) Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@](O)(=O)O[C@@H]2[C@H](O)[C@@H](CO[P@](O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C30H38N15O19P3/c31-22-13-25(37-4-34-22)43(7-40-13)28-19(49)16(46)10(60-28)2-58-66(53,54)64-21-18(48)12(62-30(21)45-9-42-15-24(33)36-6-39-27(15)45)3-59-67(55,56)63-20-17(47)11(1-57-65(50,51)52)61-29(20)44-8-41-14-23(32)35-5-38-26(14)44/h4-12,16-21,28-30,46-49H,1-3H2,(H,53,54)(H,55,56)(H2,31,34,37)(H2,32,35,38)(H2,33,36,39)(H2,50,51,52)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/m1/s1	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	0.950	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in mouse L cells				J Med Chem 28: 1376-80 (1985) BindingDB Entry DOI: 10.7270/Q26W9BNH
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Homo sapiens (Human))	BDBM50421415 (CHEMBL414948) Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@](O)(=O)O[C@@H]2[C@H](O)[C@@H](CO[P@](O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C30H38N15O19P3/c31-22-13-25(37-4-34-22)43(7-40-13)28-19(49)16(46)10(60-28)2-58-66(53,54)64-21-18(48)12(62-30(21)45-9-42-15-24(33)36-6-39-27(15)45)3-59-67(55,56)63-20-17(47)11(1-57-65(50,51)52)61-29(20)44-8-41-14-23(32)35-5-38-26(14)44/h4-12,16-21,28-30,46-49H,1-3H2,(H,53,54)(H,55,56)(H2,31,34,37)(H2,32,35,38)(H2,33,36,39)(H2,50,51,52)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in human Daudi lymphoblastoid cells				J Med Chem 28: 1376-80 (1985) BindingDB Entry DOI: 10.7270/Q26W9BNH
					More data for this Ligand-Target Pair				3D Structure (crystal)
2-5A-dependent ribonuclease (Mus musculus)	BDBM50025002 (CHEMBL404038 | ppp'A2'p5'A2'p5'A | ppp5'A2'p5'A2'p...) Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O Show InChI InChI=1S/C30H40N15O25P5/c31-22-13-25(37-4-34-22)43(7-40-13)28-19(49)16(46)10(64-28)1-61-72(53,54)67-20-17(47)11(65-29(20)44-8-41-14-23(32)35-5-38-26(14)44)2-62-73(55,56)68-21-18(48)12(3-63-74(57,58)70-75(59,60)69-71(50,51)52)66-30(21)45-9-42-15-24(33)36-6-39-27(15)45/h4-12,16-21,28-30,46-49H,1-3H2,(H,53,54)(H,55,56)(H,57,58)(H,59,60)(H2,31,34,37)(H2,32,35,38)(H2,33,36,39)(H2,50,51,52)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/m1/s1	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extracts				J Med Chem 29: 1015-22 (1986) BindingDB Entry DOI: 10.7270/Q2SX6C6K
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Homo sapiens (Human))	BDBM50085558 (CHEMBL402676 | Oligoadenylate analogue) Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]5n5cnc6c(N)ncnc56)O[C@H]4n4cnc5c(N)ncnc45)[C@@H](O)[C@H]3O)c2n1 Show InChI InChI=1S/C31H40N15O19P3/c1-10-42-25(34)16-28(43-10)46(9-41-16)29-20(50)17(47)11(61-29)3-59-67(54,55)65-22-19(49)13(63-31(22)45-8-40-15-24(33)36-6-38-27(15)45)4-60-68(56,57)64-21-18(48)12(2-58-66(51,52)53)62-30(21)44-7-39-14-23(32)35-5-37-26(14)44/h5-9,11-13,17-22,29-31,47-50H,2-4H2,1H3,(H,54,55)(H,56,57)(H2,32,35,37)(H2,33,36,38)(H2,34,42,43)(H2,51,52,53)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
Gifu University Curated by ChEMBL					Assay Description Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of poly (U) 3'[32P]p5'C3'p				Bioorg Med Chem Lett 10: 329-31 (2000) BindingDB Entry DOI: 10.7270/Q2TM79B4
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Homo sapiens (Human))	BDBM50085554 (5'-O-MONOPHOSPHORYLADENYLYL(2'->5')ADENYLYL(2'->5'...) Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O Show InChI InChI=1S/C30H38N15O19P3/c31-22-13-25(37-4-34-22)43(7-40-13)28-19(49)16(46)10(60-28)2-58-66(53,54)64-21-18(48)12(62-30(21)45-9-42-15-24(33)36-6-39-27(15)45)3-59-67(55,56)63-20-17(47)11(1-57-65(50,51)52)61-29(20)44-8-41-14-23(32)35-5-38-26(14)44/h4-12,16-21,28-30,46-49H,1-3H2,(H,53,54)(H,55,56)(H2,31,34,37)(H2,32,35,38)(H2,33,36,39)(H2,50,51,52)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Similars	MMDB PubMed	n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a	n/a
Gifu University Curated by ChEMBL					Assay Description Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of [32P]-pC11U2C7				Bioorg Med Chem Lett 10: 329-31 (2000) BindingDB Entry DOI: 10.7270/Q2TM79B4
