Found 1228 hits with Last Name = 'tortorella' and Initial = 'p' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Neutrophil collagenase
(Homo sapiens (Human)) | BDBM12072
((R)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...)Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)P(O)(O)=O |r| Show InChI InChI=1S/C17H22NO6PS/c1-12(2)17(25(19,20)21)18-26(22,23)16-10-6-14(7-11-16)13-4-8-15(24-3)9-5-13/h4-12,17-18H,1-3H3,(H2,19,20,21)/t17-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| MMDB PDB Article PubMed
| 0.600 | -52.6 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Istituto di Cristallografia
| Assay Description Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ... |
J Med Chem 49: 923-31 (2006)
Article DOI: 10.1021/jm050787+ BindingDB Entry DOI: 10.7270/Q2348HM7 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Stromelysin-1
(Homo sapiens (Human)) | BDBM12075
((2S)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1)C(O)=O |r| Show InChI InChI=1S/C17H18BrNO4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,1-2H3,(H,20,21)/t16-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| 4.40 | -47.7 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Istituto di Cristallografia
| Assay Description Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ... |
J Med Chem 49: 923-31 (2006)
Article DOI: 10.1021/jm050787+ BindingDB Entry DOI: 10.7270/Q2348HM7 |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM12072
((R)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...)Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)P(O)(O)=O |r| Show InChI InChI=1S/C17H22NO6PS/c1-12(2)17(25(19,20)21)18-26(22,23)16-10-6-14(7-11-16)13-4-8-15(24-3)9-5-13/h4-12,17-18H,1-3H3,(H2,19,20,21)/t17-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| 5 | -47.4 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Istituto di Cristallografia
| Assay Description Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ... |
J Med Chem 49: 923-31 (2006)
Article DOI: 10.1021/jm050787+ BindingDB Entry DOI: 10.7270/Q2348HM7 |
More data for this Ligand-Target Pair | |
Stromelysin-1
(Homo sapiens (Human)) | BDBM12072
((R)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...)Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)P(O)(O)=O |r| Show InChI InChI=1S/C17H22NO6PS/c1-12(2)17(25(19,20)21)18-26(22,23)16-10-6-14(7-11-16)13-4-8-15(24-3)9-5-13/h4-12,17-18H,1-3H3,(H2,19,20,21)/t17-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| 40 | -42.2 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Istituto di Cristallografia
| Assay Description Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ... |
J Med Chem 49: 923-31 (2006)
Article DOI: 10.1021/jm050787+ BindingDB Entry DOI: 10.7270/Q2348HM7 |
More data for this Ligand-Target Pair | |
Stromelysin-1
(Homo sapiens (Human)) | BDBM12074
((2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1)C(O)=O |r| Show InChI InChI=1S/C17H18BrNO4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,1-2H3,(H,20,21)/t16-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 54.9 | -41.4 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Istituto di Cristallografia
| Assay Description Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ... |
J Med Chem 49: 923-31 (2006)
Article DOI: 10.1021/jm050787+ BindingDB Entry DOI: 10.7270/Q2348HM7 |
More data for this Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM28681
(5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)...)Show InChI InChI=1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,22H,10-12H2,1H3,(H,20,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| 74 | -40.3 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Consiglio Nazionale delle Ricerche
| Assay Description The scintillation proximity assay was performed in 96-well plates containing polylysine-coated yttrium silicate beads, His-PPARgamma-LBD, and [3H]ros... |
J Biol Chem 282: 17314-24 (2007)
Article DOI: 10.1074/jbc.M702316200 BindingDB Entry DOI: 10.7270/Q27M0682 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM28681
