| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50405399 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_53612 (CHEMBL661842) |
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| IC50 | 20±n/a nM |
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| Citation |  DeGraw, JI; Christie, PH; Tagawa, H; Kisliuk, RL; Gaumont, Y; Schmid, FA; Sirotnak, FM Synthesis and biological activity of resolved C-10 diastereomers of 10-methyl- and 10-ethyl-10-deazaminopterin. J Med Chem29:1056-61 (1986) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | 1.5.1.3 | DHFR | DYR_CHICK |
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| Type: | n/a |
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| Mol. Mass.: | 21652.69 |
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| Organism: | Gallus gallus (Chicken) |
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| Description: | n/a |
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| Residue: | 189 |
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| Sequence: | VRSLNSIVAVCQNMGIGKDGNLPWPPLRNEYKYFQRMTSTSHVEGKQNAVIMGKKTWFSI
PEKNRPLKDRINIVLSRELKEAPKGAHYLSKSLDDALALLDSPELKSKVDMVWIVGGTAV
YKAAMEKPINHRLFVTRILHEFESDTFFPEIDYKDFKLLTEYPGVPADIQEEDGIQYKFE
VYQKSVLAQ
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| BDBM50405399 |
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| n/a |
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| Name | BDBM50405399 |
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| Synonyms: | CHEMBL2051989 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H29N7O5 |
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| Mol. Mass. | 471.5096 |
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| SMILES | CC[C@H](CC1CNc2nc(N)nc(N)c2N1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O |r| |
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| Structure | 
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