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Homo sapiens (Human))	BDBM50421415 (CHEMBL414948) Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@](O)(=O)O[C@@H]2[C@H](O)[C@@H](CO[P@](O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C30H38N15O19P3/c31-22-13-25(37-4-34-22)43(7-40-13)28-19(49)16(46)10(60-28)2-58-66(53,54)64-21-18(48)12(62-30(21)45-9-42-15-24(33)36-6-39-27(15)45)3-59-67(55,56)63-20-17(47)11(1-57-65(50,51)52)61-29(20)44-8-41-14-23(32)35-5-38-26(14)44/h4-12,16-21,28-30,46-49H,1-3H2,(H,53,54)(H,55,56)(H2,31,34,37)(H2,32,35,38)(H2,33,36,39)(H2,50,51,52)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes and Digestive antd Kidney Diseases Curated by ChEMBL					Assay Description Displacement of the probe bound to Ribonuclease L by compound in radiobinding assay was evaluated				Bioorg Med Chem Lett 10: 1357-60 (2000) BindingDB Entry DOI: 10.7270/Q2TT4Q67
					More data for this Ligand-Target Pair				3D Structure (crystal)
2-5A-dependent ribonuclease (Homo sapiens (Human))	BDBM50421415 (CHEMBL414948) Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@](O)(=O)O[C@@H]2[C@H](O)[C@@H](CO[P@](O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C30H38N15O19P3/c31-22-13-25(37-4-34-22)43(7-40-13)28-19(49)16(46)10(60-28)2-58-66(53,54)64-21-18(48)12(62-30(21)45-9-42-15-24(33)36-6-39-27(15)45)3-59-67(55,56)63-20-17(47)11(1-57-65(50,51)52)61-29(20)44-8-41-14-23(32)35-5-38-26(14)44/h4-12,16-21,28-30,46-49H,1-3H2,(H,53,54)(H,55,56)(H2,31,34,37)(H2,32,35,38)(H2,33,36,39)(H2,50,51,52)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in rabbit reticulocytes				J Med Chem 28: 1376-80 (1985) BindingDB Entry DOI: 10.7270/Q26W9BNH
					More data for this Ligand-Target Pair				3D Structure (crystal)
2-5A-dependent ribonuclease (Homo sapiens (Human))	BDBM50085556 (CHEMBL405496 | Oligoadenylate analogue) Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3OP(O)(=O)OC[C@H]3O[C@H]([C@H](OP(O)(=O)OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)n4cnc5c(N)ncnc45)[C@@H]3O)n3cnc4c(N)ncnc34)c2n1 Show InChI InChI=1S/C31H42N15O25P5/c1-10-42-25(34)16-28(43-10)46(9-41-16)31-22(19(49)13(67-31)4-64-75(58,59)71-76(60,61)70-72(51,52)53)69-74(56,57)63-3-12-18(48)21(30(66-12)45-8-40-15-24(33)36-6-38-27(15)45)68-73(54,55)62-2-11-17(47)20(50)29(65-11)44-7-39-14-23(32)35-5-37-26(14)44/h5-9,11-13,17-22,29-31,47-50H,2-4H2,1H3,(H,54,55)(H,56,57)(H,58,59)(H,60,61)(H2,32,35,37)(H2,33,36,38)(H2,34,42,43)(H2,51,52,53)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Gifu University Curated by ChEMBL					Assay Description Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease L				Bioorg Med Chem Lett 10: 329-31 (2000) BindingDB Entry DOI: 10.7270/Q2TM79B4
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Mus musculus)	BDBM50025005 (CHEMBL3143469 | pp5'(br8A)2'p5'(br8A)2'p5'(br8A)) Show SMILES Nc1ncnc2n([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]5n5c(Br)nc6c(N)ncnc56)O[C@H]4n4c(Br)nc5c(N)ncnc45)[C@@H](O)[C@H]3O)c(Br)nc12 |r| Show InChI InChI=1S/C30H36Br3N15O19P4/c31-28-43-17-20(34)37-7-40-23(17)46(28)16-3-12(49)15(64-16)6-61-70(55,56)66-14-1-10(62-27(14)48-25-19(45-30(48)33)22(36)39-9-42-25)4-59-69(53,54)65-13-2-11(5-60-71(57,58)67-68(50,51)52)63-26(13)47-24-18(44-29(47)32)21(35)38-8-41-24/h7-16,26-27,49H,1-6H2,(H,53,54)(H,55,56)(H,57,58)(H2,34,37,40)(H2,35,38,41)(H2,36,39,42)(H2,50,51,52)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extracts				J Med Chem 29: 1015-22 (1986) BindingDB Entry DOI: 10.7270/Q2SX6C6K
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Homo sapiens (Human))	BDBM50085555 (CHEMBL384725 | Oligoadenylate analogue) Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3OP(O)(=O)OC[C@H]3O[C@H]([C@H](OP(O)(=O)OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)n4cnc5c(N)ncnc45)[C@@H]3O)n3cnc4c(N)ncnc34)c2n1 Show InChI InChI=1S/C31H40N15O19P3/c1-10-42-25(34)16-28(43-10)46(9-41-16)31-22(18(48)12(62-31)2-58-66(51,52)53)65-68(56,57)60-4-13-19(49)21(30(63-13)45-8-40-15-24(33)36-6-38-27(15)45)64-67(54,55)59-3-11-17(47)20(50)29(61-11)44-7-39-14-23(32)35-5-37-26(14)44/h5-9,11-13,17-22,29-31,47-50H,2-4H2,1H3,(H,54,55)(H,56,57)(H2,32,35,37)(H2,33,36,38)(H2,34,42,43)(H2,51,52,53)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
Gifu University Curated by ChEMBL					Assay Description Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of poly (U) 3'[32P]p5'C3'p				Bioorg Med Chem Lett 10: 329-31 (2000) BindingDB Entry DOI: 10.7270/Q2TM79B4
