| Reaction Details |
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 | Report a problem with these data |
| Target | Vasopressin V1b receptor |
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| Ligand | BDBM50466882 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1794570 (CHEMBL4266687) |
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| Ki | 1.1±n/a nM |
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| Citation |  Geneste, H; Bhowmik, S; van Gaalen, MM; Hornberger, W; Hutchins, CW; Netz, A; Oost, T; Unger, L Novel, potent, selective and brain penetrant vasopressin 1b receptor antagonists. Bioorg Med Chem Lett28:3260-3264 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Vasopressin V1b receptor |
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| Name: | Vasopressin V1b receptor |
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| Synonyms: | AVPR V1b | AVPR V3 | AVPR1B | AVPR3 | Antidiuretic hormone receptor 1b | V1BR_HUMAN | V1bR | VASOPRESSIN V1B | VPR3 | Vasopressin V1b receptor | Vasopressin V1b receptor (V1b) | Vasopressin V3 | Vasopressin V3 receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 46985.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P47901 |
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| Residue: | 424 |
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| Sequence: | MDSGPLWDANPTPRGTLSAPNATTPWLGRDEELAKVEIGVLATVLVLATGGNLAVLLTLG
QLGRKRSRMHLFVLHLALTDLAVALFQVLPQLLWDITYRFQGPDLLCRAVKYLQVLSMFA
STYMLLAMTLDRYLAVCHPLRSLQQPGQSTYLLIAAPWLLAAIFSLPQVFIFSLREVIQG
SGVLDCWADFGFPWGPRAYLTWTTLAIFVLPVTMLTACYSLICHEICKNLKVKTQAWRVG
GGGWRTWDRPSPSTLAATTRGLPSRVSSINTISRAKIRTVKMTFVIVLAYIACWAPFFSV
QMWSVWDKNAPDEDSTNVAFTISMLLGNLNSCCNPWIYMGFNSHLLPRPLRHLACCGGPQ
PRMRRRLSDGSLSSRHTTLLTRSSCPATLSLSLSLTLSGRPRPEESPRDLELADGEGTAE
TIIF
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| BDBM50466882 |
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| n/a |
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| Name | BDBM50466882 |
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| Synonyms: | CHEMBL4280894 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H28ClN7O5S |
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| Mol. Mass. | 646.116 |
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| SMILES | CCOc1nc(Cl)ccc1C1(N2CCN(CC2)c2ccncc2)C(=O)N(c2ccc(cc12)C#N)S(=O)(=O)c1ccc(OC)cn1 |
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| Structure | 
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