Reaction Details |
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Target | Farnesyl pyrophosphate synthase |
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Ligand | BDBM12576 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1795608 (CHEMBL4267725) |
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IC50 | 70±n/a nM |
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Citation | Savino, S; Toscano, A; Purgatorio, R; Profilo, E; Laghezza, A; Tortorella, P; Angelelli, M; Cellamare, S; Scala, R; Tricarico, D; Marobbio, CMT; Perna, F; Vitale, P; Agamennone, M; Dimiccoli, V; Tolomeo, A; Scilimati, A Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis. Eur J Med Chem158:184-200 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Farnesyl pyrophosphate synthase |
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Name: | Farnesyl pyrophosphate synthase |
Synonyms: | Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324 |
Type: | Enzyme |
Mol. Mass.: | 48272.89 |
Organism: | Homo sapiens (Human) |
Description: | P14324 |
Residue: | 419 |
Sequence: | MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA
LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI
GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG
QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD
LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE
MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE
AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
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BDBM12576 |
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n/a |
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Name | BDBM12576 |
Synonyms: | Bisphosphonate 1 | CHEMBL923 | JMC515594 Compound 64 | RIS | Risdronate | US11279719, Example Risedronic acid RIS | [1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethyl]phosphonic acid |
Type | Small organic molecule |
Emp. Form. | C7H11NO7P2 |
Mol. Mass. | 283.1123 |
SMILES | OC(Cc1cccnc1)(P(O)(O)=O)P(O)(O)=O |
Structure |
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