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Homo sapiens (Human))	BDBM50085559 (CHEMBL410213 | Oligoadenylate analogue) Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]5n5cnc6c(N)nc(C)nc56)O[C@H]4n4cnc5c(N)nc(C)nc45)[C@@H](O)[C@H]3O)c2n1 Show InChI InChI=1S/C33H46N15O25P5/c1-10-40-25(34)16-28(43-10)46(7-37-16)31-22(52)19(49)13(67-31)4-64-75(56,57)70-23-20(50)14(68-32(23)47-8-38-17-26(35)41-11(2)44-29(17)47)5-65-76(58,59)71-24-21(51)15(6-66-77(60,61)73-78(62,63)72-74(53,54)55)69-33(24)48-9-39-18-27(36)42-12(3)45-30(18)48/h7-9,13-15,19-24,31-33,49-52H,4-6H2,1-3H3,(H,56,57)(H,58,59)(H,60,61)(H,62,63)(H2,34,40,43)(H2,35,41,44)(H2,36,42,45)(H2,53,54,55)/t13-,14-,15-,19-,20-,21-,22-,23-,24-,31-,32-,33-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	105	n/a	n/a	n/a	n/a	n/a	n/a
Gifu University Curated by ChEMBL					Assay Description Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease L				Bioorg Med Chem Lett 10: 329-31 (2000) BindingDB Entry DOI: 10.7270/Q2TM79B4
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Mus musculus)	BDBM50025001 (CHEMBL3143411 | pp5'(br8A)2'p5'(br8A)2'p5'(br8A)2'...) Show SMILES Nc1ncnc2n([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]5n5c(Br)nc6c(N)ncnc56)O[C@H]4n4c(Br)nc5c(N)ncnc45)[C@@H](O)[C@H]3O)c(Br)nc12 |r| Show InChI InChI=1S/C50H59Br5N25O32P7/c51-46-71-27-32(56)61-11-66-37(27)76(46)26-5-20(81)25(106-26)10-101-117(91,92)110-24-3-18(104-45(24)80-41-31(75-50(80)55)36(60)65-15-70-41)8-99-115(87,88)108-22-1-16(102-43(22)78-39-29(73-48(78)53)34(58)63-13-68-39)6-97-114(85,86)107-21-2-17(103-42(21)77-38-28(72-47(77)52)33(57)62-12-67-38)7-98-116(89,90)109-23-4-19(9-100-118(93,94)112-119(95,96)111-113(82,83)84)105-44(23)79-40-30(74-49(79)54)35(59)64-14-69-40/h11-26,42-45,81H,1-10H2,(H,85,86)(H,87,88)(H,89,90)(H,91,92)(H,93,94)(H,95,96)(H2,56,61,66)(H2,57,62,67)(H2,58,63,68)(H2,59,64,69)(H2,60,65,70)(H2,82,83,84)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extracts				J Med Chem 29: 1015-22 (1986) BindingDB Entry DOI: 10.7270/Q2SX6C6K
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Homo sapiens (Human))	BDBM50021104 ((2'-5'(pAris)3) Show SMILES Nc1ncnc2n(cnc12)C1CC(COP([O-])(=O)OC2C(O)C(COP([O-])(=O)OC3C(O)C(COP([O-])([O-])=O)CC3n3cnc4c(N)ncnc34)CC2n2cnc3c(N)ncnc23)C(O)C1O Show InChI InChI=1S/C33H44N15O16P3/c34-28-19-31(40-7-37-28)46(10-43-19)16-1-13(22(49)25(16)52)5-61-66(56,57)64-27-18(48-12-45-21-30(36)39-9-42-33(21)48)3-15(24(27)51)6-62-67(58,59)63-26-17(2-14(23(26)50)4-60-65(53,54)55)47-11-44-20-29(35)38-8-41-32(20)47/h7-18,22-27,49-52H,1-6H2,(H,56,57)(H,58,59)(H2,34,37,40)(H2,35,38,41)(H2,36,39,42)(H2,53,54,55)/p-4	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in human Daudi lymphoblastoid cells				J Med Chem 28: 1376-80 (1985) BindingDB Entry DOI: 10.7270/Q26W9BNH
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Mus musculus)	BDBM50025000 (CHEMBL3143409 | ppp5'(br8A)2'p5'(br8A)2'p5'(br8A)) Show SMILES Nc1ncnc2n([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)O[C@@H]6[C@H](O)[C@@H](COP(O)(=O)O[C@@H]7[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]7n7c(Br)nc8c(N)ncnc78)O[C@H]6n6c(Br)nc7c(N)ncnc67)O[C@H]5n5c(Br)nc6c(N)ncnc56)O[C@H]4n4c(Br)nc5c(N)ncnc45)[C@@H](O)[C@H]3O)c(Br)nc12 |r| Show InChI InChI=1S/C30H37Br3N15O22P5/c31-28-43-17-20(34)37-7-40-23(17)46(28)16-3-12(49)15(66-16)6-63-73(55,56)68-14-1-10(64-27(14)48-25-19(45-30(48)33)22(36)39-9-42-25)4-61-72(53,54)67-13-2-11(5-62-74(57,58)70-75(59,60)69-71(50,51)52)65-26(13)47-24-18(44-29(47)32)21(35)38-8-41-24/h7-16,26-27,49H,1-6H2,(H,53,54)(H,55,56)(H,57,58)(H,59,60)(H2,34,37,40)(H2,35,38,41)(H2,36,39,42)(H2,50,51,52)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extracts				J Med Chem 29: 1015-22 (1986) BindingDB Entry DOI: 10.7270/Q2SX6C6K
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Mus musculus)	BDBM50021104 ((2'-5'(pAris)3) Show SMILES Nc1ncnc2n(cnc12)C1CC(COP([O-])(=O)OC2C(O)C(COP([O-])(=O)OC3C(O)C(COP([O-])([O-])=O)CC3n3cnc4c(N)ncnc34)CC2n2cnc3c(N)ncnc23)C(O)C1O Show InChI InChI=1S/C33H44N15O16P3/c34-28-19-31(40-7-37-28)46(10-43-19)16-1-13(22(49)25(16)52)5-61-66(56,57)64-27-18(48-12-45-21-30(36)39-9-42-33(21)48)3-15(24(27)51)6-62-67(58,59)63-26-17(2-14(23(26)50)4-60-65(53,54)55)47-11-44-20-29(35)38-8-41-32(20)47/h7-18,22-27,49-52H,1-6H2,(H,56,57)(H,58,59)(H2,34,37,40)(H2,35,38,41)(H2,36,39,42)(H2,53,54,55)/p-4	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in mouse L cells				J Med Chem 28: 1376-80 (1985) BindingDB Entry DOI: 10.7270/Q26W9BNH