(5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)...)Show InChI InChI=1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,22H,10-12H2,1H3,(H,20,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| 74 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istituto Tumori"Giovanni Paolo II"
Curated by ChEMBL
| Assay Description Displacement of [3H]rosiglitazone from N-terminal His-tagged human PPARgamma ligand binding domain expressed in Escherichia coli BL21 DE3 cells by sc... |
J Med Chem 55: 37-54 (2012)
Article DOI: 10.1021/jm201306q BindingDB Entry DOI: 10.7270/Q23N24JP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM28762
((2R)-2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]eth...)Show SMILES CCCCCCCN(CCc1ccc(O[C@](C)(CC)C(O)=O)cc1)c1nc2ccccc2o1 |r| Show InChI InChI=1S/C27H36N2O4/c1-4-6-7-8-11-19-29(26-28-23-12-9-10-13-24(23)32-26)20-18-21-14-16-22(17-15-21)33-27(3,5-2)25(30)31/h9-10,12-17H,4-8,11,18-20H2,1-3H3,(H,30,31)/t27-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| MMDB PC cid PC sid PDB UniChem
Similars
| MMDB PDB Article PubMed
| 88 | -39.9 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Consiglio Nazionale delle Ricerche
| Assay Description The scintillation proximity assay was performed in 96-well plates containing polylysine-coated yttrium silicate beads, His-PPARgamma-LBD, and [3H]ros... |
J Biol Chem 282: 17314-24 (2007)
Article DOI: 10.1074/jbc.M702316200 BindingDB Entry DOI: 10.7270/Q27M0682 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM28762
((2R)-2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]eth...)Show SMILES CCCCCCCN(CCc1ccc(O[C@](C)(CC)C(O)=O)cc1)c1nc2ccccc2o1 |r| Show InChI InChI=1S/C27H36N2O4/c1-4-6-7-8-11-19-29(26-28-23-12-9-10-13-24(23)32-26)20-18-21-14-16-22(17-15-21)33-27(3,5-2)25(30)31/h9-10,12-17H,4-8,11,18-20H2,1-3H3,(H,30,31)/t27-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| MMDB PC cid PC sid PDB UniChem
Similars
| MMDB PDB Article PubMed
| 88 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istituto Tumori"Giovanni Paolo II"
Curated by ChEMBL
| Assay Description Displacement of [3H]rosiglitazone from N-terminal His-tagged human PPARgamma ligand binding domain expressed in Escherichia coli BL21 DE3 cells by sc... |
J Med Chem 55: 37-54 (2012)
Article DOI: 10.1021/jm201306q BindingDB Entry DOI: 10.7270/Q23N24JP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Neutrophil collagenase
(Homo sapiens (Human)) | BDBM12073
((S)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...)Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@H](C(C)C)P(O)(O)=O |r| Show InChI InChI=1S/C17H22NO6PS/c1-12(2)17(25(19,20)21)18-26(22,23)16-10-6-14(7-11-16)13-4-8-15(24-3)9-5-13/h4-12,17-18H,1-3H3,(H2,19,20,21)/t17-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Similars
| MMDB PDB Article PubMed
| 700 | -35.1 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Istituto di Cristallografia
| Assay Description Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ... |
J Med Chem 49: 923-31 (2006)
Article DOI: 10.1021/jm050787+ BindingDB Entry DOI: 10.7270/Q2348HM7 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM28763
((2S)-2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]eth...)Show SMILES CCCCCCCN(CCc1ccc(O[C@@](C)(CC)C(O)=O)cc1)c1nc2ccccc2o1 |r| Show InChI InChI=1S/C27H36N2O4/c1-4-6-7-8-11-19-29(26-28-23-12-9-10-13-24(23)32-26)20-18-21-14-16-22(17-15-21)33-27(3,5-2)25(30)31/h9-10,12-17H,4-8,11,18-20H2,1-3H3,(H,30,31)/t27-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MMDB PC cid PC sid PDB UniChem
Similars
| MMDB PDB Article PubMed
| 971 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istituto Tumori"Giovanni Paolo II"
Curated by ChEMBL
| Assay Description Displacement of [3H]rosiglitazone from N-terminal His-tagged human PPARgamma ligand binding domain expressed in Escherichia coli BL21 DE3 cells by sc... |
J Med Chem 55: 37-54 (2012)
Article DOI: 10.1021/jm201306q BindingDB Entry DOI: 10.7270/Q23N24JP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM28763
