| Reaction Details |
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 | Report a problem with these data |
| Target | Fibroblast growth factor receptor 4 |
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| Ligand | BDBM209268 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1784239 (CHEMBL4255756) |
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| IC50 | 24±n/a nM |
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| Citation |  Knoepfel, T; Furet, P; Mah, R; Buschmann, N; Leblanc, C; Ripoche, S; Graus-Porta, D; Wartmann, M; Galuba, I; Fairhurst, RA 2-Formylpyridyl Ureas as Highly Selective Reversible-Covalent Inhibitors of Fibroblast Growth Factor Receptor 4. ACS Med Chem Lett9:215-220 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Fibroblast growth factor receptor 4 |
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| Name: | Fibroblast growth factor receptor 4 |
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| Synonyms: | CD_antigen: CD334 FGFR4 | FGFR-4 | FGFR4 | FGFR4_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 4 (FGFR4) | JK2 | JTK2 | TKF |
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| Type: | Protein |
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| Mol. Mass.: | 87957.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22455 |
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| Residue: | 802 |
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| Sequence: | MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRA
ERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDS
LTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP
TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD
VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP
YVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTA
AAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSL
ESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQ
VVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVC
TQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGM
QYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEA
LFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYG
LMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDS
VFSHDPLPLGSSSFPFGSGVQT
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| BDBM209268 |
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| n/a |
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| Name | BDBM209268 |
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| Synonyms: | US9266883, 26 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24N6O3 |
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| Mol. Mass. | 420.4644 |
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| SMILES | CC1(O)CCN(CC1)c1cc(NC(=O)N2CCCc3ccc(C=O)nc23)ncc1C#N |
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| Structure | 
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