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Mus musculus)	BDBM50024997 (CHEMBL3143462 | p5'(br8A)2'p5'(br8A)2'p5'(br8A)) Show SMILES Nc1ncnc2n([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)O[C@@H]6[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]6n6c(Br)nc7c(N)ncnc67)O[C@H]5n5c(Br)nc6c(N)ncnc56)O[C@H]4n4c(Br)nc5c(N)ncnc45)[C@@H](O)[C@H]3O)c(Br)nc12 |r| Show InChI InChI=1S/C30H35Br3N15O16P3/c31-28-43-17-20(34)37-7-40-23(17)46(28)16-3-12(49)15(62-16)6-59-67(55,56)64-14-2-11(61-27(14)48-25-19(45-30(48)33)22(36)39-9-42-25)5-58-66(53,54)63-13-1-10(4-57-65(50,51)52)60-26(13)47-24-18(44-29(47)32)21(35)38-8-41-24/h7-16,26-27,49H,1-6H2,(H,53,54)(H,55,56)(H2,34,37,40)(H2,35,38,41)(H2,36,39,42)(H2,50,51,52)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extracts				J Med Chem 29: 1015-22 (1986) BindingDB Entry DOI: 10.7270/Q2SX6C6K
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Mus musculus)	BDBM50025003 ((br8A)2'p5'(br8A)2'p5'(br8A) | CHEMBL3143413) Show SMILES Nc1ncnc2n([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]5n5c(Br)nc6c(N)ncnc56)O[C@H]4n4c(Br)nc5c(N)ncnc45)[C@@H](O)[C@H]3O)c(Br)nc12 |r| Show InChI InChI=1S/C30H34Br3N15O13P2/c31-28-43-17-20(34)37-7-40-23(17)46(28)16-3-12(50)15(59-16)6-56-63(53,54)61-14-2-11(58-27(14)48-25-19(45-30(48)33)22(36)39-9-42-25)5-55-62(51,52)60-13-1-10(4-49)57-26(13)47-24-18(44-29(47)32)21(35)38-8-41-24/h7-16,26-27,49-50H,1-6H2,(H,51,52)(H,53,54)(H2,34,37,40)(H2,35,38,41)(H2,36,39,42)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extracts				J Med Chem 29: 1015-22 (1986) BindingDB Entry DOI: 10.7270/Q2SX6C6K
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Homo sapiens (Human))	BDBM50085557 (CHEMBL407239 | Oligoadenylate analogue) Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]5n5cnc6c(N)nc(C)nc56)O[C@H]4n4cnc5c(N)nc(C)nc45)[C@@H](O)[C@H]3O)c2n1 Show InChI InChI=1S/C33H44N15O19P3/c1-10-40-25(34)16-28(43-10)46(7-37-16)31-22(52)19(49)13(63-31)5-61-69(56,57)67-24-21(51)15(65-33(24)48-9-39-18-27(36)42-12(3)45-30(18)48)6-62-70(58,59)66-23-20(50)14(4-60-68(53,54)55)64-32(23)47-8-38-17-26(35)41-11(2)44-29(17)47/h7-9,13-15,19-24,31-33,49-52H,4-6H2,1-3H3,(H,56,57)(H,58,59)(H2,34,40,43)(H2,35,41,44)(H2,36,42,45)(H2,53,54,55)/t13-,14-,15-,19-,20-,21-,22-,23-,24-,31-,32-,33-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.06E+3	n/a	n/a	n/a	n/a	n/a	n/a
Gifu University Curated by ChEMBL					Assay Description Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease L				Bioorg Med Chem Lett 10: 329-31 (2000) BindingDB Entry DOI: 10.7270/Q2TM79B4
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Homo sapiens (Human))	BDBM50021104 ((2'-5'(pAris)3) Show SMILES Nc1ncnc2n(cnc12)C1CC(COP([O-])(=O)OC2C(O)C(COP([O-])(=O)OC3C(O)C(COP([O-])([O-])=O)CC3n3cnc4c(N)ncnc34)CC2n2cnc3c(N)ncnc23)C(O)C1O Show InChI InChI=1S/C33H44N15O16P3/c34-28-19-31(40-7-37-28)46(10-43-19)16-1-13(22(49)25(16)52)5-61-66(56,57)64-27-18(48-12-45-21-30(36)39-9-42-33(21)48)3-15(24(27)51)6-62-67(58,59)63-26-17(2-14(23(26)50)4-60-65(53,54)55)47-11-44-20-29(35)38-8-41-32(20)47/h7-18,22-27,49-52H,1-6H2,(H,56,57)(H,58,59)(H2,34,37,40)(H2,35,38,41)(H2,36,39,42)(H2,53,54,55)/p-4	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in rabbit reticulocytes				J Med Chem 28: 1376-80 (1985) BindingDB Entry DOI: 10.7270/Q26W9BNH
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Mus musculus)	BDBM50025006 ((br8A)2'p5'(br8A)2'p5'(br8A)2'p5'(br8A) | CHEMBL31...) Show SMILES Nc1ncnc2n([C@H]3O[C@@H](COP(O)(=O)O[C@H]4[C@@H](O)[C@H](COP(O)(=O)O[C@H]5[C@@H](O)[C@H](COP(O)(=O)O[C@H]6[C@@H](O)[C@H](COP(O)(=O)O[C@H]7[C@@H](O)[C@H](COP(O)(O)=O)O[C@@H]7n7c(Br)nc8c(N)ncnc78)O[C@@H]6n6c(Br)nc7c(N)ncnc67)O[C@@H]5n5c(Br)nc6c(N)ncnc56)O[C@@H]4n4c(Br)nc5c(N)ncnc45)[C@H](O)[C@@H]3O)c(Br)nc12 |r| Show InChI InChI=1S/C40H45Br4N20O18P3/c41-37-57-22-26(45)49-9-53-30(22)61(37)21-4-16(66)20(79-21)8-75-85(71,72)82-19-3-15(78-36(19)64-33-25(60-40(64)44)29(48)52-12-56-33)7-74-84(69,70)81-18-2-14(77-35(18)63-32-24(59-39(63)43)28(47)51-11-55-32)6-73-83(67,68)80-17-1-13(5-65)76-34(17)62-31-23(58-38(62)42)27(46)50-10-54-31/h9-21,34-36,65-66H,1-8H2,(H,67,68)(H,69,70)(H,71,72)(H2,45,49,53)(H2,46,50,54)(H2,47,51,55)(H2,48,52,56)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extracts				J Med Chem 29: 1015-22 (1986) BindingDB Entry DOI: 10.7270/Q2SX6C6K