((2S)-2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]eth...)Show SMILES CCCCCCCN(CCc1ccc(O[C@@](C)(CC)C(O)=O)cc1)c1nc2ccccc2o1 |r| Show InChI InChI=1S/C27H36N2O4/c1-4-6-7-8-11-19-29(26-28-23-12-9-10-13-24(23)32-26)20-18-21-14-16-22(17-15-21)33-27(3,5-2)25(30)31/h9-10,12-17H,4-8,11,18-20H2,1-3H3,(H,30,31)/t27-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MMDB PC cid PC sid PDB UniChem
Similars
| MMDB PDB Article PubMed
| 971 | -34.0 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Consiglio Nazionale delle Ricerche
| Assay Description The scintillation proximity assay was performed in 96-well plates containing polylysine-coated yttrium silicate beads, His-PPARgamma-LBD, and [3H]ros... |
J Biol Chem 282: 17314-24 (2007)
Article DOI: 10.1074/jbc.M702316200 BindingDB Entry DOI: 10.7270/Q27M0682 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM12073
((S)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...)Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@H](C(C)C)P(O)(O)=O |r| Show InChI InChI=1S/C17H22NO6PS/c1-12(2)17(25(19,20)21)18-26(22,23)16-10-6-14(7-11-16)13-4-8-15(24-3)9-5-13/h4-12,17-18H,1-3H3,(H2,19,20,21)/t17-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| 1.20E+3 | -33.8 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Istituto di Cristallografia
| Assay Description Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ... |
J Med Chem 49: 923-31 (2006)
Article DOI: 10.1021/jm050787+ BindingDB Entry DOI: 10.7270/Q2348HM7 |
More data for this Ligand-Target Pair | |
Neutrophil collagenase
(Homo sapiens (Human)) | BDBM50031795
((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)CC(=O)NO |r| Show InChI InChI=1S/C18H27N3O4/c1-12(2)9-14(11-16(22)21-25)17(23)20-15(18(24)19-3)10-13-7-5-4-6-8-13/h4-8,12,14-15,25H,9-11H2,1-3H3,(H,19,24)(H,20,23)(H,21,22)/t14-,15+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid UniChem
Patents
Similars
| MMDB Article PubMed
| n/a | n/a | 0.0460 | n/a | n/a | n/a | n/a | n/a | n/a |
Università G. d'Annunzio
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MMP8 |
Eur J Med Chem 43: 1008-14 (2008)
Article DOI: 10.1016/j.ejmech.2007.07.002 BindingDB Entry DOI: 10.7270/Q23T9H1W |
More data for this Ligand-Target Pair | |
Neutrophil collagenase
(Homo sapiens (Human)) | BDBM50198038
(CHEMBL227824 | [(R)-1-(4'-ethoxy-biphenyl-4-sulfon...)Show SMILES CCOc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)P(O)(O)=O Show InChI InChI=1S/C18H24NO6PS/c1-4-25-16-9-5-14(6-10-16)15-7-11-17(12-8-15)27(23,24)19-18(13(2)3)26(20,21)22/h5-13,18-19H,4H2,1-3H3,(H2,20,21,22)/t18-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.370 | n/a | n/a | n/a | n/a | n/a | n/a |
Università "G. d'Annunzio"
Curated by ChEMBL
| Assay Description Inhibition of MMP8 |
Bioorg Med Chem 15: 791-9 (2006)
Article DOI: 10.1016/j.bmc.2006.10.047 BindingDB Entry DOI: 10.7270/Q2DR2V4T |
More data for this Ligand-Target Pair | 3D Structure (docked) |
Matrix metalloproteinase-9
(Homo sapiens (Human)) | BDBM50031795
((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)CC(=O)NO |r| Show InChI InChI=1S/C18H27N3O4/c1-12(2)9-14(11-16(22)21-25)17(23)20-15(18(24)19-3)10-13-7-5-4-6-8-13/h4-8,12,14-15,25H,9-11H2,1-3H3,(H,19,24)(H,20,23)(H,21,22)/t14-,15+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.380 | n/a | n/a | n/a | n/a | n/a | n/a |
Università G. d'Annunzio
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MMP9 |
Eur J Med Chem 43: 1008-14 (2008)
Article DOI: 10.1016/j.ejmech.2007.07.002 BindingDB Entry DOI: 10.7270/Q23T9H1W |
More data for this Ligand-Target Pair | |
Neutrophil collagenase
(Homo sapiens (Human)) | BDBM50198033
(CHEMBL227484 | [(R)-2-methyl-1-(4'-methyl-biphenyl...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(C)cc1)P(O)(O)=O Show InChI InChI=1S/C17H22NO5PS/c1-12(2)17(24(19,20)21)18-25(22,23)16-10-8-15(9-11-16)14-6-4-13(3)5-7-14/h4-12,17-18H,1-3H3,(H2,19,20,21)/t17-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.390 | n/a | n/a | n/a | n/a | n/a | n/a |
Università "G. d'Annunzio"
Curated by ChEMBL
| Assay Description Inhibition of MMP8 |
Bioorg Med Chem 15: 791-9 (2006)
