| Reaction Details |
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 | Report a problem with these data |
| Target | WD repeat-containing protein 5 |
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| Ligand | BDBM50465585 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1785272 (CHEMBL4256789) |
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| Ki | 2.7±n/a nM |
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| Citation |  Wang, F; Jeon, KO; Salovich, JM; Macdonald, JD; Alvarado, J; Gogliotti, RD; Phan, J; Olejniczak, ET; Sun, Q; Wang, S; Camper, D; Yuh, JP; Shaw, JG; Sai, J; Rossanese, OW; Tansey, WP; Stauffer, SR; Fesik, SW Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design. J Med Chem61:5623-5642 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| WD repeat-containing protein 5 |
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| Name: | WD repeat-containing protein 5 |
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| Synonyms: | BIG3 | WD repeat-containing protein 5 | WD repeat-containing protein 5 (WDR5) | WD repeat-containing protein 5 (WRD5) | WDR5 | WDR5_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 36597.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P61964 |
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| Residue: | 334 |
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| Sequence: | MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL
ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK
CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN
RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL
WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH
TDVVISTACHPTENIIASAALENDKTIKLWKSDC
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| BDBM50465585 |
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| n/a |
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| Name | BDBM50465585 |
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| Synonyms: | CHEMBL4279907 | US10501466, Example B11 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H21Cl2N3O |
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| Mol. Mass. | 426.338 |
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| SMILES | Clc1ccc(CC(=O)N[C@@H]2CCc3ccc(cc23)-c2cn3CCCc3n2)cc1Cl |r| |
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| Structure | 
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