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Mus musculus)	BDBM50025004 (CHEMBL3143467 | p5'(br8A)2'p5'(br8A)2'p5'(br8A)2'p...) Show SMILES Nc1ncnc2n([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](CO)O[C@H]5n5c(Br)nc6c(N)ncnc56)O[C@H]4n4c(Br)nc5c(N)ncnc45)[C@@H](O)[C@H]3O)c(Br)nc12 |r| Show InChI InChI=1S/C50H57Br5N25O26P5/c51-46-71-27-32(56)61-11-66-37(27)76(46)26-5-20(81)25(102-26)10-97-111(91,92)106-24-4-19(101-45(24)80-41-31(75-50(80)55)36(60)65-15-70-41)9-96-110(89,90)105-23-3-18(100-44(23)79-40-30(74-49(79)54)35(59)64-14-69-40)8-95-109(87,88)104-22-2-17(99-43(22)78-39-29(73-48(78)53)34(58)63-13-68-39)7-94-108(85,86)103-21-1-16(6-93-107(82,83)84)98-42(21)77-38-28(72-47(77)52)33(57)62-12-67-38/h11-26,42-45,81H,1-10H2,(H,85,86)(H,87,88)(H,89,90)(H,91,92)(H2,56,61,66)(H2,57,62,67)(H2,58,63,68)(H2,59,64,69)(H2,60,65,70)(H2,82,83,84)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extracts				J Med Chem 29: 1015-22 (1986) BindingDB Entry DOI: 10.7270/Q2SX6C6K
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Mus musculus)	BDBM50024999 (CHEMBL414948 | Sulfuric acid mono-{5-(6-amino-puri...) Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C30H38N15O19P3/c31-22-13-25(37-4-34-22)43(7-40-13)28-19(49)16(46)10(60-28)2-58-66(53,54)64-21-18(48)12(62-30(21)45-9-42-15-24(33)36-6-39-27(15)45)3-59-67(55,56)63-20-17(47)11(1-57-65(50,51)52)61-29(20)44-8-41-14-23(32)35-5-38-26(14)44/h4-12,16-21,28-30,46-49H,1-3H2,(H,53,54)(H,55,56)(H2,31,34,37)(H2,32,35,38)(H2,33,36,39)(H2,50,51,52)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/m1/s1	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extracts				J Med Chem 29: 1015-22 (1986) BindingDB Entry DOI: 10.7270/Q2SX6C6K
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Mus musculus)	BDBM50024998 (CHEMBL3143412 | p5'(br8A)2'p5'(br8A)2'p5'(br8A)2'p...) Show SMILES Nc1ncnc2n([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)O[C@@H]6[C@H](O)[C@@H](CO)O[C@H]6n6c(Br)nc7c(N)ncnc67)O[C@H]5n5c(Br)nc6c(N)ncnc56)O[C@H]4n4c(Br)nc5c(N)ncnc45)[C@@H](O)[C@H]3O)c(Br)nc12 |r| Show InChI InChI=1S/C40H46Br4N20O21P4/c41-37-57-22-26(45)49-9-53-30(22)61(37)21-4-16(65)20(82-21)8-78-89(73,74)85-19-3-15(81-36(19)64-33-25(60-40(64)44)29(48)52-12-56-33)7-77-88(71,72)84-18-2-14(80-35(18)63-32-24(59-39(63)43)28(47)51-11-55-32)6-76-87(69,70)83-17-1-13(5-75-86(66,67)68)79-34(17)62-31-23(58-38(62)42)27(46)50-10-54-31/h9-21,34-36,65H,1-8H2,(H,69,70)(H,71,72)(H,73,74)(H2,45,49,53)(H2,46,50,54)(H2,47,51,55)(H2,48,52,56)(H2,66,67,68)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extracts				J Med Chem 29: 1015-22 (1986) BindingDB Entry DOI: 10.7270/Q2SX6C6K
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Homo sapiens (Human))	BDBM50085558 (CHEMBL402676 | Oligoadenylate analogue) Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]5n5cnc6c(N)ncnc56)O[C@H]4n4cnc5c(N)ncnc45)[C@@H](O)[C@H]3O)c2n1 Show InChI InChI=1S/C31H40N15O19P3/c1-10-42-25(34)16-28(43-10)46(9-41-16)29-20(50)17(47)11(61-29)3-59-67(54,55)65-22-19(49)13(63-31(22)45-8-40-15-24(33)36-6-38-27(15)45)4-60-68(56,57)64-21-18(48)12(2-58-66(51,52)53)62-30(21)44-7-39-14-23(32)35-5-37-26(14)44/h5-9,11-13,17-22,29-31,47-50H,2-4H2,1H3,(H,54,55)(H,56,57)(H2,32,35,37)(H2,33,36,38)(H2,34,42,43)(H2,51,52,53)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	0.200	n/a	n/a	n/a	n/a
Gifu University Curated by ChEMBL					Assay Description Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of [32P]-pC11U2C7				Bioorg Med Chem Lett 10: 329-31 (2000) BindingDB Entry DOI: 10.7270/Q2TM79B4
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Homo sapiens (Human))	BDBM50085555 (CHEMBL384725 | Oligoadenylate analogue) Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3OP(O)(=O)OC[C@H]3O[C@H]([C@H](OP(O)(=O)OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)n4cnc5c(N)ncnc45)[C@@H]3O)n3cnc4c(N)ncnc34)c2n1 Show InChI InChI=1S/C31H40N15O19P3/c1-10-42-25(34)16-28(43-10)46(9-41-16)31-22(18(48)12(62-31)2-58-66(51,52)53)65-68(56,57)60-4-13-19(49)21(30(63-13)45-8-40-15-24(33)36-6-38-27(15)45)64-67(54,55)59-3-11-17(47)20(50)29(61-11)44-7-39-14-23(32)35-5-37-26(14)44/h5-9,11-13,17-22,29-31,47-50H,2-4H2,1H3,(H,54,55)(H,56,57)(H2,32,35,37)(H2,33,36,38)(H2,34,42,43)(H2,51,52,53)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	0.840	n/a	n/a	n/a	n/a
