| Reaction Details |
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 | Report a problem with these data |
| Target | Urease subunit beta |
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| Ligand | BDBM50099857 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1794866 (CHEMBL4266983) |
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| IC50 | 17200±n/a nM |
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| Citation |  Yang, YS; Su, MM; Zhang, XP; Liu, QX; He, ZX; Xu, C; Zhu, HL Developing potential Helicobacter pylori urease inhibitors from novel oxoindoline derivatives: Synthesis, biological evaluation and in silico study. Bioorg Med Chem Lett28:3182-3186 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Urease subunit beta |
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| Name: | Urease subunit beta |
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| Synonyms: | 3.5.1.5 | Urea amidohydrolase subunit beta | Urease subunit beta | ureB |
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| Type: | PROTEIN |
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| Mol. Mass.: | 61708.53 |
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| Organism: | Helicobacter pylori |
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| Description: | ChEMBL_100923 |
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| Residue: | 569 |
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| Sequence: | MKKISRKEYVSMYGPTTGDKVRLGDTDLIAEVEHDYTIYGEELKFGGGKTLREGMSQSNN
PSKEELDLIITNALIVDYTGIYKADIGIKDGKIAGIGKGGNKDMQDGVKNNLSVGPATEA
LAGEGLIVTAGGIDTHIHFISPQQIPTAFASGITTMIGGGTGPADGTNATTITPGRRNLK
WMLRAAEEYSMNLGFLAKGNTSNDASLADQIEAGAIGFKIHEDWGTTPSAINHALDVADK
YDVQVAIHTDTLNEAGCVEDTMAAIAGRTMHTFHTEGAGGGHAPDIIKVAGEHNILPAST
NPTIPFTVNTEAEHMDMLMVCHHLDKSIKEDVQFADSRIRPQTIAAEDTLHDMGIFSITS
SDSQAMGRVGEVITRTWQTADKNKKEFGRLKEEKGDNDNFRIKRYLSKYTINPAIAHGIS
EYVGSVEVGKVADLVLWSPAFFGVKPNMIIKGGFIALSQMGDANASIPTPQPVYYREMFA
HHGKAKYDANITFVSKAAYDKGIKEELGLERQVLPVKNCRNITKKDMQFNDTTAHIEVNP
ETYHVFVDGKEVTSKPATKVSLAQLFSIF
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| BDBM50099857 |
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| n/a |
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| Name | BDBM50099857 |
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| Synonyms: | ACETOHYDROXAMIC ACID (AHA) | AHA | Acethydroxamsaeure | Acethydroxamsaure | Acetic acid, oxime | Acetylhydroxamic acid | Cetohyroxamic acid | Lithostat | Methylhydroxamic acid | N-Acetyl hydroxyacetamide | N-Acetylhydroxylamine | N-Hydroxyacetamide | acetohydroxamic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C2H5NO2 |
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| Mol. Mass. | 75.0666 |
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| SMILES | CC(=O)NO |
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| Structure | 
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