Article DOI: 10.1016/j.bmc.2006.10.047 BindingDB Entry DOI: 10.7270/Q2DR2V4T |
More data for this Ligand-Target Pair | 3D Structure (docked) |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50198038
(CHEMBL227824 | [(R)-1-(4'-ethoxy-biphenyl-4-sulfon...)Show SMILES CCOc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)P(O)(O)=O Show InChI InChI=1S/C18H24NO6PS/c1-4-25-16-9-5-14(6-10-16)15-7-11-17(12-8-15)27(23,24)19-18(13(2)3)26(20,21)22/h5-13,18-19H,4H2,1-3H3,(H2,20,21,22)/t18-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.390 | n/a | n/a | n/a | n/a | n/a | n/a |
Università "G. d'Annunzio"
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MMP2 expressed in mouse myeloma cells |
Bioorg Med Chem 15: 791-9 (2006)
Article DOI: 10.1016/j.bmc.2006.10.047 BindingDB Entry DOI: 10.7270/Q2DR2V4T |
More data for this Ligand-Target Pair | |
Neutrophil collagenase
(Homo sapiens (Human)) | BDBM50198033
(CHEMBL227484 | [(R)-2-methyl-1-(4'-methyl-biphenyl...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(C)cc1)P(O)(O)=O Show InChI InChI=1S/C17H22NO5PS/c1-12(2)17(24(19,20)21)18-25(22,23)16-10-8-15(9-11-16)14-6-4-13(3)5-7-14/h4-12,17-18H,1-3H3,(H2,19,20,21)/t17-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.390 | n/a | n/a | n/a | n/a | n/a | n/a |
Università "G. d'Annunzio"
Curated by ChEMBL
| Assay Description Inhibition of MMP8 |
Bioorg Med Chem 15: 791-9 (2006)
Article DOI: 10.1016/j.bmc.2006.10.047 BindingDB Entry DOI: 10.7270/Q2DR2V4T |
More data for this Ligand-Target Pair | 3D Structure (docked) |
Neutrophil collagenase
(Homo sapiens (Human)) | BDBM50198035
(CHEMBL227501 | [(R)-2-methyl-1-(3'-methyl-biphenyl...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1cccc(C)c1)P(O)(O)=O Show InChI InChI=1S/C17H22NO5PS/c1-12(2)17(24(19,20)21)18-25(22,23)16-9-7-14(8-10-16)15-6-4-5-13(3)11-15/h4-12,17-18H,1-3H3,(H2,19,20,21)/t17-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Università "G. d'Annunzio"
Curated by ChEMBL
| Assay Description Inhibition of MMP8 |
Bioorg Med Chem 15: 791-9 (2006)
Article DOI: 10.1016/j.bmc.2006.10.047 BindingDB Entry DOI: 10.7270/Q2DR2V4T |
More data for this Ligand-Target Pair | 3D Structure (docked) |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM26739
(3-(3-carbamoylphenyl)phenyl N-cyclohexylcarbamate ...)Show InChI InChI=1S/C20H22N2O3/c21-19(23)16-8-4-6-14(12-16)15-7-5-11-18(13-15)25-20(24)22-17-9-2-1-3-10-17/h4-8,11-13,17H,1-3,9-10H2,(H2,21,23)(H,22,24) | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari "Aldo Moro"
Curated by ChEMBL
| Assay Description Inhibition of FAAH in Wistar rat brain intact neurons assessed as reduction in [3H]anandamide hydrolysis using [3H]anandamide as substrate preincubat... |
J Med Chem 62: 10995-11003 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00885 BindingDB Entry DOI: 10.7270/Q26113K2 |
More data for this Ligand-Target Pair | |
Matrix metalloproteinase-9
(Homo sapiens (Human)) | BDBM50198038
(CHEMBL227824 | [(R)-1-(4'-ethoxy-biphenyl-4-sulfon...)Show SMILES CCOc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)P(O)(O)=O Show InChI InChI=1S/C18H24NO6PS/c1-4-25-16-9-5-14(6-10-16)15-7-11-17(12-8-15)27(23,24)19-18(13(2)3)26(20,21)22/h5-13,18-19H,4H2,1-3H3,(H2,20,21,22)/t18-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.560 | n/a | n/a | n/a | n/a | n/a | n/a |
Università "G. d'Annunzio"
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MMP9 expressed in mouse myeloma cells |
Bioorg Med Chem 15: 791-9 (2006)
Article DOI: 10.1016/j.bmc.2006.10.047 BindingDB Entry DOI: 10.7270/Q2DR2V4T |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50031795
((N-(2-HYDROXAMATEMETHYLENE-4-METHYL-PENTOYL)PHENYL...)Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)CC(=O)NO |r| Show InChI InChI=1S/C18H27N3O4/c1-12(2)9-14(11-16(22)21-25)17(23)20-15(18(24)19-3)10-13-7-5-4-6-8-13/h4-8,12,14-15,25H,9-11H2,1-3H3,(H,19,24)(H,20,23)(H,21,22)/t14-,15+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Università G. d'Annunzio
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MMP2 |
Eur J Med Chem 43: 1008-14 (2008)