Gifu University Curated by ChEMBL					Assay Description Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease L				Bioorg Med Chem Lett 10: 329-31 (2000) BindingDB Entry DOI: 10.7270/Q2TM79B4
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Homo sapiens (Human))	BDBM50085554 (5'-O-MONOPHOSPHORYLADENYLYL(2'->5')ADENYLYL(2'->5'...) Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O Show InChI InChI=1S/C30H38N15O19P3/c31-22-13-25(37-4-34-22)43(7-40-13)28-19(49)16(46)10(60-28)2-58-66(53,54)64-21-18(48)12(62-30(21)45-9-42-15-24(33)36-6-39-27(15)45)3-59-67(55,56)63-20-17(47)11(1-57-65(50,51)52)61-29(20)44-8-41-14-23(32)35-5-38-26(14)44/h4-12,16-21,28-30,46-49H,1-3H2,(H,53,54)(H,55,56)(H2,31,34,37)(H2,32,35,38)(H2,33,36,39)(H2,50,51,52)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Similars	MMDB PubMed	n/a	n/a	n/a	n/a	0.150	n/a	n/a	n/a	n/a
Gifu University Curated by ChEMBL					Assay Description Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of poly (U) 3'[32P]p5'C3'p				Bioorg Med Chem Lett 10: 329-31 (2000) BindingDB Entry DOI: 10.7270/Q2TM79B4
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Homo sapiens (Human))	BDBM50085559 (CHEMBL410213 | Oligoadenylate analogue) Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]5n5cnc6c(N)nc(C)nc56)O[C@H]4n4cnc5c(N)nc(C)nc45)[C@@H](O)[C@H]3O)c2n1 Show InChI InChI=1S/C33H46N15O25P5/c1-10-40-25(34)16-28(43-10)46(7-37-16)31-22(52)19(49)13(67-31)4-64-75(56,57)70-23-20(50)14(68-32(23)47-8-38-17-26(35)41-11(2)44-29(17)47)5-65-76(58,59)71-24-21(51)15(6-66-77(60,61)73-78(62,63)72-74(53,54)55)69-33(24)48-9-39-18-27(36)42-12(3)45-30(18)48/h7-9,13-15,19-24,31-33,49-52H,4-6H2,1-3H3,(H,56,57)(H,58,59)(H,60,61)(H,62,63)(H2,34,40,43)(H2,35,41,44)(H2,36,42,45)(H2,53,54,55)/t13-,14-,15-,19-,20-,21-,22-,23-,24-,31-,32-,33-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	4	n/a	n/a	n/a	n/a
Gifu University Curated by ChEMBL					Assay Description Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease L				Bioorg Med Chem Lett 10: 329-31 (2000) BindingDB Entry DOI: 10.7270/Q2TM79B4
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Homo sapiens (Human))	BDBM50085556 (CHEMBL405496 | Oligoadenylate analogue) Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3OP(O)(=O)OC[C@H]3O[C@H]([C@H](OP(O)(=O)OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)n4cnc5c(N)ncnc45)[C@@H]3O)n3cnc4c(N)ncnc34)c2n1 Show InChI InChI=1S/C31H42N15O25P5/c1-10-42-25(34)16-28(43-10)46(9-41-16)31-22(19(49)13(67-31)4-64-75(58,59)71-76(60,61)70-72(51,52)53)69-74(56,57)63-3-12-18(48)21(30(66-12)45-8-40-15-24(33)36-6-38-27(15)45)68-73(54,55)62-2-11-17(47)20(50)29(65-11)44-7-39-14-23(32)35-5-37-26(14)44/h5-9,11-13,17-22,29-31,47-50H,2-4H2,1H3,(H,54,55)(H,56,57)(H,58,59)(H,60,61)(H2,32,35,37)(H2,33,36,38)(H2,34,42,43)(H2,51,52,53)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	0.800	n/a	n/a	n/a	n/a
Gifu University Curated by ChEMBL					Assay Description Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease L				Bioorg Med Chem Lett 10: 329-31 (2000) BindingDB Entry DOI: 10.7270/Q2TM79B4
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Homo sapiens (Human))	BDBM50085559 (CHEMBL410213 | Oligoadenylate analogue) Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]5n5cnc6c(N)nc(C)nc56)O[C@H]4n4cnc5c(N)nc(C)nc45)[C@@H](O)[C@H]3O)c2n1 Show InChI InChI=1S/C33H46N15O25P5/c1-10-40-25(34)16-28(43-10)46(7-37-16)31-22(52)19(49)13(67-31)4-64-75(56,57)70-23-20(50)14(68-32(23)47-8-38-17-26(35)41-11(2)44-29(17)47)5-65-76(58,59)71-24-21(51)15(6-66-77(60,61)73-78(62,63)72-74(53,54)55)69-33(24)48-9-39-18-27(36)42-12(3)45-30(18)48/h7-9,13-15,19-24,31-33,49-52H,4-6H2,1-3H3,(H,56,57)(H,58,59)(H,60,61)(H,62,63)(H2,34,40,43)(H2,35,41,44)(H2,36,42,45)(H2,53,54,55)/t13-,14-,15-,19-,20-,21-,22-,23-,24-,31-,32-,33-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	4.60	n/a	n/a	n/a	n/a
Gifu University Curated by ChEMBL					Assay Description Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of [32P]-pC11U2C7				Bioorg Med Chem Lett 10: 329-31 (2000) BindingDB Entry DOI: 10.7270/Q2TM79B4