Article DOI: 10.1016/j.ejmech.2007.07.002 BindingDB Entry DOI: 10.7270/Q23T9H1W |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Homo sapiens (Human)) | BDBM50593777
(CHEMBL5185868)Show SMILES [O-][N+](=O)c1cc(Cl)ccc1OCC(=O)NCCN1CCN(Cc2ccccc2)CC1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114358 BindingDB Entry DOI: 10.7270/Q2JS9VF3 |
More data for this Ligand-Target Pair | |
Neutrophil collagenase
(Homo sapiens (Human)) | BDBM50198034
(CHEMBL376557 | [(R)-1-(4'-chloro-biphenyl-4-sulfon...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(Cl)cc1)P(O)(O)=O Show InChI InChI=1S/C16H19ClNO5PS/c1-11(2)16(24(19,20)21)18-25(22,23)15-9-5-13(6-10-15)12-3-7-14(17)8-4-12/h3-11,16,18H,1-2H3,(H2,19,20,21)/t16-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.810 | n/a | n/a | n/a | n/a | n/a | n/a |
Università "G. d'Annunzio"
Curated by ChEMBL
| Assay Description Inhibition of MMP8 |
Bioorg Med Chem 15: 791-9 (2006)
Article DOI: 10.1016/j.bmc.2006.10.047 BindingDB Entry DOI: 10.7270/Q2DR2V4T |
More data for this Ligand-Target Pair | 3D Structure (docked) |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM8485
((2R)-N-hydroxy-3-methyl-2-[(4-phenoxybenzene)sulfo...)Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO |r| Show InChI InChI=1S/C17H20N2O5S/c1-12(2)16(17(20)18-21)19-25(22,23)15-10-8-14(9-11-15)24-13-6-4-3-5-7-13/h3-12,16,19,21H,1-2H3,(H,18,20)/t16-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Istituto di Cristallografia
| Assay Description Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ... |
J Med Chem 49: 923-31 (2006)
Article DOI: 10.1021/jm050787+ BindingDB Entry DOI: 10.7270/Q2348HM7 |
More data for this Ligand-Target Pair | |
Neutrophil collagenase
(Homo sapiens (Human)) | BDBM50198039
(CHEMBL374377 | [(R)-1-(4'-fluoro-biphenyl-4-sulfon...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(F)cc1)P(O)(O)=O Show InChI InChI=1S/C16H19FNO5PS/c1-11(2)16(24(19,20)21)18-25(22,23)15-9-5-13(6-10-15)12-3-7-14(17)8-4-12/h3-11,16,18H,1-2H3,(H2,19,20,21)/t16-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Università "G. d'Annunzio"
Curated by ChEMBL
| Assay Description Inhibition of MMP8 |
Bioorg Med Chem 15: 791-9 (2006)
Article DOI: 10.1016/j.bmc.2006.10.047 BindingDB Entry DOI: 10.7270/Q2DR2V4T |
More data for this Ligand-Target Pair | 3D Structure (docked) |
Collagenase 3
(Homo sapiens (Human)) | BDBM50198038
(CHEMBL227824 | [(R)-1-(4'-ethoxy-biphenyl-4-sulfon...)Show SMILES CCOc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)P(O)(O)=O Show InChI InChI=1S/C18H24NO6PS/c1-4-25-16-9-5-14(6-10-16)15-7-11-17(12-8-15)27(23,24)19-18(13(2)3)26(20,21)22/h5-13,18-19H,4H2,1-3H3,(H2,20,21,22)/t18-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Università "G. d'Annunzio"
Curated by ChEMBL
| Assay Description Inhibition of MMP13 |
Bioorg Med Chem 15: 791-9 (2006)
Article DOI: 10.1016/j.bmc.2006.10.047 BindingDB Entry DOI: 10.7270/Q2DR2V4T |
More data for this Ligand-Target Pair | |
Neutrophil collagenase
(Homo sapiens (Human)) | BDBM50198030
(CHEMBL228188 | [(R)-1-(3'-chloro-biphenyl-4-sulfon...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1cccc(Cl)c1)P(O)(O)=O Show InChI InChI=1S/C16H19ClNO5PS/c1-11(2)16(24(19,20)21)18-25(22,23)15-8-6-12(7-9-15)13-4-3-5-14(17)10-13/h3-11,16,18H,1-2H3,(H2,19,20,21)/t16-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Università "G. d'Annunzio"
Curated by ChEMBL
| Assay Description Inhibition of MMP8 |
Bioorg Med Chem 15: 791-9 (2006)
Article DOI: 10.1016/j.bmc.2006.10.047 BindingDB Entry DOI: 10.7270/Q2DR2V4T |
More data for this Ligand-Target Pair | 3D Structure (docked) |
Neutrophil collagenase
(Homo sapiens (Human)) | BDBM12072
((R)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...)Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)P(O)(O)=O |r| Show InChI InChI=1S/C17H22NO6PS/c1-12(2)17(25(19,20)21)18-26(22,23)16-10-6-14(7-11-16)13-4-8-15(24-3)9-5-13/h4-12,17-18H,1-3H3,(H2,19,20,21)/t17-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Università "G. d'Annunzio"
Curated by ChEMBL
| Assay Description Inhibition of MMP8 |