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Homo sapiens (Human))	BDBM50085555 (CHEMBL384725 | Oligoadenylate analogue) Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3OP(O)(=O)OC[C@H]3O[C@H]([C@H](OP(O)(=O)OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)n4cnc5c(N)ncnc45)[C@@H]3O)n3cnc4c(N)ncnc34)c2n1 Show InChI InChI=1S/C31H40N15O19P3/c1-10-42-25(34)16-28(43-10)46(9-41-16)31-22(18(48)12(62-31)2-58-66(51,52)53)65-68(56,57)60-4-13-19(49)21(30(63-13)45-8-40-15-24(33)36-6-38-27(15)45)64-67(54,55)59-3-11-17(47)20(50)29(61-11)44-7-39-14-23(32)35-5-37-26(14)44/h5-9,11-13,17-22,29-31,47-50H,2-4H2,1H3,(H,54,55)(H,56,57)(H2,32,35,37)(H2,33,36,38)(H2,34,42,43)(H2,51,52,53)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	0.700	n/a	n/a	n/a	n/a
Gifu University Curated by ChEMBL					Assay Description Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of [32P]-pC11U2C7				Bioorg Med Chem Lett 10: 329-31 (2000) BindingDB Entry DOI: 10.7270/Q2TM79B4
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Homo sapiens (Human))	BDBM50085556 (CHEMBL405496 | Oligoadenylate analogue) Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3OP(O)(=O)OC[C@H]3O[C@H]([C@H](OP(O)(=O)OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)n4cnc5c(N)ncnc45)[C@@H]3O)n3cnc4c(N)ncnc34)c2n1 Show InChI InChI=1S/C31H42N15O25P5/c1-10-42-25(34)16-28(43-10)46(9-41-16)31-22(19(49)13(67-31)4-64-75(58,59)71-76(60,61)70-72(51,52)53)69-74(56,57)63-3-12-18(48)21(30(66-12)45-8-40-15-24(33)36-6-38-27(15)45)68-73(54,55)62-2-11-17(47)20(50)29(65-11)44-7-39-14-23(32)35-5-37-26(14)44/h5-9,11-13,17-22,29-31,47-50H,2-4H2,1H3,(H,54,55)(H,56,57)(H,58,59)(H,60,61)(H2,32,35,37)(H2,33,36,38)(H2,34,42,43)(H2,51,52,53)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	0.680	n/a	n/a	n/a	n/a
Gifu University Curated by ChEMBL					Assay Description Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of [32P]-pC11U2C7				Bioorg Med Chem Lett 10: 329-31 (2000) BindingDB Entry DOI: 10.7270/Q2TM79B4
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Homo sapiens (Human))	BDBM50085557 (CHEMBL407239 | Oligoadenylate analogue) Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]5n5cnc6c(N)nc(C)nc56)O[C@H]4n4cnc5c(N)nc(C)nc45)[C@@H](O)[C@H]3O)c2n1 Show InChI InChI=1S/C33H44N15O19P3/c1-10-40-25(34)16-28(43-10)46(7-37-16)31-22(52)19(49)13(63-31)5-61-69(56,57)67-24-21(51)15(65-33(24)48-9-39-18-27(36)42-12(3)45-30(18)48)6-62-70(58,59)66-23-20(50)14(4-60-68(53,54)55)64-32(23)47-8-38-17-26(35)41-11(2)44-29(17)47/h7-9,13-15,19-24,31-33,49-52H,4-6H2,1-3H3,(H,56,57)(H,58,59)(H2,34,40,43)(H2,35,41,44)(H2,36,42,45)(H2,53,54,55)/t13-,14-,15-,19-,20-,21-,22-,23-,24-,31-,32-,33-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	16	n/a	n/a	n/a	n/a
Gifu University Curated by ChEMBL					Assay Description Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of poly (U) 3'[32P]p5'C3'p				Bioorg Med Chem Lett 10: 329-31 (2000) BindingDB Entry DOI: 10.7270/Q2TM79B4
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Homo sapiens (Human))	BDBM50085554 (5'-O-MONOPHOSPHORYLADENYLYL(2'->5')ADENYLYL(2'->5'...) Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O Show InChI InChI=1S/C30H38N15O19P3/c31-22-13-25(37-4-34-22)43(7-40-13)28-19(49)16(46)10(60-28)2-58-66(53,54)64-21-18(48)12(62-30(21)45-9-42-15-24(33)36-6-39-27(15)45)3-59-67(55,56)63-20-17(47)11(1-57-65(50,51)52)61-29(20)44-8-41-14-23(32)35-5-38-26(14)44/h4-12,16-21,28-30,46-49H,1-3H2,(H,53,54)(H,55,56)(H2,31,34,37)(H2,32,35,38)(H2,33,36,39)(H2,50,51,52)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Similars	MMDB PubMed	n/a	n/a	n/a	n/a	0.200	n/a	n/a	n/a	n/a
Gifu University Curated by ChEMBL					Assay Description Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of [32P]-pC11U2C7				Bioorg Med Chem Lett 10: 329-31 (2000) BindingDB Entry DOI: 10.7270/Q2TM79B4
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Homo sapiens (Human))	BDBM50085557 (CHEMBL407239 | Oligoadenylate analogue) Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]5n5cnc6c(N)nc(C)nc56)O[C@H]4n4cnc5c(N)nc(C)nc45)[C@@H](O)[C@H]3O)c2n1 Show InChI InChI=1S/C33H44N15O19P3/c1-10-40-25(34)16-28(43-10)46(7-37-16)31-22(52)19(49)13(63-31)5-61-69(56,57)67-24-21(51)15(65-33(24)48-9-39-18-27(36)42-12(3)45-30(18)48)6-62-70(58,59)66-23-20(50)14(4-60-68(53,54)55)64-32(23)47-8-38-17-26(35)41-11(2)44-29(17)47/h7-9,13-15,19-24,31-33,49-52H,4-6H2,1-3H3,(H,56,57)(H,58,59)(H2,34,40,43)(H2,35,41,44)(H2,36,42,45)(H2,53,54,55)/t13-,14-,15-,19-,20-,21-,22-,23-,24-,31-,32-,33-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a