Bioorg Med Chem 15: 791-9 (2006)
Article DOI: 10.1016/j.bmc.2006.10.047 BindingDB Entry DOI: 10.7270/Q2DR2V4T |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM12072
((R)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...)Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)P(O)(O)=O |r| Show InChI InChI=1S/C17H22NO6PS/c1-12(2)17(25(19,20)21)18-26(22,23)16-10-6-14(7-11-16)13-4-8-15(24-3)9-5-13/h4-12,17-18H,1-3H3,(H2,19,20,21)/t17-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Università "G. d'Annunzio"
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MMP2 expressed in mouse myeloma cells |
Bioorg Med Chem 15: 791-9 (2006)
Article DOI: 10.1016/j.bmc.2006.10.047 BindingDB Entry DOI: 10.7270/Q2DR2V4T |
More data for this Ligand-Target Pair | |
Neutrophil collagenase
(Homo sapiens (Human)) | BDBM50198031
(CHEMBL227598 | [(R)-1-(4'-isopropoxy-biphenyl-4-su...)Show SMILES CC(C)Oc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)P(O)(O)=O Show InChI InChI=1S/C19H26NO6PS/c1-13(2)19(27(21,22)23)20-28(24,25)18-11-7-16(8-12-18)15-5-9-17(10-6-15)26-14(3)4/h5-14,19-20H,1-4H3,(H2,21,22,23)/t19-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Università "G. d'Annunzio"
Curated by ChEMBL
| Assay Description Inhibition of MMP8 |
Bioorg Med Chem 15: 791-9 (2006)
Article DOI: 10.1016/j.bmc.2006.10.047 BindingDB Entry DOI: 10.7270/Q2DR2V4T |
More data for this Ligand-Target Pair | 3D Structure (docked) |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50198031
(CHEMBL227598 | [(R)-1-(4'-isopropoxy-biphenyl-4-su...)Show SMILES CC(C)Oc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)P(O)(O)=O Show InChI InChI=1S/C19H26NO6PS/c1-13(2)19(27(21,22)23)20-28(24,25)18-11-7-16(8-12-18)15-5-9-17(10-6-15)26-14(3)4/h5-14,19-20H,1-4H3,(H2,21,22,23)/t19-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Università "G. d'Annunzio"
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MMP2 expressed in mouse myeloma cells |
Bioorg Med Chem 15: 791-9 (2006)
Article DOI: 10.1016/j.bmc.2006.10.047 BindingDB Entry DOI: 10.7270/Q2DR2V4T |
More data for this Ligand-Target Pair | |
Neutrophil collagenase
(Homo sapiens (Human)) | BDBM50198040
(CHEMBL389898 | [(R)-2-methyl-1-(4'-pyrrolidin-1-yl...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)N1CCCC1)P(O)(O)=O Show InChI InChI=1S/C20H27N2O5PS/c1-15(2)20(28(23,24)25)21-29(26,27)19-11-7-17(8-12-19)16-5-9-18(10-6-16)22-13-3-4-14-22/h5-12,15,20-21H,3-4,13-14H2,1-2H3,(H2,23,24,25)/t20-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Università "G. d'Annunzio"
Curated by ChEMBL
| Assay Description Inhibition of MMP8 |
Bioorg Med Chem 15: 791-9 (2006)
Article DOI: 10.1016/j.bmc.2006.10.047 BindingDB Entry DOI: 10.7270/Q2DR2V4T |
More data for this Ligand-Target Pair | 3D Structure (docked) |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50198033
(CHEMBL227484 | [(R)-2-methyl-1-(4'-methyl-biphenyl...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(C)cc1)P(O)(O)=O Show InChI InChI=1S/C17H22NO5PS/c1-12(2)17(24(19,20)21)18-25(22,23)16-10-8-15(9-11-16)14-6-4-13(3)5-7-14/h4-12,17-18H,1-3H3,(H2,19,20,21)/t17-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Università "G. d'Annunzio"
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MMP2 expressed in mouse myeloma cells |
Bioorg Med Chem 15: 791-9 (2006)
Article DOI: 10.1016/j.bmc.2006.10.047 BindingDB Entry DOI: 10.7270/Q2DR2V4T |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50198033
(CHEMBL227484 | [(R)-2-methyl-1-(4'-methyl-biphenyl...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(C)cc1)P(O)(O)=O Show InChI InChI=1S/C17H22NO5PS/c1-12(2)17(24(19,20)21)18-25(22,23)16-10-8-15(9-11-16)14-6-4-13(3)5-7-14/h4-12,17-18H,1-3H3,(H2,19,20,21)/t17-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Università "G. d'Annunzio"
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MMP2 expressed in mouse myeloma cells |
Bioorg Med Chem 15: 791-9 (2006)
Article DOI: 10.1016/j.bmc.2006.10.047 BindingDB Entry DOI: 10.7270/Q2DR2V4T |
More data for this Ligand-Target Pair | |