Gifu University Curated by ChEMBL					Assay Description Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of [32P]-pC11U2C7				Bioorg Med Chem Lett 10: 329-31 (2000) BindingDB Entry DOI: 10.7270/Q2TM79B4
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Homo sapiens (Human))	BDBM50421415 (CHEMBL414948) Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@](O)(=O)O[C@@H]2[C@H](O)[C@@H](CO[P@](O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C30H38N15O19P3/c31-22-13-25(37-4-34-22)43(7-40-13)28-19(49)16(46)10(60-28)2-58-66(53,54)64-21-18(48)12(62-30(21)45-9-42-15-24(33)36-6-39-27(15)45)3-59-67(55,56)63-20-17(47)11(1-57-65(50,51)52)61-29(20)44-8-41-14-23(32)35-5-38-26(14)44/h4-12,16-21,28-30,46-49H,1-3H2,(H,53,54)(H,55,56)(H2,31,34,37)(H2,32,35,38)(H2,33,36,39)(H2,50,51,52)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB PubMed	n/a	n/a	n/a	n/a	0.210	n/a	n/a	n/a	n/a
National Institute of Diabetes and Digestive antd Kidney Diseases Curated by ChEMBL					Assay Description Binding affinity of compound to human recombinant Ribonuclease L was evaluated				Bioorg Med Chem Lett 10: 1357-60 (2000) BindingDB Entry DOI: 10.7270/Q2TT4Q67
					More data for this Ligand-Target Pair				3D Structure (crystal)
2-5A-dependent ribonuclease (Homo sapiens (Human))	BDBM50085553 (CHEMBL214603 | Oligoadenylate analogue) Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]5n5cnc6c(N)ncnc56)O[C@H]4n4cnc5c(N)ncnc45)[C@@H](O)[C@H]3O)c2n1 Show InChI InChI=1S/C31H42N15O25P5/c1-10-42-25(34)16-28(43-10)46(9-41-16)29-20(50)17(47)11(65-29)2-62-73(54,55)68-21-18(48)12(66-30(21)44-7-39-14-23(32)35-5-37-26(14)44)3-63-74(56,57)69-22-19(49)13(4-64-75(58,59)71-76(60,61)70-72(51,52)53)67-31(22)45-8-40-15-24(33)36-6-38-27(15)45/h5-9,11-13,17-22,29-31,47-50H,2-4H2,1H3,(H,54,55)(H,56,57)(H,58,59)(H,60,61)(H2,32,35,37)(H2,33,36,38)(H2,34,42,43)(H2,51,52,53)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	0.240	n/a	n/a	n/a	n/a
Gifu University Curated by ChEMBL					Assay Description Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of poly (U) 3'[32P]p5'C3'p				Bioorg Med Chem Lett 10: 329-31 (2000) BindingDB Entry DOI: 10.7270/Q2TM79B4
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Homo sapiens (Human))	BDBM50085558 (CHEMBL402676 | Oligoadenylate analogue) Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]5n5cnc6c(N)ncnc56)O[C@H]4n4cnc5c(N)ncnc45)[C@@H](O)[C@H]3O)c2n1 Show InChI InChI=1S/C31H40N15O19P3/c1-10-42-25(34)16-28(43-10)46(9-41-16)29-20(50)17(47)11(61-29)3-59-67(54,55)65-22-19(49)13(63-31(22)45-8-40-15-24(33)36-6-38-27(15)45)4-60-68(56,57)64-21-18(48)12(2-58-66(51,52)53)62-30(21)44-7-39-14-23(32)35-5-37-26(14)44/h5-9,11-13,17-22,29-31,47-50H,2-4H2,1H3,(H,54,55)(H,56,57)(H2,32,35,37)(H2,33,36,38)(H2,34,42,43)(H2,51,52,53)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	0.130	n/a	n/a	n/a	n/a
Gifu University Curated by ChEMBL					Assay Description Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of poly (U) 3'[32P]p5'C3'p				Bioorg Med Chem Lett 10: 329-31 (2000) BindingDB Entry DOI: 10.7270/Q2TM79B4
					More data for this Ligand-Target Pair
2-5A-dependent ribonuclease (Homo sapiens (Human))	BDBM50085553 (CHEMBL214603 | Oligoadenylate analogue) Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]5n5cnc6c(N)ncnc56)O[C@H]4n4cnc5c(N)ncnc45)[C@@H](O)[C@H]3O)c2n1 Show InChI InChI=1S/C31H42N15O25P5/c1-10-42-25(34)16-28(43-10)46(9-41-16)29-20(50)17(47)11(65-29)2-62-73(54,55)68-21-18(48)12(66-30(21)44-7-39-14-23(32)35-5-37-26(14)44)3-63-74(56,57)69-22-19(49)13(4-64-75(58,59)71-76(60,61)70-72(51,52)53)67-31(22)45-8-40-15-24(33)36-6-38-27(15)45/h5-9,11-13,17-22,29-31,47-50H,2-4H2,1H3,(H,54,55)(H,56,57)(H,58,59)(H,60,61)(H2,32,35,37)(H2,33,36,38)(H2,34,42,43)(H2,51,52,53)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a
Gifu University Curated by ChEMBL					Assay Description Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of poly (U) 3'[32P]p5'C3'p				Bioorg Med Chem Lett 10: 329-31 (2000) BindingDB Entry DOI: 10.7270/Q2TM79B4
					More data for this Ligand-Target Pair