Neutrophil collagenase
(Homo sapiens (Human)) | BDBM50198037
(CHEMBL228187 | [(R)-1-(3'-fluoro-biphenyl-4-sulfon...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1cccc(F)c1)P(O)(O)=O Show InChI InChI=1S/C16H19FNO5PS/c1-11(2)16(24(19,20)21)18-25(22,23)15-8-6-12(7-9-15)13-4-3-5-14(17)10-13/h3-11,16,18H,1-2H3,(H2,19,20,21)/t16-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Università "G. d'Annunzio"
Curated by ChEMBL
| Assay Description Inhibition of MMP8 |
Bioorg Med Chem 15: 791-9 (2006)
Article DOI: 10.1016/j.bmc.2006.10.047 BindingDB Entry DOI: 10.7270/Q2DR2V4T |
More data for this Ligand-Target Pair | 3D Structure (docked) |
Collagenase 3
(Homo sapiens (Human)) | BDBM12072
((R)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...)Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)P(O)(O)=O |r| Show InChI InChI=1S/C17H22NO6PS/c1-12(2)17(25(19,20)21)18-26(22,23)16-10-6-14(7-11-16)13-4-8-15(24-3)9-5-13/h4-12,17-18H,1-3H3,(H2,19,20,21)/t17-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Università "G. d'Annunzio"
Curated by ChEMBL
| Assay Description Inhibition of MMP13 |
Bioorg Med Chem 15: 791-9 (2006)
Article DOI: 10.1016/j.bmc.2006.10.047 BindingDB Entry DOI: 10.7270/Q2DR2V4T |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Homo sapiens (Human)) | BDBM50593778
(CHEMBL5189408)Show SMILES [O-][N+](=O)c1ccc(F)cc1OCC(=O)NCCN1CCN(Cc2ccccc2)CC1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114358 BindingDB Entry DOI: 10.7270/Q2JS9VF3 |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM12076
((2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-N-h...)Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1)C(=O)NO |r| Show InChI InChI=1S/C17H19BrN2O4S/c1-11(2)16(17(21)19-22)20-25(23,24)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,20,22H,1-2H3,(H,19,21)/t16-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Istituto di Cristallografia
| Assay Description Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ... |
J Med Chem 49: 923-31 (2006)
Article DOI: 10.1021/jm050787+ BindingDB Entry DOI: 10.7270/Q2348HM7 |
More data for this Ligand-Target Pair | |
Collagenase 3
(Homo sapiens (Human)) | BDBM50198033
(CHEMBL227484 | [(R)-2-methyl-1-(4'-methyl-biphenyl...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(C)cc1)P(O)(O)=O Show InChI InChI=1S/C17H22NO5PS/c1-12(2)17(24(19,20)21)18-25(22,23)16-10-8-15(9-11-16)14-6-4-13(3)5-7-14/h4-12,17-18H,1-3H3,(H2,19,20,21)/t17-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Università "G. d'Annunzio"
Curated by ChEMBL
| Assay Description Inhibition of MMP13 |
Bioorg Med Chem 15: 791-9 (2006)
Article DOI: 10.1016/j.bmc.2006.10.047 BindingDB Entry DOI: 10.7270/Q2DR2V4T |
More data for this Ligand-Target Pair | |
Collagenase 3
(Homo sapiens (Human)) | BDBM50198033
(CHEMBL227484 | [(R)-2-methyl-1-(4'-methyl-biphenyl...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(C)cc1)P(O)(O)=O Show InChI InChI=1S/C17H22NO5PS/c1-12(2)17(24(19,20)21)18-25(22,23)16-10-8-15(9-11-16)14-6-4-13(3)5-7-14/h4-12,17-18H,1-3H3,(H2,19,20,21)/t17-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Università "G. d'Annunzio"
Curated by ChEMBL
| Assay Description Inhibition of MMP13 |
Bioorg Med Chem 15: 791-9 (2006)
Article DOI: 10.1016/j.bmc.2006.10.047 BindingDB Entry DOI: 10.7270/Q2DR2V4T |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM12075
((2S)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1)C(O)=O |r| Show InChI InChI=1S/C17H18BrNO4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,1-2H3,(H,20,21)/t16-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Istituto di Cristallografia
| Assay Description Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ... |
J Med Chem 49: 923-31 (2006)
Article DOI: 10.1021/jm050787+ BindingDB Entry DOI: 10.7270/Q2348HM7 |
More data for this Ligand-Target Pair | |
Stromelysin-1
(Homo sapiens (Human)) | BDBM8485
((2R)-N-hydroxy-3-methyl-2-[(4-phenoxybenzene)sulfo...)Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO |r| Show InChI InChI=1S/C17H20N2O5S/c1-12(2)16(17(20)18-21)19-25(22,23)15-10-8-14(9-11-15)24-13-6-4-3-5-7-13/h3-12,16,19,21H,1-2H3,(H,18,20)/t16-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | 6.0 | 25 |
Istituto di Cristallografia
| Assay Description Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ... |
J Med Chem 49: 923-31 (2006)
Article DOI: 10.1021/jm050787+ BindingDB Entry DOI: 10.7270/Q2348HM7 |
More data for this Ligand-Target Pair | |
Matrix metalloproteinase-9
(Homo sapiens (Human)) | BDBM50198033
(CHEMBL227484 | [(R)-2-methyl-1-(4'-methyl-biphenyl...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(C)cc1)P(O)(O)=O Show InChI InChI=1S/C17H22NO5PS/c1-12(2)17(24(19,20)21)18-25(22,23)16-10-8-15(9-11-16)14-6-4-13(3)5-7-14/h4-12,17-18H,1-3H3,(H2,19,20,21)/t17-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Università "G. d'Annunzio"
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MMP9 expressed in mouse myeloma cells |
Bioorg Med Chem 15: 791-9 (2006)
Article DOI: 10.1016/j.bmc.2006.10.047 BindingDB Entry DOI: 10.7270/Q2DR2V4T |
More data for this Ligand-Target Pair | |
Collagenase 3
(Homo sapiens (Human)) | BDBM50198031
(CHEMBL227598 | [(R)-1-(4'-isopropoxy-biphenyl-4-su...)Show SMILES CC(C)Oc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](C(C)C)P(O)(O)=O Show InChI InChI=1S/C19H26NO6PS/c1-13(2)19(27(21,22)23)20-28(24,25)18-11-7-16(8-12-18)15-5-9-17(10-6-15)26-14(3)4/h5-14,19-20H,1-4H3,(H2,21,22,23)/t19-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Università "G. d'Annunzio"
Curated by ChEMBL
| Assay Description Inhibition of MMP13 |
Bioorg Med Chem 15: 791-9 (2006)
Article DOI: 10.1016/j.bmc.2006.10.047 BindingDB Entry DOI: 10.7270/Q2DR2V4T |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM26739
(3-(3-carbamoylphenyl)phenyl N-cyclohexylcarbamate ...)Show InChI InChI=1S/C20H22N2O3/c21-19(23)16-8-4-6-14(12-16)15-7-5-11-18(13-15)25-20(24)22-17-9-2-1-3-10-17/h4-8,11-13,17H,1-3,9-10H2,(H2,21,23)(H,22,24) | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari "Aldo Moro"
Curated by ChEMBL
| Assay Description Inhibition of FAAH in Wistar rat brain membranes assessed as reduction in [3H]anandamide hydrolysis using [3H]anandamide as substrate preincubated fo... |
J Med Chem 62: 10995-11003 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00885 BindingDB Entry DOI: 10.7270/Q26113K2 |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM12074
((2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1)C(O)=O |r| Show InChI InChI=1S/C17H18BrNO4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,1-2H3,(H,20,21)/t16-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Istituto di Cristallografia
| Assay Description Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ... |
J Med Chem 49: 923-31 (2006)
Article DOI: 10.1021/jm050787+ BindingDB Entry DOI: 10.7270/Q2348HM7 |
More data for this Ligand-Target Pair | |
Stromelysin-1
(Homo sapiens (Human)) | BDBM50198040
(CHEMBL389898 | [(R)-2-methyl-1-(4'-pyrrolidin-1-yl...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)N1CCCC1)P(O)(O)=O Show InChI InChI=1S/C20H27N2O5PS/c1-15(2)20(28(23,24)25)21-29(26,27)19-11-7-17(8-12-19)16-5-9-18(10-6-16)22-13-3-4-14-22/h5-12,15,20-21H,3-4,13-14H2,1-2H3,(H2,23,24,25)/t20-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Università "G. d'Annunzio"
Curated by ChEMBL
| Assay Description Inhibition of MMP3 |
Bioorg Med Chem 15: 791-9 (2006)
Article DOI: 10.1016/j.bmc.2006.10.047 BindingDB Entry DOI: 10.7270/Q2DR2V4T |
More data for this Ligand-Target Pair | |
Collagenase 3
(Homo sapiens (Human)) | BDBM50198034
(CHEMBL376557 | [(R)-1-(4'-chloro-biphenyl-4-sulfon...)Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(Cl)cc1)P(O)(O)=O Show InChI InChI=1S/C16H19ClNO5PS/c1-11(2)16(24(19,20)21)18-25(22,23)15-9-5-13(6-10-15)12-3-7-14(17)8-4-12/h3-11,16,18H,1-2H3,(H2,19,20,21)/t16-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Università "G. d'Annunzio"
Curated by ChEMBL
| Assay Description Inhibition of MMP13 |
Bioorg Med Chem 15: 791-9 (2006)
Article DOI: 10.1016/j.bmc.2006.10.047 BindingDB Entry DOI: 10.7270/Q2DR2V4T |
More data for this Ligand-Target Pair | |